DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28B and Serpinb3

DIOPT Version :9

Sequence 1:	NP_001260209.1	Gene:	Spn28B / 34035	FlyBaseID:	FBgn0083141	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001382662.1	Gene:	Serpinb3 / 304688	RGDID:	1549766	Length:	387	Species:	Rattus norvegicus

Alignment Length:	399	Identity:	121/399 - (30%)
Similarity:	207/399 - (51%)	Gaps:	38/399 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LYLLLLATSVESGFWEDFYRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEELRNVLKFSE 68
            ::|...||   :.|..:.||.|  ::::.|:.|||:|....::|:.:.:.|.|.:::...|:.||
  Rat     1 MHLFAKAT---TQFTLELYRQL--RDSEDNIFYSPLSIMTALAMLQLGAKGNTEKQIEKALQLSE 60

  Fly    69 -------------NKTLVANNYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFK 120
                         ::..|...:|.:::.|.:......|...|.||..|.:..:..|.:..:|.::
  Rat    61 TTKKPKEKSADSHDEENVHEQFRKIMNQLNKSNGAYDLKSPNSIYGAKGFPFLQTFMEDIKKYYQ 125

  Fly   121 AKAKSIRLDDPVSAS-AIVNSWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKAD 184
            |..:|:........| ..:|||:.|:|.|.|:::......||.|...||||:||||||.:.|...
  Rat   126 ANVESLDFAHAAEESQKKINSWVENKTNGKIKDLFPRGSLNSSTILVLVNAVYFKGQWNHKFDEQ 190

  Fly   185 QTHIADFYVSANEIIPVKMMTLSASLLSGYIDDIDAKIIELPYWNSTLSMRIILPNSVDGLRKLK 249
            :|....|:::.|...||:||..:......:::|:.||::|:||....|||.|:||..:|||:||:
  Rat   191 RTREDKFWLNKNTSKPVQMMRQTNEFNFIFLEDVQAKMVEIPYKGKELSMFILLPMEIDGLKKLE 255

  Fly   250 EKVG-------FIDYHLEKKSVNVKLPKFKIESKAQLKGIFENLGILDVFKP-SADLNGLVLESG 306
            ||:.       ....::....:|:.||:||::.|..|.|..|::|::|.|.| .||.:|:....|
  Rat   256 EKLSADTLLAWTSPKNMRMTQLNLSLPRFKVQEKYDLPGPLEHMGMVDAFNPQKADFSGMSSTKG 320

  Fly   307 AKIDKIVQKAFLKIDEKGGEASAATGVLTRRKKSIDNLIQPP--MEFIADHPFFYVIHDNKV--I 367
            ..:.|::.|:||:::|:|.||:|||||.||       ::..|  .||..:.||...|..|..  |
  Rat   321 LVVSKVLHKSFLEVNEEGAEAAAATGVETR-------ILSAPRTTEFTCNRPFIVFIKPNNTNSI 378

  Fly   368 YFQGHIVEP 376
            .|.|.:..|
  Rat   379 LFFGRVSSP 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	117/381 (31%)
Serpinb3	NP_001382662.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.830