Protein Alignment RapGAP1 and Ralgapa1

DIOPT Version :10

• Sequence 1: NP_001097114.2
• Gene: RapGAP1 / 34032
• FlyBaseID: FBgn0264895
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: XP_030102685.1
• Gene: Ralgapa1 / 56784
• MGIID: 1931050
• Length: 2586
• Species: Mus musculus
• Alignment Length: 674
• Identity: 152/674 - (22%)
• Similarity: 249/674 - (36%)
• Gaps: 178/674 - (26%)

  Fly   169 PAYF--------SQNHHRGSNASEERVPQP-HSP---HDSHAHP-------HNGGLQHSGSRATL 214
            |.||        |.::....:....:.|:| |||   ..|...|       ...||....:|..:
Mouse  1948 PKYFPISLSDLASVDYDPFMHLESLKEPEPLHSPDSERSSKLQPVTEVKTQMQQGLISIAARTVI 2012

  Fly   215 RHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQLLSNGHHYQSQSSVS-------------- 265
            .|.:||.....:||.     ||      ::::..|:  ::.:||...:.:|
Mouse  2013 THLVNHLGHYPMSGG-----PA------MLTSQVCE--NHDNHYSESTELSPELFESPNIQFFVL 2064

  Fly   266 SNSSIVSAIPASQRLLEEAL----------AKPAPYPMILLPLHGGYWMDGTEHECGYDARGNPL 320
            :|:::||.|   |...||::          :..:...:|:..|.|.|..|..      ...|.|:
Mouse  2065 NNTTLVSCI---QIRSEESMPGGGLAAGLVSANSNVRIIVRDLSGKYSWDSA------ILYGPPI 2120

  Fly   321 ---LPQTTW-------MAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVANQEH 375
               ||:.|.       ..|.|...|:.......|.::     ||..||.....::.|.:...:|.
Mouse  2121 VSGLPEPTSFILSMSDQEKPEEPPTSNECLEDIAVKD-----GLSLQLRRFRETVPTWSTIREEE 2180

  Fly   376 ---MRILMRLRTGTMHELLP---VSCLLPQPSPAKMA--------------HTLNENITVEHFMP 420
               ..:|..|.| |..|.|.   :|..:|.|.|..::              :|..:....:||..
Mouse  2181 DVLDELLQYLGT-TSPECLQRTGISLNVPAPQPLCISEKQENDVINAILKQYTEEKEFVEKHFND 2244

  Fly   421 ILCPKASQ------------------LISV-----YDE----HVLVSH----------------- 441
             |..|||:                  |:|:     :|:    |:|..:
Mouse  2245 -LNMKASEQDEPTPQKPQSAFYYCRLLLSILGMNSWDKRRSFHLLKKNEKLLRELRNLDSRQCRE 2308

  Fly   442 -FKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVY 505
             .|..|.|...||..:..:..|...|.|:::|:..||..:.|.:|.|:.|||. :|..||.|..|
Mouse  2309 THKIAVFYVAEGQEDKYSILTNIGGSQAYEDFVAGLGWEVNLTNHCGFMGGLQ-KNRSTGLTTPY 2372

  Fly   506 EVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQ 570
            ......|::|||||.:| ::.|....::.||:|||.|.||:.|....:...:|.:.|....||:.
Mouse  2373 FATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIY 2436

  Fly   571 PIEPNTPHTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKA----EKF 631
            |::    :..:.:.:..:.:||||||......|  .|:.....:.:..|||..|....    :.|
Mouse  2437 PMK----NHMFSIQIMKKPEVPFFGPLFDGAIV--NGKVLPIMVRSTAINASRALKSLIPLYQNF 2495

  Fly   632 AKLEQRTRTSLLQNLCEELREKT--RDFLGTDLSQT--------SAGS-----PTPETPKAESGS 681
              .|:|.|  .||.:.:...|.|  .||.....|..        :.||     |:...|.|:...
Mouse  2496 --YEERAR--YLQTIVQHHLEPTTFEDFAAQVFSPAPYHHFPADAVGSYPEIPPSDAAPAAQVDG 2556

  Fly   682 GGNAGSRFIDTVKKALIMRVRSQS 705
            ...|......|.|..:.|::|..|
Mouse  2557 ADLASPMSPRTSKSRMSMKLRRSS 2580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:460481
		Rap_GAP	460..639	CDD:460463	54/182 (30%)
Ralgapa1	XP_030102685.1	RALGAPB_N	549..677	CDD:466561
		Rap_GAP	2328..2501	CDD:460463	54/182 (30%)