Protein Alignment RapGAP1 and rsh

DIOPT Version :10

• Sequence 1: NP_001097114.2
• Gene: RapGAP1 / 34032
• FlyBaseID: FBgn0264895
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: XP_061500025.1
• Gene: rsh / 3290563
• VectorBaseID: AGAMI1_011524
• Length: 1556
• Species: Anopheles gambiae
• Alignment Length: 1074
• Identity: 276/1074 - (25%)
• Similarity: 419/1074 - (39%)
• Gaps: 288/1074 - (26%)

  Fly    26 SSAASSPK-PLHRMIKYWRNSS--GKIPGLRKSESFAEYRRHSSNSATISGGSGGRSSTSSARQL 87
            ||||..|: |........|::|  .:.|...:|.:....||.|:....:......|.||:.
Mosquito   429 SSAARQPRSPDSSSCCSSRDASPCARPPPPTESTARPSIRRQSTTEEILIARGFRRQSTTE---- 489

  Fly    88 QYQRLEMESCENIDMLTEPLRRQHAFMANTQKQQPAGGGSGSGSVTHSPERLRGAT-TATQDLFE 151
                 ||..|.|       .|||.:...:|.:.:        |....|.:.:.|.. |.|.:...
Mosquito   490 -----EMIRCRN-------FRRQSSQSDDTSRYR--------GRRDSSAQIIDGTIGTMTVETTS 534

  Fly   152 LLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVPQP----HSPHDSHAHPHNGGLQHSG-SR 211
            .|.|:                    |..|..|.|..|.|    :..|:.....::.||..:| ::
Mosquito   535 KLRRL--------------------HGSSQQSHESEPSPLYENNHYHEECLRCNSCGLNLTGPNQ 579

  Fly   212 ATLRHSMN------HSSSSTVSGSACSS-----TPASPQLSGVVSASGCQLLSNGHHYQSQSSVS 265
            ...|...|      |.:.  |:...||.     ....||      :.||.:...          .
Mosquito   580 KRARRFKNQILCDLHFAD--VALMECSDFMQQLRSFKPQ------SLGCAVARR----------K 626

  Fly   266 SNSSIVSAIP---ASQRLLEEALAKPAPYPMILLPLHGGYWM----------------DGTEHEC 311
            |:::::..:|   .|....|:       ||..|:|. .|||:                |.:|.|.
Mosquito   627 SSTTLIFPLPPQACSDEFCED-------YPHNLIPT-PGYWIECSRQKIAFPNQHTIWDDSESEH 683

  Fly   312 GYDARGNPLLPQ--------------------------------TTWMAK--FE-TDDTAKCYRR 341
            ...|||..:.||                                ..|..:  || |....:.|.:
Mosquito   684 EEAARGITVEPQLERNCSDLYEDDEDSDNVPSSQRFRRKKTAIEEQWEQQQGFELTSVEQETYEK 748

  Fly   342 FYAAREHSNLIGLDEQLGPILLSIKTENVANQEHMRILMRLRTGTMHELLPVSCLL-PQPSPAKM 405
            ::...||.|....||.|||::||||.|.:..::..|||:|..:.|:|.|:|.||:. .:.:..::
Mosquito   749 YFYGTEHWNYFTNDEDLGPVILSIKQETINGRDQFRILVRAISYTVHGLIPASCVFADRYNREEV 813

  Fly   406 AHTLNENITVEHFMPIL----CPKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTS 466
            ..:|.:.:.:.   |.|    .|...:.:...|:..:.|..|.||:|.:.||.|||::..|.:.|
Mosquito   814 VRSLGKEVNLN---PPLTLGQLPDTPEELLKLDQVFIKSELKVGVIYVKEGQYTEEQILDNNENS 875

  Fly   467 PAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQL 531
            |.|:|||.:||.::||:....|:||||..:..||..:||..::..||||||||.||:.:.|||:|
Mosquito   876 PLFEEFLQLLGDKVRLRGFDKYKGGLDTVHDLTGLYSVYTNWRSIEIMFHVSTQLPYEKHDPQKL 940

  Fly   532 QRKRHIGNDIVAIVFQET-NTPFSPDMIASHFLHAFIVVQ-PIEPNTPHTRYKVSVTARDDVPFF 594
            |||||||||||.:||.|. ||.|||..|.|||||.||:|: ........|||:|||..||:|..:
Mosquito   941 QRKRHIGNDIVCVVFLEADNTAFSPACIKSHFLHTFILVRVSARIKRKPTRYEVSVVTRDEVGAY 1005

  Fly   595 GPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEELREKTRD--- 656
            .|.|...:||.||..|:|::|||::|.|.|.|.|.|||::::|||:.:|:::...|......
Mosquito  1006 KPYLWEQSVFEKGPMFREWLLTKIVNGERASYSAPKFARMQERTRSQMLEDIVANLANHAETGQI 1070

  Fly   657 --------------FLGTD---LSQTSAG--------SPTPETP--------------------- 675
                          .:.||   ||.|.:|        ...|.:|
Mosquito  1071 PKPYRRGSWRPIDILMHTDSHILSHTDSGFLIRNCTRHMRPSSPLLDSVRDQFEDYDQLAKDFTR 1135

  Fly   676 ---KAESGSGGNA--------------GSRFIDTVKKALIMRVRSQSVDTGNGHGPGQTDKFSVN 723
               .:|.....||              .:|||..   ..|:.|||:..         |...:.:.
Mosquito  1136 VFLNSEPSCLQNAQLFDVVFLVGQSKQRARFIGV---RAILGVRSRVF---------QEMLYGIQ 1188

  Fly   724 TKLGTLNSKKETHPEMQTPNLNTCSRTA----SKSSSKSKSSNESTSSSPDITSRQANNNNTNSI 784
            |..|:          .|.|.....:|.|    |..:.:.||||  ....|||.|.:
Mosquito  1189 TGFGS----------PQVPVAELLARPAPTLLSPQNQRPKSSN--FLQVPDIESPR--------- 1232

  Fly   785 GGHLPQNGTGGGVVAAAVSAAQNGVVAVATMSETSDDSSLNSVDLDPMMAHLDGGATYIDSDTGL 849
                |::.....:|..|.|.. ..:.|....|.....:.||:.|.....:..|..    |.| |.
Mosquito  1233 ----PKSVPSSPMVKRAFSRL-GTITAGWGRSIRKQHTQLNAEDKKKWASSQDCS----DKD-GK 1287

  Fly   850 ESMSSAEA-----TTKACSLCLDGVQSTIMGSSPSNETIVKIENLRQEVTRLKCDKLDLLRQNVT 909
            |:.|.::|     .....|:|.|..:......:.:..||::.:   .:..|:..|.|......:|
Mosquito  1288 ETSSKSKANAGQLAVPRLSVCADAQKVDRAKLAQTEFTIIEFD---PDTFRVLLDYLHTGSCPLT 1349

  Fly   910 CQRDIKRLRERELSLQGDLSAAGREILRLRDLLK 943
            |           .|:.|.:.||  |...|.:||:
Mosquito  1350 C-----------TSIPGLICAA--EHYDLPELLQ 1370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:460481	2/20 (10%)
		Rap_GAP	460..639	CDD:460463	91/180 (51%)
rsh	XP_061500025.1	None