DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RapGAP1 and sipa1l1

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001268721.1	Gene:	sipa1l1 / 562521	ZFINID:	ZDB-GENE-030131-9909	Length:	1794	Species:	Danio rerio

Alignment Length:	943	Identity:	263/943 - (27%)
Similarity:	380/943 - (40%)	Gaps:	215/943 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GSSEISLAPSSAASSPKPLHRMIKYWRNSSGKIPGL----RKSESFA----EYRRHSSNSATISG 73
            |.....|:|.....||:...|.|:...||...|..|    .:..||:    .:|.:.|.|:....
Zfish   152 GKDNRFLSPDGYLGSPRKGMRRIRQRSNSDITISELDGDGSEGWSFSGWTPMHREYGSTSSIDKH 216

  Fly    74 GSGGRSSTSSARQLQYQRLEMESCENIDMLTEPLRRQHAFMANTQKQQPAGGGSGSGSV-----T 133
            |..|.|.....:.......:..| ...:.|:|.|...|...|......|.|...||.:.     .
Zfish   217 GVSGESFFDMLKGYTTDAPDQRS-PAPEKLSELLTVAHKQTALDLPDGPLGPPRGSPASRLKERE 280

  Fly   134 HSPERLRGATTATQDLFELLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEER------VPQPHS 192
            ...:|...:.|..:.:|..|..|:... |..|.            ||:|.:.:      .|:|..
Zfish   281 KQMKRRSKSETGGESIFRKLRSVKAEG-DSSRA------------GSDAEDGKSDDLGPPPKPWV 332

  Fly   193 PHDSHAH--------PHNGGLQH-----------SGSRATLRHSMNHSS--SSTVS---GSACSS 233
            .....||        ..|..:|.           :|:.|....|.:::|  |||.|   ||.|.|
Zfish   333 CQKGFAHFDVQSILFDLNEVVQSRQSAAKRKNTTTGASAAAAASASNTSSLSSTQSGAYGSPCGS 397

  Fly   234 TPASPQLSGVVSASG----------CQLLSN--GHHYQSQSSVSSNSSIVSAIPASQRLLEEALA 286
            ........|....||          |....|  |...:...|.|...||.|...:|.| .||...
Zfish   398 QEELSVKDGPSLDSGDDKSNDLVLSCPCFRNEIGGEGERNISPSKQGSIGSGASSSSR-DEEGSP 461

  Fly   287 KPAP--------YPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTTWMAKFETDDTAKCYRRFY 343
            :.||        ..::..|..|    ....|:.|   :.|.|         ...|..|..||:.:
Zfish   462 ERAPNTHFSNAGVAVLEAPKDG----KSLHHDRG---KSNIL---------EHVDLGAYYYRKNF 510

  Fly   344 AAREHSNLIGLDEQLGPILLSIKTENVA-NQEH-----MRILMRLRTGTMHELLPV-SCLLPQPS 401
            ..|||.|.:|:||.|||:.:||:.|.:. ::||     .||:.|     ..||..: ..:|....
Zfish   511 YLREHWNYLGVDETLGPVAVSIRREKLEDHKEHGQQYNYRIIFR-----TSELTTIRGSILEDAV 570

  Fly   402 PAKMAHTLNENI----TVEHFMPIL---C-------PKASQLISVYDEHVLVSHFKFGVLYQRYG 452
            |:...|.|...:    .:::.:|.|   |       ||.::.:...||..|....|.||:|.:.|
Zfish   571 PSTSKHGLARGLPLKEVLDYLVPELNAHCLRLALNTPKVTEQLMKLDEQGLSFQLKVGVMYCQAG 635

  Fly   453 QTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHV 517
            |::|||::.|:...||.:|||.:||:|:|||....||..||.:...||..::|..||:.||||||
Zfish   636 QSSEEEMYNNETAGPALEEFLQLLGERVRLKGFSKYRAQLDTKTDSTGTHSLYTTFKDYEIMFHV 700

  Fly   518 STLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNT-PFSPDMIASHFLHAFIVVQPIEPNTPHTRY 581
            ||:||:|..:.|||.||||||||||.|||||... ||||..|.|||.|.|:||:.:.|.|.:..|
Zfish   701 STMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAKPFSPKNIRSHFQHVFVVVRALNPCTENACY 765

  Fly   582 KVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNL 646
            :|:|....|||.|||.:|..|.|.|...|::|:|.|:||||||.:|::||..:..|||...|::|
Zfish   766 RVAVARSRDVPAFGPPIPEDATFPKSTVFRDFLLAKVINAENAAHKSDKFRAMATRTRQEYLRDL 830

  Fly   647 CE---------------------ELREKTRDFLGTDLSQTSAGSPTPETPKAESGSGG------- 683
            .|                     :.:||||.:||.:|  .|.|:.|......:.|:||
Zfish   831 AERHVTSTPIDPSGKFPFISLAHKRKEKTRPYLGAEL--RSPGAITWPVYAEDHGAGGELEALLA 893

  Fly   684 --NAGSRFIDTVKKALIMRVRSQSVDTGNGHGPGQTDKFSVNTKLGTLNSKKETHPEMQTPNLNT 746
              |.....:|...||::.....:.|               :...||:..|.|..:...:..:|
Zfish   894 ISNDFLVLVDPEAKAVVFNCAVRDV---------------IGWTLGSPASMKIYYERGENISL-- 941

  Fly   747 CSRTASKSSSKSKSSNESTSSSPDITSR-------------QANNNNTNSIGGHLPQNGTGGGVV 798
                        :|.|.:|....::..|             ....|....:|.|:...|     :
Zfish   942 ------------RSMNNNTEDFREVVKRLEHLTKGCETSEMTLRRNGLGQLGFHVNYEG-----I 989

  Fly   799 AAAVS----AAQNGV-----------VAVATMS 816
            .|.|.    |.|.|:           |||||:|
Zfish   990 VAEVEPYGYAWQAGLRQGSRLVEICKVAVATLS 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	5/20 (25%)
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	91/179 (51%)
sipa1l1	NP_001268721.1	Rap_GAP	643..823	CDD:280332	91/179 (51%)
		PDZ_signaling	969..1039	CDD:238492	15/59 (25%)
		SPAR_C	1496..1739	CDD:288714
		eNOPS_SF	<1727..1772	CDD:297912
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586370
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740