DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28B and serpina1

DIOPT Version :9

Sequence 1:	NP_001260209.1	Gene:	Spn28B / 34035	FlyBaseID:	FBgn0083141	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	XP_017207927.1	Gene:	serpina1 / 322701	ZFINID:	ZDB-GENE-030131-1421	Length:	433	Species:	Danio rerio

Alignment Length:	387	Identity:	108/387 - (27%)
Similarity:	193/387 - (49%)	Gaps:	37/387 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLATSVESGFWEDFYRILAS--QNAKRNLIYSPISAEIIMSMVYMASGGKTFEELRNVLKFSE- 68
            ||...:.:..|  ..|:.|||  ....:|:.:||:...:.:|::.:.:...|..::.:.|.:|.
Zfish    65 LLAPHNADFAF--SLYKKLASNPDGQGKNIFFSPVGISMALSLLAVGAKASTLSQIYSGLGYSAL 127

  Fly    69 NKTLVANNYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFKAKAKSIRLDDPVS 133
            ....|...|..||..|...:..:.|.....:.:...:.:|.:|.:.|:..:.::|..:....|..
Zfish   128 TPEQVNEGYEHLLHMLGHSQDAMQLEAGAGVAIRDGFKVVDQFLKDAQHYYNSEAFGVDFSKPEI 192

  Fly   134 ASAIVNSWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKADQTHIADFYVSANEI 198
            |:|.:|.:|..:|...|.|:|  ||.::||...|:|.:||:|:|...|.|..||.|||.|..:..
Zfish   193 AAAEINKFIARKTHDKITNMV--KDLDADTVMMLINYMYFRGKWEKPFDAKLTHKADFKVDQDTT 255

  Fly   199 IPVKMMTLSASLLSGYIDDID-AKIIELPYWNSTLSMRIILPNSVDG-LRKLKEKVGFIDYHLE- 260
            :.|.||..:.. ...|.|.:: ..::.:||..:| ||.|:||:  || :::|:|.:  ..:||:
Zfish   256 VQVDMMKRTGR-YDIYQDPVNQTTVMMVPYKGNT-SMMIVLPD--DGKMKELEESI--CRHHLKN 314

  Fly   261 ------KKSVNVKLPKFKIESKAQLKGIFENLGILDVFKPSADLNGLVLESGAKIDKIVQKAFLK 319
                  :.||::.:|||.|.:.::|.||.:::|:.|.|...||.:|:..|...|:.:::.:|.:.
Zfish   315 WHDKLFRSSVDLFMPKFSISATSKLDGILKDMGMTDAFNDKADFSGMTEEVKVKVSQVLHQAVMS 379

  Fly   320 IDEKGGEASAATGVLTRRKKSIDNLIQP---PMEFIADHPFFYVIHDNKV--IYFQGHIVEP 376
            :||||.||:|.|.:          .|.|   |...|.:.||..:|.::..  |.|.|.|..|
Zfish   380 VDEKGTEAAAITTI----------EIMPMSLPDTVILNRPFLVLIVEDSTMSILFMGKITNP 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	104/372 (28%)
serpina1	XP_017207927.1	alpha-1-antitrypsin_like	69..428	CDD:239011	104/378 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010