DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RapGAP1 and Garnl3

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	XP_038962112.1	Gene:	Garnl3 / 499783	RGDID:	1564019	Length:	1096	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	160/479 - (33%)
Similarity:	236/479 - (49%)	Gaps:	81/479 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 MNHSSSSTVSGSACSSTPASPQLSGVVSASGCQL--LSNGHHYQSQSSVSSNSSIVSAIPASQRL 280
            |.|..||:||...                 ||:.  .|..|:...:..:||::.  .||..:.|.
  Rat   100 MKHFCSSSVSEDL-----------------GCRRGDFSRKHYGSVELLISSDAD--GAIQRAGRF 145

  Fly   281 L-------EEALAKPAPYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTTWMAKFETDDTAKC 338
            .       |.|.|.|            |.|.....|      ..||.. .|.|
  Rat   146 RVENGSTDENAAALP------------GTWRRTDVH------LENPEY-HTRW------------ 179

  Fly   339 YRRFYAAREHSNLIGLDEQLGPILLSIKTENVANQ---EHMRILMRLRTGTMHELLPVSCLLPQP 400
            |.:::..:.|.|.||.|.:..|..||:...:..||   ::..||.| :|||....||.|     |
  Rat   180 YFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWR-KTGTQKICLPYS-----P 238

  Fly   401 SPAKMAHTLNENITVEHF----MPILCPKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFG 461
            :......::...:.::.|    ..|..|:..:.:.|.:|.....:||||||:.:.||.|::|:|.
  Rat   239 TKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFS 303

  Fly   462 NQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEG 526
            |:..|.||.:||::||..|.||...|||||||.:|..||..:||.|::..|:||||||:||:::.
  Rat   304 NEIGSEAFQKFLNLLGDTITLKGWTGYRGGLDTKNNTTGINSVYTVYQGHEVMFHVSTMLPYSKE 368

  Fly   527 DPQQLQRKRHIGNDIVAIVFQ---ETNTPFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTAR 588
            :.||::||||||||||.||||   |::..|.|.||.|||.|.|.:|:..:.|   ..|::.:.:.
  Rat   369 NRQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYDQQN---DNYRLKIFSE 430

  Fly   589 DDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEELREK 653
            :.||.|||.||:|.||...|||::|:|.||||.|.|..:...||:..:||...|:::|.::|..
  Rat   431 ESVPLFGPPLPSPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLYQDLMP- 494

  Fly   654 TRDFLGTDLSQTSAGSPTPETPKA 677
              |.....|::.|.....||:||:
  Rat   495 --DLHKNMLNRRSFSDVLPESPKS 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	87/181 (48%)
Garnl3	XP_038962112.1	Rap_GAP	302..480	CDD:396632	86/180 (48%)
Garnl3	XP_038962112.1	CNH	574..879	CDD:395630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345326
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845465at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850