Protein Alignment RapGAP1 and TSC2

DIOPT Version :9

• Sequence 1: NP_001097114.2
• Gene: RapGAP1 / 34032
• FlyBaseID: FBgn0264895
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: XP_011520940.2
• Gene: TSC2 / 7249
• HGNCID: 12363
• Length: 1879
• Species: Homo sapiens
• Alignment Length: 802
• Identity: 177/802 - (22%)
• Similarity: 267/802 - (33%)
• Gaps: 228/802 - (28%)

  Fly    11 GHPIIVGSSEISLAPSS----AASSPKP-LHRMIKYWRNSSG-KIPGLRK----------SESFA 59
            ||.:.||:.::   |:|    :|:||.| .....|..:.|:| ::|...|          ::.:|
Human  1188 GHGLRVGALDV---PASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWA 1249

  Fly    60 E--YRRHSSNSATISGGSGGRSSTSSARQLQYQRLEMESCENIDMLTEPLRRQHAFMANTQKQQP 122
            |  .||.:.|::.:.......|..||    ....:.::...|..|..|..:.............|
Human  1250 EILVRRPTGNTSWLMSLENPLSPFSS----DINNMPLQELSNALMAAERFKEHRDTALYKSLSVP 1310

  Fly   123 AGGGSGSGSVTHSPERLRGATTATQDLFELLERVQCSRLDDQRCVLPAYFSQNHHRGSNA----- 182
            |      .|....|...|..|.|:   |..|.:..|.....:........||....|..|
Human  1311 A------ASTAKPPPLPRSNTVAS---FSSLYQSSCQGQLHRSVSWAGIASQREAVGCRAPLCLI 1366

  Fly   183 SEERVPQPHSPHDSHAHPHNGGLQHSGSRATL-RHSMNHSSSSTVSGSACSSTPASPQLSG---- 242
            ....|.:..||.:........||:...:...: |.:..:|.||:||.....|..|. :|.|
Human  1367 DSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAE-ELVGRGIP 1430

  Fly   243 ---VVSASGCQLLSNGHHYQSQSSVSSNSSIVSAIPASQRLLEEALAKPAP-------YPMILLP 297
               |||:.|.:...:.....||....|:||     |..| .|::.|..|..       .|.:...
Human  1431 IERVVSSEGGRPSVDLSFQPSQPLSKSSSS-----PELQ-TLQDILGDPGDKADVGRLSPEVKAR 1489

  Fly   298 LHGGYWMDGTE---HECGYDARGNP--LLPQTTWMAK-------FETDDTAKCYRRFYAARE--- 347
            ...| .:||..   ...|.|:||.|  .||.::..:.       :...|:|...|.....|:
Human  1490 SQSG-TLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALK 1553

  Fly   348 ------------------------HSNLIGLDEQLGPILLSIKTENVANQEHMRILMRLRTGTMH 388
                                    ||...| ||...||||.
Human  1554 SRATASNAEKVPGINPSFVFLQLYHSPFFG-DESNKPILLP------------------------ 1593

  Fly   389 ELLPVSCLLPQPSPAKMAHTLNENITVEHFMPILCPKASQLISVYDEHVLVSHFKFGVLYQRYGQ 453
                                 ||:.:.|..:.:|     ..|..||.|      |..|||...||
Human  1594 ---------------------NESQSFERSVQLL-----DQIPSYDTH------KIAVLYVGEGQ 1626

  Fly   454 TTEE-ELFGNQQTSPAFDEFLDVLGQRIRLKD---HKGYRGGLDIQNGHTGDTAVYEVFKEREIM 514
            :..| .:..|:..|..:.|||..||:.|.|||   .|.|.||||:    .|:...:......:||
Human  1627 SNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDV----CGEDGQFTYCWHDDIM 1687

  Fly   515 ---FHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQPIEPNT 576
               ||::||:|..:.|..:..:|||:|||.|:||:.::...|....|...|....::|.|::
Human  1688 QAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLD--- 1749

  Fly   577 PHTRYK---VSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKFA------ 632
                |:   ||:..|.|:                :...:..:.|:::..|..:.|.:.|
Human  1750 ----YECNLVSLQCRKDM----------------EGLVDTSVAKIVSDRNLPFVARQMALHANMA 1794

  Fly   633 ----------------KLEQRTR--TSLLQNLCEELREKTRDFLGTDLSQTSAGSPTPETPKAES 679
                            |...|.|  ..|.|.:|||........   .|....:.|..|....||.
Human  1795 SQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSL---PLVHPPSHSKAPAQTPAEP 1856

  Fly   680 GSGGNAGSRFIDTVKKALIMRV 701
            ..|...|.|      |.||..|
Human  1857 TPGYEVGQR------KRLISSV 1872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	3/20 (15%)
		Rap_GAP	460..639	CDD:280332	51/209 (24%)
TSC2	XP_011520940.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1559
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030