DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RapGAP1 and sipa1l2

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	XP_009304425.1	Gene:	sipa1l2 / 497350	ZFINID:	ZDB-GENE-050208-66	Length:	1689	Species:	Danio rerio

Alignment Length:	798	Identity:	223/798 - (27%)
Similarity:	345/798 - (43%)	Gaps:	191/798 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VGSSEI---SLAPSSAASSPKPLHRMIKYWRNSS------------GKIPGLRKSES-------- 57
            :|:.::   ::.|::.|:    |||  :|...||            |.:.|.:...|
Zfish   123 IGAEDMDQTAINPNTGAT----LHR--EYGSTSSINRQGLPDEAFFGNLKGFQSEHSEQPSAPPP 181

  Fly    58 --FAEYRRHSSNSATISGGSGGRSSTSSARQLQYQRLEMESCENI-DMLTEPL----RRQHAFMA 115
              |.|:||:.:   |:|      .|..:|.|:  .|.::....|. |.:...|    .|:.:|:.
Zfish   182 HGFPEFRRYET---TVS------PSLQTAAQI--ARGDILCIPNYSDYVDSSLFYSREREKSFLQ 235

  Fly   116 NTQKQQPAGGGSGSGSVTHSPERLRGATTATQDLFELLERVQCSR----LDDQRC-----VLPAY 171
            ..:.::      |..|:      .|...|...:..:|.|...|||    |..|||     |....
Zfish   236 RQKSEK------GETSI------FRRLKTMKSEQRQLSELDDCSRHGRPLSFQRCFSHYDVQSVL 288

  Fly   172 FS--------------QNHHRGSNASEER-----------VPQPHSPHD--------SHAHPHNG 203
            |:              :|...|::|:.:.           :|...||.|        :...|..|
Zfish   289 FNISEAVTNRANLARRKNITTGASAASQHQISGALDGPDPLPLCESPLDNCEELGQKACTDPDEG 353

  Fly   204 GLQHSG---SRATLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQLLSNGHHYQSQSSVS 265
            ..:.||   |....|:.:.......::.:..:|.|.:                        |:|.
Zfish   354 DGKSSGLVLSCPYFRNEIGGEGERKLNATKPNSAPPN------------------------SNVG 394

  Fly   266 SNSSIVSAIP-----ASQRLLEEALAKPAPYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTT 325
            .|:||.|.:.     |...:||.:..                         .|.:|.|..:|:..
Zfish   395 DNNSIESTLSSHCTNAGVSVLEMSRE-------------------------NYASRENYAIPRDC 434

  Fly   326 WMAKF---ETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVAN-----QEHMRILMRL 382
             :.::   ..|..|..|.:|:..:||.|..|:||.|||:.:||:.|.:..     |.:.|::  .
Zfish   435 -IKRYIIEHIDMGAYYYHKFFFNKEHQNYFGVDENLGPVAVSIRREKLEEGKEGPQYNYRVI--F 496

  Fly   383 RTGTMHELLPVSCLLPQPSPAKMAHTLNENI----TVEHFMP---ILC-------PKASQLISVY 433
            |||.:..|.  ..:|....|:...|..:..:    .:|:.:|   |.|       ||..:.:...
Zfish   497 RTGELTTLR--GSILEDAVPSTAKHGTSRGLPLKEVLEYVVPEVNIQCLRMAISSPKVPEQLLKL 559

  Fly   434 DEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGH 498
            |:..|....|.|:||.:.||:||||::.|:..|||.|||||:||||:|||....||..||.:...
Zfish   560 DQQGLSYQHKVGILYCQAGQSTEEEMYNNESGSPALDEFLDLLGQRVRLKGFSKYRAQLDNKTDS 624

  Fly   499 TGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNT-PFSPDMIASHF 562
            ||..::|..:|:.|:||||||:||:|..:.|||.||||||||||.|:|||..: ||:|..|.|||
Zfish   625 TGTHSLYTTYKDFELMFHVSTMLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGSLPFTPQNIRSHF 689

  Fly   563 LHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYK 627
            .|.||:|:...|.|.|..|.::||...|||.|||.:|...:|.|...|::|:|.|:|||||:.:|
Zfish   690 QHVFIIVKVHNPCTEHVCYSIAVTRSKDVPAFGPLIPKGVMFPKSAVFRDFLLAKVINAENSAHK 754

  Fly   628 AEKFAKLEQRTRTSLLQNLCEELREKTR-DFLGTDLSQTSAGSPTPETPKAESGSGGNAGSRFID 691
            :|||..:..|||...|::|.|.....|. |..|...|..:.|:...|..:..:    ||......
Zfish   755 SEKFRAMATRTRQEYLKDLVENFTSATPVDASGPKFSFITLGAKRKERSRPRN----NAHLYSTG 815

  Fly   692 TVKKALIMRVRSQSVDTG 709
            .|..:::.|...||.|.|
Zfish   816 AVTWSVVARDSCQSSDIG 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	9/29 (31%)
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	91/179 (51%)
sipa1l2	XP_009304425.1	Rap_GAP	586..766	CDD:280332	91/179 (51%)
		PDZ_signaling	914..987	CDD:238492
		SPAR_C	1432..1633	CDD:288714
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586371
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740