DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28B and Serpinh1

DIOPT Version :9

Sequence 1:	NP_001260209.1	Gene:	Spn28B / 34035	FlyBaseID:	FBgn0083141	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001104513.1	Gene:	Serpinh1 / 12406	MGIID:	88283	Length:	417	Species:	Mus musculus

Alignment Length:	381	Identity:	93/381 - (24%)
Similarity:	165/381 - (43%)	Gaps:	36/381 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SGFWEDFYRILASQNAKRNLIYSPISAEIIMSMVYMASGGKTFEELRNV-----LKFSENKTLVA 74
            :|.....|:.:|...|..|::.||:.....:.:|.:.....|..:.:.|     |:..|..|.:.
Mouse    47 TGLAFSLYQAMAKDQAVENILLSPLVVASSLGLVSLGGKATTASQAKAVLSAEKLRDEEVHTGLG 111

  Fly    75 NNYRSLLSDLKRRETFIILHMANRIYVNKKYCLVPEFNQLARKAFKAKAKSIRLDDPVSASAIVN 139
            ...|||.:...|..|:   .:.:|:|.........:|.:.:::.:..:...|...|..||...:|
Mouse   112 ELLRSLSNSTARNVTW---KLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSIN 173

  Fly   140 SWILNRTRGMIRNIVLPKDFNSDTSAFLVNAIYFKGQWLYNFKADQTHIADFYVSANEIIPVKMM 204
            .|....|.|.:..:.  ||......|.||||::||..|...|.........|.|:.:..:.|.||
Mouse   174 EWASQTTDGKLPEVT--KDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMM 236

  Fly   205 TLSASLLSGYIDDIDAKI--IELPYWNSTLSMRIILPNSVDGLRKL-----KEKVGFIDYHLEKK 262
            ..:.  |..|.||...|:  :|:|..:...|:.|::|:.|:.|.:|     ||::......::||
Mouse   237 HRTG--LYNYYDDEKEKLQMVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKAWMGKMQKK 299

  Fly   263 SVNVKLPKFKIESKAQLKGIFENLGILD-VFKPSADLNGLVLESGAK---IDKIVQKAFLKIDEK 323
            :|.:.|||..:|....|:.....||:.: :.|..|||:.:   ||.|   :..:......:.|.:
Mouse   300 AVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRM---SGKKDLYLASVFHATAFEWDTE 361

  Fly   324 GGEASAATGVLTRRKKSIDNLIQPPMEFIADHPFFYVIHDNK--VIYFQGHIVEPR 377
            |....  ..:..|.:      ::.|..|.|||||.:::.||:  .:.|.|.:|.|:
Mouse   362 GNPFD--QDIYGREE------LRSPKLFYADHPFIFLVRDNQSGSLLFIGRLVRPK 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28B	NP_001260209.1	SERPIN	17..373	CDD:238101	90/373 (24%)
Serpinh1	NP_001104513.1	serpinH1_CBP1	35..416	CDD:381003	93/381 (24%)
Serpinh1	NP_001104513.1	Prevents secretion from ER. /evidence=ECO:0000305	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010