DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spn28B and SERPINB1

DIOPT Version :9

Sequence 1:NP_001260209.1 Gene:Spn28B / 34035 FlyBaseID:FBgn0083141 Length:378 Species:Drosophila melanogaster
Sequence 2:NP_109591.1 Gene:SERPINB1 / 1992 HGNCID:3311 Length:379 Species:Homo sapiens


Alignment Length:385 Identity:129/385 - (33%)
Similarity:197/385 - (51%) Gaps:29/385 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 TSVESGFWEDFYRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEELRNVLKFSENKTLVAN 75
            :|..:.|..|.:..|:..|...|:..||.|....|:||::.:.|.|..:|.....|:..:. |.:
Human     5 SSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTVEE-VHS 68

  Fly    76 NYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFKAKAKSIRLDD-PVSASAIVN 139
            .::||.:|:.:|....||.:|||:|..|.|..:|||....:|.:.|...|:.... ...|...:|
Human    69 RFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTIN 133

  Fly   140 SWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKADQTHIADFYVSANEIIPVKMM 204
            .|:..:|.|.|..::.....::.|...|||||||||.|...|..:.|..|.|.::..:...||||
Human   134 QWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMM 198

  Fly   205 TLSASLLSGYIDDIDAKIIELPYWNSTLSMRIILPNSVD----GLRKLKEKVGFIDYH------- 258
            ........|||:|:..:::||||....|||.|:||:.::    ||:|::|::.....|       
Human   199 YQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPEN 263

  Fly   259 LEKKSVNVKLPKFKIESKAQLKGIFENLGILDVFKPS-ADLNGLVLESGAK---IDKIVQKAFLK 319
            |:...|||.||:||:|....|......||:.|:|..| |||:|:   |||:   |.|||.|:|::
Human   264 LDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGM---SGARDIFISKIVHKSFVE 325

  Fly   320 IDEKGGEASAAT-GVLTRRKKSIDNLIQPPMEFIADHPFFYVIHDNK--VIYFQGHIVEP 376
            ::|:|.||:||| |:.|      ..::.|...|.|||||.:.|..|.  .|.|.|....|
Human   326 VNEEGTEAAAATAGIAT------FCMLMPEENFTADHPFLFFIRHNSSGSILFLGRFSSP 379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spn28BNP_001260209.1 SERPIN 17..373 CDD:238101 127/374 (34%)
SERPINB1NP_109591.1 SERPIN 4..379 CDD:294093 128/383 (33%)
CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621 351..379 11/27 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57242
OrthoDB 1 1.010 - - D556621at33208
OrthoFinder 1 1.000 - - FOG0000050
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100128
Panther 1 1.100 - - O PTHR11461
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X28
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.930

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