DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RapGAP1 and Sipa1

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001004089.1	Gene:	Sipa1 / 361710	RGDID:	1303184	Length:	1040	Species:	Rattus norvegicus

Alignment Length:	714	Identity:	217/714 - (30%)
Similarity:	288/714 - (40%)	Gaps:	233/714 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 GGSGSGSVTHSPERLRG-ATTATQDLFELLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVP 188
            ||.|      ||.  || |...|.|||                               |.:.|.|
  Rat     4 GGVG------SPR--RGMAPAPTDDLF-------------------------------ARKLRQP 29

  Fly   189 --QPHSPHDSHAHPHNGGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQL 251
              .|.:||.....|..|.|..|||.|               |.....|||||:
  Rat    30 ARPPLTPHTFEPRPARGPLLRSGSDA---------------GEVRPPTPASPR------------ 67

  Fly   252 LSNGHHYQSQSSVSSNSSIVSAIPASQRLLEEALA-------KPAP-YPMILLP----------- 297
             :..|.::       ::|..:|.|.  ||..:.||       :|.| :|.:|.|
  Rat    68 -ARAHSHE-------DTSRPAATPT--RLFTDPLALLGLPAEEPEPTFPPVLEPRWFAHYDVQSL 122

  Fly   298 ----------------------------------LHG--GYWMD-GTEHECGYDARGNPLLP--- 322
                                              |.|  |:..: |.|.|.|.   |.|:.|
  Rat   123 LFDWAPRPRATGSHTESNSGTLALAEDQTTTSDLLLGAPGFVSELGGEGELGL---GGPISPPVP 184

  Fly   323 ----------------QTTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVA 371
                            :||..:....|..|..||:::..:||.|..||||.|||:.:|::.|...
  Rat   185 PALPNASVSVLEEPQTRTTAYSLEHADLGAGYYRKYFYGKEHQNFFGLDEALGPVAVSLRREEKE 249

  Fly   372 NQ-----EHMRILMR---LRT--GTMHELLPVSCLLPQP----SPAKMAHTLNENITVEHFMPIL 422
            ..     ...|:::|   |||  ||:.|    ..|.|.|    ||.|:         :||..|.|
  Rat   250 GSGGGTLHSYRVIVRTTQLRTLRGTISE----DALPPGPPRGLSPRKL---------LEHVAPRL 301

  Fly   423 ---C-------PKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLG 477
               |       ||..:.:...||.||....|.|:||.|.||.:|||::.||:...||.:||.:||
  Rat   302 SPTCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGAAFMQFLTLLG 366

  Fly   478 QRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIV 542
            ..:|||..:.||..||.:...||..::|..:::.||||||||:||:|..:.|||.||||||||||
  Rat   367 DVVRLKGFENYRAQLDTKTDSTGAHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIV 431

  Fly   543 AIVFQETNT-PFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLP-NPAVFR 605
            .|||||..: ||.|..|.|||.|.|:||:...|.||||.|:|:|:...|.|.|||.|| ....|.
  Rat   432 TIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHAPCTPHTSYRVAVSRTQDTPAFGPALPEGGGPFA 496

  Fly   606 KGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSA-GS 669
            ...:|:.|:|.|.:|.|.|...|.:|..:..|||...||:|.      |.:...|.|...|. |.
  Rat   497 ANADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA------TNEVTTTSLDSASRFGL 555

  Fly   670 P--------TPETPKAESGSGGNAGSRFIDTVKKALIMRVR-------SQSVDTGNGHGPGQTD 718
            |        ||.:|.||..:.|            ||:..||       |...:||   ||...:
  Rat   556 PSLGGRRRATPRSPGAELQAAG------------ALMWGVRAAPGARVSAGAETG---GPDHAE 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	3/20 (15%)
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	84/180 (47%)
Sipa1	NP_001004089.1	Rap_GAP	349..530	CDD:280332	84/180 (47%)
		PDZ	685..757	CDD:278991
		DUF904	972..1028	CDD:283624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345325
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740