DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28B and Serpinb1a

DIOPT Version :9

Sequence 1:	NP_001260209.1	Gene:	Spn28B / 34035	FlyBaseID:	FBgn0083141	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001026812.1	Gene:	Serpinb1a / 291091	RGDID:	1306203	Length:	379	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	126/385 - (32%)
Similarity:	194/385 - (50%)	Gaps:	29/385 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TSVESGFWEDFYRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEELRNVLKFSENKTLVAN 75
            :|..|.|..:.:..|:..:...|:.:||.|....::||::.:.|.|..:|.....|...:. |.:
  Rat     5 SSANSLFALELFHTLSESSPTGNIFFSPFSISSALAMVFLGTKGTTAAQLSKTFHFDSVED-VHS 68

  Fly    76 NYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFKAKAKSIRLDD-PVSASAIVN 139
            .::||.:::.:|.....|.:|||:|..|.|..:|||....:|.:.|....:.... ...|...:|
  Rat    69 RFQSLNAEVSKRGASHTLKLANRLYGEKTYNFLPEFLTSTQKMYGADLAPVDFQHASEDARKEIN 133

  Fly   140 SWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKADQTHIADFYVSANEIIPVKMM 204
            .|:..:|.|.|..::.....:|.|...|||||||||.|...|....|..|.|.::......||||
  Rat   134 QWVKGQTEGKIPELLAVGVVDSMTKLVLVNAIYFKGMWEEKFMKQDTTDAPFRLNKKNTKSVKMM 198

  Fly   205 TLSASLLSGYIDDIDAKIIELPYWNSTLSMRIILPNSVD----GLRKLKEKVGFIDY-------H 258
            ........|||.|:..|::|:||....|||.|:||..::    ||:|::|::.....       :
  Rat   199 YQKKKFFFGYISDLKCKVLEMPYQGGELSMVILLPEDIEDESTGLKKIEEQITLEKLREWTKREN 263

  Fly   259 LEKKSVNVKLPKFKIESKAQLKGIFENLGILDVFKPS-ADLNGLVLESGAK---IDKIVQKAFLK 319
            ||...|:||||:||||....|......||:.|:|..| |||:|:   ||::   |.|||.|||::
  Rat   264 LENIDVHVKLPRFKIEESYILNSNLGRLGLQDLFNSSKADLSGM---SGSRDLFISKIVHKAFVE 325

  Fly   320 IDEKGGEASAAT-GVLTRRKKSIDNLIQPPMEFIADHPFFYVIHDNKV--IYFQGHIVEP 376
            ::|:|.||:||| |:.|      ..::.|..||.|||||.:.|..|..  :.|.|.:..|
  Rat   326 VNEEGTEAAAATAGIAT------FCMLLPEEEFTADHPFIFFIRHNPTANVLFLGRVCSP 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	123/374 (33%)
Serpinb1a	NP_001026812.1	SERPIN	4..379	CDD:294093	125/383 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.930