DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28B and Serpind1

DIOPT Version :9

Sequence 1:	NP_001260209.1	Gene:	Spn28B / 34035	FlyBaseID:	FBgn0083141	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001317976.1	Gene:	Serpind1 / 15160	MGIID:	96051	Length:	478	Species:	Mus musculus

Alignment Length:	375	Identity:	96/375 - (25%)
Similarity:	184/375 - (49%)	Gaps:	32/375 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DFYRILASQ-NAKRNLIYSPISAEIIMSMVYMASGGKTFEELRNVLKFSE--------NKTLVAN 75
            :.||:|..| ....||..:|:.....|.|:.:...|:|.||:.:||.|.:        ..|.:.|
Mouse   115 NLYRVLKDQATTSDNLFIAPVGISTAMGMISLGLRGETHEEVHSVLHFRDFVNASSKYEVTTIHN 179

  Fly    76 NYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFKAKAKSIRLDDPVSASAIVNS 140
            .:|.|...|.||.....|...|.:|:.|::.:..:|....|:.:.|:|:.....||...|. .|:
Mouse   180 LFRKLTHRLFRRNFGYTLRSVNGLYIQKQFPIREDFKAAMREFYFAEAQEANFPDPAFISK-ANN 243

  Fly   141 WILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKADQTHIADFYVSANEIIPVKMMT 205
            .||..|:|:|:..:  ::.:..|...::|.|||||.|:..|..:.||..:|.::..|::.|.||.
Mouse   244 HILKLTKGLIKEAL--ENIDPATQMLILNCIYFKGTWVNKFPVEMTHNHNFRLNEREVVKVSMMQ 306

  Fly   206 LSASLLSGYIDDIDAKIIELPYWNSTLSMRIILPNSVDGLRKLKEKV-GFIDYHLEKKSVN---- 265
            ...:.|:....::|..|::|.|... :||.|::|..:.|::.|:.:: ..:....:|...|
Mouse   307 TKGNFLAANDQELDCDILQLEYVGG-ISMLIVVPRKLSGMKTLEAQLTPQVVERWQKSMTNRTRE 370

  Fly   266 VKLPKFKIESKAQLKGIFENLGILDVFKPSADLNGLVLESGAKIDKIVQKAFLKIDEKGGEASAA 330
            |.|||||:|....|..:.:::||..:|..:.:::| :.:....||....::.:.::|:|.:|:|.
Mouse   371 VLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSG-ISDQRIAIDLFKHQSTITVNEEGTQAAAV 434

  Fly   331 T--GVLTRRKKSIDNLIQPPMEFIADHPFFYVIHDNKV--IYFQGHIVEP 376
            |  |.:.         :...:.|..|.||.:::::::.  :.|.|.:..|
Mouse   435 TTVGFMP---------LSTQVRFTVDRPFLFLVYEHRTSCLLFMGKVTNP 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	95/370 (26%)
Serpind1	NP_001317976.1	HCII	43..476	CDD:239002	96/375 (26%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	54..78
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	171..191		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020