DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28B and SERPINA12

DIOPT Version :9

Sequence 1:	NP_001260209.1	Gene:	Spn28B / 34035	FlyBaseID:	FBgn0083141	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001291390.1	Gene:	SERPINA12 / 145264	HGNCID:	18359	Length:	414	Species:	Homo sapiens

Alignment Length:	380	Identity:	95/380 - (25%)
Similarity:	176/380 - (46%)	Gaps:	27/380 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLATSVESGFWEDFYRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEELR---NVLKFSEN 69
            |...:::.||  ...:.||..|..||:..||:|.....||:.:.:...|.:|::   |..|..|.
Human    48 LARQNMDLGF--KLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFRKMPEK 110

  Fly    70 KTLVANNYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFKAKAKSIRLDDPVSA 134
            .  :...:..::.:|.::...:.|.:.|.::::::.....:|.:.|:..:.|:.......:...|
Human   111 D--LHEGFHYIIHELTQKTQDLKLSIGNTLFIDQRLQPQRKFLEDAKNFYSAETILTNFQNLEMA 173

  Fly   135 SAIVNSWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKADQTHIADFYVSANEII 199
            ...:|.:|..:|.|.|.|::  ::.:..|...|.|.|:|:.:|.:.|..:.|...||::..|..:
Human   174 QKQINDFISQKTHGKINNLI--ENIDPGTVMLLANYIFFRARWKHEFDPNVTKEEDFFLEKNSSV 236

  Fly   200 PVKMMTLSASLLSGYIDDIDAKIIELPYWNSTLSMRIILPNSVDGLRKLKEKVGFIDYH------ 258
            .|.||..|.....||.|.:...|:|:|| ...::...|||:  :|..|..||...:|..
Human   237 KVPMMFRSGIYQVGYDDKLSCTILEIPY-QKNITAIFILPD--EGKLKHLEKGLQVDTFSRWKTL 298

  Fly   259 LEKKSVNVKLPKFKIESKAQLKGIFENLGILDVFKPSADLNGLVLESGAKIDKIVQKAFLKIDEK 323
            |.::.|:|.:|:..:.....||.....:|:..:|:...||..:......|:.:.|.||.||:||:
Human   299 LSRRVVDVSVPRLHMTGTFDLKKTLSYIGVSKIFEEHGDLTKIAPHRSLKVGEAVHKAELKMDER 363

  Fly   324 GGEASAATGVLTRRKKSIDNLIQPPMEFIADHPFFYVIHDNKV--IYFQGHIVEP 376
            |.|.:|.||..|..       ::.|:....|.|:..:|:..|:  :.|.|.||.|
Human   364 GTEGAAGTGAQTLP-------METPLVVKIDKPYLLLIYSEKIPSVLFLGKIVNP 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	90/366 (25%)
SERPINA12	NP_001291390.1	serpinA12_vaspin	40..411	CDD:381026	94/378 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010