Protein Alignment RapGAP1 and Rap1gap2

DIOPT Version :9

• Sequence 1: NP_001097114.2
• Gene: RapGAP1 / 34032
• FlyBaseID: FBgn0264895
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: XP_006533687.1
• Gene: Rap1gap2 / 380711
• MGIID: 3028623
• Length: 790
• Species: Mus musculus
• Alignment Length: 881
• Identity: 296/881 - (33%)
• Similarity: 417/881 - (47%)
• Gaps: 226/881 - (25%)

  Fly    76 GGRSSTSSARQLQYQRLEMESCENIDMLTEPLRRQHAFMANTQKQQPAGGGSGSGSVT-----HS 135
            |.|.||.:                  :|..|.|:|.  :||            |..||     .|
Mouse    72 GDRQSTPT------------------LLWRPARKQE--LAN------------SSDVTLPDRPLS 104

  Fly   136 PERLRGATTATQDLFELLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVPQPHSPHDSHAHP 200
            |......|..:.:.||:||::|..:|::||                      |.|....|.:
Mouse   105 PPLTAPPTMKSAEFFEMLEKMQGIKLEEQR----------------------PGPQKNKDDY--- 144

  Fly   201 HNGGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQLLSNGHHYQSQSSVS 265
                                                                             
Mouse   145 ----------------------------------------------------------------- 144

  Fly   266 SNSSIVSAIPASQRLLEEALAKPAPYPMILLPLHGGYWMD-----GTEHECG---YDARGNPLLP 322
                    ||...  ::|.:.|..|||:|:||..||||::     ||....|   |:......|.
Mouse   145 --------IPYPS--IDEVVEKGGPYPLIILPQFGGYWIEDPENVGTPTSLGSSVYEEEEEDSLS 199

  Fly   323 QTTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVANQEHMRILMRLRTGTM 387
            ..|:..|.|....|:.|||.:..::|.|.......||.::||||.|.....|::||::|.:..|:
Mouse   200 PNTFGYKLECRGEARAYRRHFLGKDHLNFYCTGSSLGNLILSIKCEEAEGMEYLRIILRSKLKTV 264

  Fly   388 HELLPVSCLLPQPSPAKMAHTLNENITVEHFMPILCPKASQLISVYDEHVLVSHFKFGVLYQRYG 452
            ||.:|::.|...||..::|....::.....|.|:|.|||||:|..||||.:.:.|||||:||:..
Mouse   265 HERIPLAGLSKLPSVPQIAKAFCDDAVGLKFNPVLYPKASQMIVSYDEHDVNNTFKFGVIYQKAR 329

  Fly   453 QTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHV 517
            ||.|||||||.:.||||.||||:||..|.|:|.||:|||||:.:|.||..:||..|::|||||||
Mouse   330 QTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHV 394

  Fly   518 STLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQPIEPNTPHTRYK 582
            ||.||.|:||.||||||||||||||||:|||.||||.||||||:||||:||||...|.|....||
Mouse   395 STKLPFTDGDTQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVVQADNPGTETPSYK 459

  Fly   583 VSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLC 647
            ||||||:|||.|||.||:|.||:||.||:||:||||.||||||.|::||||||.|||.:||.||.
Mouse   460 VSVTAREDVPAFGPPLPSPPVFQKGAEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNLH 524

  Fly   648 EELREKTRDFLGTDLSQTSAGSPTPETPKAESGSGGNAGSRFIDTVKKALIMRVRSQSVDTGNG- 711
            :||...|:..||..          ||..|.|:|..|.    |:::.|:|:  ||||.|::|..|
Mouse   525 DELHTHTQVMLGMG----------PEEDKFENGGHGG----FLESFKRAI--RVRSHSMETMVGS 573

  Fly   712 ----HG---PG-----------QTDKFSVNTKLGTLNSKKETHPEMQT-----PNLNT------C 747
                ||   ||           :..|.:.:..:....:|.::...::.     |.|::      .
Mouse   574 QRKLHGGNLPGSLSGGIVHNSMEVTKTTFSPPVAAATAKNQSRSPIKRRSGLFPRLHSGSEGQGD 638

  Fly   748 SRTASKSSSKSKSSNESTSSSPDITSRQANNNNTNSIGGH-------LPQNGTGGGVVAAAVSAA 805
            |||...|:|.:..:.:...||.:|.|..::|.::..|..:       |.:||      .|.:|.:
Mouse   639 SRTRCDSASSTPKTPDGGHSSQEIKSETSSNPSSPEICPNKEKPFIKLKENG------RANISRS 697

  Fly   806 QNGVVAVATMSETSDDSSLNSVDLDPMMAHLDGGATYIDSDTGLES---MSSAEATTKACSLCLD 867
            .:   :.::.|.|:.:..        .|...|.|::...:.:..:.   ..|...::::.||
Mouse   698 SS---STSSFSSTAGEGE--------AMEECDSGSSQPSTTSPFKQEVFAYSPSPSSESPSL--- 748

  Fly   868 GVQST--IMGSSPSNETIVKIENLRQEVTRLKCDKL 901
            |..:|  ||..||   |..|..|..:...:.:.|||
Mouse   749 GAAATPIIMSRSP---TDAKSRNSPRSNLKFRFDKL 781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	8/20 (40%)
		Rap_GAP	460..639	CDD:280332	125/178 (70%)
Rap1gap2	XP_006533687.1	Rap_GAP	337..516	CDD:366939	125/178 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841930
Domainoid	1	1.000	262	1.000	Domainoid score	I1932
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	461	1.000	Inparanoid score	I1551
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163377at33208
OrthoFinder	1	1.000	-	-		FOG0002359
OrthoInspector	1	1.000	-	-		otm42989
orthoMCL	1	0.900	-	-		OOG6_105084
Panther	1	1.100	-	-	O	PTHR15711
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1559
SonicParanoid	1	1.000	-	-		X1790
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790