DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RapGAP1 and SIPA1

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_006738.3	Gene:	SIPA1 / 6494	HGNCID:	10885	Length:	1042	Species:	Homo sapiens

Alignment Length:	670	Identity:	206/670 - (30%)
Similarity:	279/670 - (41%)	Gaps:	205/670 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 GGSGSGSVTHSPERLRG-ATTATQDLFELLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVP 188
            ||.|      ||.  || |..:|.|||                               |.:.|.|
Human     6 GGVG------SPR--RGMAPASTDDLF-------------------------------ARKLRQP 31

  Fly   189 --QPHSPHDSHAHPHNGGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQL 251
              .|.:||.....|..|.|..|||.|               |.|...|||||:
Human    32 ARPPLTPHTFEPRPVRGPLLRSGSDA---------------GEARPPTPASPR------------ 69

  Fly   252 LSNGHHYQSQSSVSSNSSIVSAIPASQRLLEEALA-------KPAP-YPMILLP----------- 297
             :..|.::..|..::.|:         ||..:.||       :|.| :|.:|.|
Human    70 -ARAHSHEEASRPAATST---------RLFTDPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSL 124

  Fly   298 ----------------------------------LHG--GYWMD-GTEHECGYDARGNPLLP--- 322
                                              |||  |:..: |.|.|.|.....:|.:|
Human   125 LFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGPASPPVPPAL 189

  Fly   323 -------------QTTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVANQ- 373
                         :|:..:....|..|..||:::..:||.|..|:||.|||:.:|::.|.....
Human   190 PNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSG 254

  Fly   374 ----EHMRILMR---LRT--GTMHELLPVSCLLPQP----SPAKMAHTLNENITVEHFMPIL--- 422
                ...|:::|   |||  ||:.|    ..|.|.|    ||.|:         :||..|.|
Human   255 GGTLHSYRVIVRTTQLRTLRGTISE----DALPPGPPRGLSPRKL---------LEHVAPQLSPS 306

  Fly   423 C-------PKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRI 480
            |       ||..:.:...||.||....|.|:||.|.||.:|||::.||:..|||.:||.:||..:
Human   307 CLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVV 371

  Fly   481 RLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIV 545
            |||..:.||..||.:...||..::|..:::.||||||||:||:|..:.|||.||||||||||.||
Human   372 RLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIV 436

  Fly   546 FQETNT-PFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLP-NPAVFRKGQ 608
            |||..: ||.|..|.|||.|.|:||:...|.||||.|:|:|:...|.|.|||.|| ....|....
Human   437 FQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHTTYRVAVSRTQDTPAFGPALPAGGGPFAANA 501

  Fly   609 EFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSA-GSPT- 671
            :|:.|:|.|.:|.|.|...|.:|..:..|||...||:|.      |.:...|.|...|. |.|:
Human   502 DFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA------TNEVTTTSLDSASRFGLPSL 560

  Fly   672 -------PETPKAESGSGGN 684
                   |..|.||..:.|:
Human   561 GGRRRAAPRGPGAELQAAGS 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	3/20 (15%)
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	85/180 (47%)
SIPA1	NP_006738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..87		35/156 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..153		0/20 (0%)
		Rap_GAP	351..532	CDD:396632	85/180 (47%)
		PDZ	687..759	CDD:395476
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..903
		Smc	<905..>1027	CDD:224117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	946..980
		ZapB	974..1030	CDD:399182
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151809
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740