Protein Alignment RapGAP1 and RALGAPA2

DIOPT Version :10

• Sequence 1: NP_001097114.2
• Gene: RapGAP1 / 34032
• FlyBaseID: FBgn0264895
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: XP_006723661.1
• Gene: RALGAPA2 / 57186
• HGNCID: 16207
• Length: 1970
• Species: Homo sapiens
• Alignment Length: 717
• Identity: 149/717 - (20%)
• Similarity: 253/717 - (35%)
• Gaps: 204/717 - (28%)

  Fly   141 GATTATQDLFELLERVQCSRLD--------DQRCVLPAYFSQNHHRGS---------NASEERVP 188
            |::|.||....:|.....|..|        :.:...|..:..:...|:         ..|.|.:|
Human  1355 GSSTYTQQSHYILTLADLSSTDYDPFLPLANVKSSEPVQYHSSAELGNLLTVEEEKKRRSLELIP 1419

  Fly   189 QPHSPHDSHAHPHNGGLQHSGSRATLRHSM---NHSSSSTVSGSACS-STPASPQLSGVVSASGC 249
            .......:|...|.|....||..|.| ||:   ||.::. |.||..| ....||.|
Human  1420 LTARMVMAHLVNHLGHYPLSGGPAIL-HSLVSENHDNAH-VEGSELSFEVFRSPNL--------- 1473

  Fly   250 QLLSNGHHYQSQSSVSSNSSIVSAI--PASQRLLEEALAKPAPYPMILLPLHGGYWMDGTE---- 308
                       |..|.::|:::|.:  |....:....:...:...:|:..:.|.|..||..
Human  1474 -----------QLFVFNDSTLISYLQTPTEGPVGGSPVGSLSDVRVIVRDISGKYSWDGKVLYGP 1527

  Fly   309 -HECGYDARGNPLLPQTTWMAKFETDDTAKCYRRFYAAREHSNLIG-----LD---EQLG----- 359
             ..|......||....::|            :|..:..::.|:.:.     ||   |.:|
Human  1528 LEGCLAPNGRNPSFLISSW------------HRDTFGPQKDSSQVEEGDDVLDKLLENIGHTSPE 1580

  Fly   360 ---PILLSIKTENVA--------NQEHMRILMR--------LRTGTMHELLPVSCLLPQPSPA-- 403
               |..|::...::.        .:|.:.:::|        :::......:.|:. ..||||.
Human  1581 CLLPSQLNLNEPSLTPCGMNYDQEKEIIEVILRQNAQEDEYIQSHNFDSAMKVTS-QGQPSPVEP 1644

  Fly   404 ----------------------KMAHTLNENITVEHFMPILCPKASQLISVYDEHVLVSHFKFGV 446
                                  |..|.|.:|           .|..:.:...|........|..|
Human  1645 RGPFYFCRLLLDDLGMNSWDRRKNFHLLKKN-----------SKLLRELKNLDSRQCRETHKIAV 1698

  Fly   447 LYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKER 511
            .|...||..:..:..|::.|.|:::|:..||..:.|..|.|:.|||. :||.||.||.|......
Human  1699 FYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQ-RNGSTGQTAPYYATSTV 1762

  Fly   512 EIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQPIEPNT 576
            |::|||||.:| ::.|....::.||:|||.|.||:.|.:..:...:|.:.|....|::.|::
Human  1763 EVIFHVSTRMP-SDSDDSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMK--- 1823

  Fly   577 PHTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENA--C-------YKAEKFA 632
             :..:.:::|.:.:||||||......|  .|:.....:....|||..|  |       :..|:..
Human  1824 -NHMFFIAITKKPEVPFFGPLFDGAIV--SGKLLPSLVCATCINASRAVKCLIPLYQSFYEERAL 1885

  Fly   633 KLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSAGSPTPETPKAESGSGGNAGSRFIDTVKKAL 697
            .||     :::||..|.:  ...||      .....||:|.  .:.||:|..|.|...|..:
Human  1886 YLE-----AIIQNHREVM--TFEDF------AAQVFSPSPS--YSLSGTGALASSLSADLEE--- 1932

  Fly   698 IMRVRSQSVDTGNGHGPGQTDKFSVNTKLGTLNSKKETHPEMQTP---------NLNTCSRTASK 753
                                          .|:.::..||.:..|         ....|:...|:
Human  1933 ------------------------------PLSEEETEHPLLPLPRATKPRISRKFRCCTSALSR 1967

  Fly   754 SS 755
            ||
Human  1968 SS 1969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:460481	4/28 (14%)
		Rap_GAP	460..639	CDD:460463	57/187 (30%)
RALGAPA2	XP_006723661.1	RALGAPB_N	534..658	CDD:466561
		Rap_GAP	1712..1884	CDD:460463	55/179 (31%)