DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RapGAP1 and GARNL3

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	XP_005252324.1	Gene:	GARNL3 / 84253	HGNCID:	25425	Length:	1076	Species:	Homo sapiens

Alignment Length:	464	Identity:	158/464 - (34%)
Similarity:	233/464 - (50%)	Gaps:	69/464 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 PQLSGVVSAS-----GCQL--LSNGHHYQSQSSVSSNSSIVSAIPASQRLL-------EEALAKP 288
            |:|...|:.|     ||:.  .|..|:...:..:||::.  .||..:.|..       |.|.|.|
Human    80 PELESQVNLSVSEDLGCRRGDFSRKHYGSVELLISSDAD--GAIQRAGRFRVENGSSDENATALP 142

  Fly   289 APYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTTWMAKFETDDTAKCYRRFYAAREHSNLIG 353
                        |.|.....|      ..||.. .|.|            |.:::..:.|.|.||
Human   143 ------------GTWRRTDVH------LENPEY-HTRW------------YFKYFLGQVHQNYIG 176

  Fly   354 LDEQLGPILLSIKTENVANQ---EHMRILMRLRTGTMHELLPVSCLLPQPSPAKMAHTLNENITV 415
            .|.:..|..||:...:..||   ::..||.| :|||....||.|     |:......::...:.:
Human   177 NDAEKSPFFLSVTLSDQNNQRVPQYRAILWR-KTGTQKICLPYS-----PTKTLSVKSILSAMNL 235

  Fly   416 EHF----MPILCPKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVL 476
            :.|    ..|..|:..:.:.|.:|.....:||||||:.:.||.|::|:|.|:..|..|.:||::|
Human   236 DKFEKGPREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLL 300

  Fly   477 GQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDI 541
            |..|.||...|||||||.:|..||..:||.|::..||||||||:||:::.:.||::|||||||||
Human   301 GDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDI 365

  Fly   542 VAIVFQ---ETNTPFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPAV 603
            |.||||   |::..|.|.||.|||.|.|.:|:   .|..:..|::.:.:.:.||.|||.||.|.|
Human   366 VTIVFQEGEESSPAFKPSMIRSHFTHIFALVR---YNQQNDNYRLKIFSEESVPLFGPPLPTPPV 427

  Fly   604 FRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSAG 668
            |...|||::|:|.||||.|.|..:...||:..:||...|:::|.::|..   |.....|::.|..
Human   428 FTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMP---DLHKNMLNRRSFS 489

  Fly   669 SPTPETPKA 677
            ...||:||:
Human   490 DVLPESPKS 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	87/181 (48%)
GARNL3	XP_005252324.1	Rap_GAP	284..462	CDD:280332	86/180 (48%)
GARNL3	XP_005252324.1	CNH	556..860	CDD:279162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151810
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845465at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750