DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28B and Serping1

DIOPT Version :9

Sequence 1:	NP_001260209.1	Gene:	Spn28B / 34035	FlyBaseID:	FBgn0083141	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_954524.1	Gene:	Serping1 / 295703	RGDID:	735225	Length:	504	Species:	Rattus norvegicus

Alignment Length:	384	Identity:	89/384 - (23%)
Similarity:	168/384 - (43%)	Gaps:	66/384 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FYRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEELRNVLKFSE-----NKTLVANNYRSL 80
            ::...|::.|:.|:.:||.|...:::.|.:.:|..|...|.::|.:.:     ::||.|.:.:.:
  Rat   159 YHAFSATKKAETNMAFSPFSIASLLTQVLLGAGDSTKSNLEDILSYPKDFACVHQTLKAFSSKGV 223

  Fly    81 LS--------DLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFKAKAKSIRLDDPVSASAI 137
            .|        ||..|:|::...::  :|.:....|.|:.:        |..|            :
  Rat   224 TSVSQIFHSPDLAIRDTYVNASLS--LYGSSPRVLGPDGD--------ANLK------------L 266

  Fly   138 VNSWILNRTRGMIRNIV--LPKDFNSDTSAFLVNAIYFKGQWLYNFKADQTHIADFYVSANEIIP 200
            :|:|:...|...|..::  ||    |||...|:||:|...:|...|  :|..:...::..|.:|.
  Rat   267 INTWVAENTNHKINELLDSLP----SDTRLVLLNAVYLSAKWKKTF--EQKKMMASFLYKNSMIK 325

  Fly   201 VKMMTLSASLLSGYIDD-IDAKIIELPYWNSTLSMRIILPNS----VDGLRKLKEKVGF--IDYH 258
            |.|::.....|:.:.|. :.||:.:|.. :..||..|::|.|    ::.:.|......|  |...
  Rat   326 VPMLSSKKYPLALFNDQTLKAKVGQLQL-SHNLSFVIMVPQSPTHQLEDMEKALNPTVFKAILKK 389

  Fly   259 LEKKSVN---VKLPKFKIESKAQLKGIFENLGILDVFKPSADLNGLVLESGAKIDKIVQKAFLKI 320
            ||.....   |.:|:.|::|...:..|.|.|...| |....:|.||..:...::..:..:..|::
  Rat   390 LELSKFQPTYVMMPRIKVKSSQDMLSIMEKLEFFD-FTYDLNLCGLTEDPDLQVSSMKHETVLEL 453

  Fly   321 DEKGGEASAATGVLTRRKKSIDNLIQPPMEFIADHPFFYVIHD--NKVIYFQGHIVEPR 377
            .|.|.||:||:.:...|...|         |....||.:::.|  :|...|.|.:.:||
  Rat   454 TETGVEAAAASTISVARNLLI---------FEVQQPFLFLLWDQRHKFPVFMGRVYDPR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	87/378 (23%)
Serping1	NP_954524.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..75
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..132
		SERPIN	150..499	CDD:294093	87/378 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100