DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RapGAP1 and rad

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001285176.1	Gene:	rad / 32253	FlyBaseID:	FBgn0265597	Length:	1799	Species:	Drosophila melanogaster

Alignment Length:	880	Identity:	240/880 - (27%)
Similarity:	365/880 - (41%)	Gaps:	221/880 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SLAPSSAASSPKPLHRMIKYWRNSSGKIPGLRKSESFAEYRRHSSNSATISGGSGGRSSTSSARQ 86
            ||:|.||:...:         |:|...:...|..|.....|||:....:.|.....||..|::
  Fly   421 SLSPDSASRGGR---------RDSRTHLSPDRSHERDGSPRRHTLRRQSSSAARSPRSPDSNS-- 474

  Fly    87 LQYQRLEMESCENIDMLTEPLRRQHAFMANTQKQQPAGGGSGSGSVTHSPERLRGATTATQDLFE 151
                     .|.:.|  ..|..|........|.|:||               :|..:|..:.|..
  Fly   475 ---------CCSSRD--PSPCSRPQTQTTVEQNQRPA---------------IRRQSTTEEILIA 513

  Fly   152 LLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVPQPHSPHDSHAHPHNGGLQHSGSRATLRH 216
            ...|.|.:..:..||       :|..|.|:.|:: |.:.....||.|...:|.:          .
  Fly   514 RGFRRQSTTEEMIRC-------RNFRRQSSQSDD-VCRYRGRRDSSAQIIDGTI----------G 560

  Fly   217 SMNHSSSSTVSGSACSSTPASPQLSG------VVSASGC-----------------QLLSNGH-- 256
            :|...::||...|:..:.| ||....      .:..:.|                 |:|.:.|
  Fly   561 TMTVETTSTFFDSSTQTEP-SPLYDNNHYHEECLRCNSCGLNLTGPNQKRARRFKNQILCDLHFA 624

  Fly   257 ---------------HYQSQS---SVS---SNSSIVSAIP---ASQRLLEEALAKPAPYPMILLP 297
                           .::.||   :|:   |:::::..:|   .|....||       ||..|:|
  Fly   625 DVALMECSDFMQQLRSFKPQSLGCAVARRKSSTTLIFPLPPQACSDEFCEE-------YPHNLMP 682

  Fly   298 LHGGYWMDGTEHECGYDARGNPLLPQTTWMAK------------------------FETDDTAKC 338
            . .|||:     ||.......| .|.|.|...                        :|.|:.::.
  Fly   683 T-PGYWI-----ECSRQKITMP-TPHTIWDESDSEHEDIRAGSASDAYLERECSDLYEDDEDSEA 740

  Fly   339 -----------------------------YRRFYAAREHSNLIGLDEQLGPILLSIKTENVANQE 374
                                         |.:::...||.|....||.|||::||||.|.:..::
  Fly   741 TPSPRKKTTIEEQWDQQGAFELISVEQETYEKYFYGTEHWNYFTSDEDLGPVILSIKQETLNGRD 805

  Fly   375 HMRILMRLRTGTMHELLPVSCLL-PQPSPAKMAHTLNENITVEHFMPIL----CPKASQLISVYD 434
            ..|||:|..:.|:|.|:|.||:. .:.:..::..:|.:.:.:.   |.|    .|...:.:...|
  Fly   806 QFRILVRAGSYTVHGLIPASCVFADRYNREEVVRSLGKEVNLN---PPLTLGQLPDTPEELLKLD 867

  Fly   435 EHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHT 499
            :..:.|..|.||::.:..|.|||::..|.:.||.|||||.:||.|:||:....|:||||..:..|
  Fly   868 QVFIKSELKVGVIFVKEDQYTEEQILDNNENSPLFDEFLTLLGDRVRLRGFDKYKGGLDTVHDLT 932

  Fly   500 GDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQET-NTPFSPDMIASHFL 563
            |..:||..::..|||||||||||:.:.|||:||||||||||||.:||.|. ||.|||..|.||||
  Fly   933 GLFSVYTNWRNIEIMFHVSTLLPYEKHDPQKLQRKRHIGNDIVCVVFLEADNTRFSPACIKSHFL 997

  Fly   564 HAFIVVQPIEPNTPH--TRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACY 626
            |.||:|: :.....|  |||:|||..||:|..:.|.|...:||.||..|:|::|||::|.|.|.|
  Fly   998 HTFILVR-VSARIKHKPTRYEVSVVTRDEVGAYKPYLWEQSVFEKGPMFREWLLTKIVNGERASY 1061

  Fly   627 KAEKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSAGSPTPETPKA-ESGSGGNAGSRFI 690
            .|.|||::::|||:.:|::|...|               |..:.|.:.||. ..||....|.
  Fly  1062 SAPKFARMQERTRSQMLEDLVMNL---------------SNHAETGQIPKPYRRGSWRPIGE--- 1108

  Fly   691 DTVKKALIMRVRSQSVDTGNGHGPGQTDKFSVNTKLGTLNSKKETHPEMQTPNLNTC-------S 748
            |...|.|..||    :|....|...|       ..|......:.|......|:.|.|       :
  Fly  1109 DEYIKMLHARV----LDNNTHHEQQQ-------QLLLQQQHMQHTQHMQHLPSHNICCYCNNNAT 1162

  Fly   749 RTASKSSSKSKSSNESTSSSPDITSRQANNNNTNS 783
            ...:..:..:.:.|.:|:::...|.|..||||..|
  Fly  1163 ELHTAGAIHNNNDNNNTTTTTTFTHRHNNNNNNYS 1197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	5/20 (25%)
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	95/181 (52%)
rad	NP_001285176.1	LIM	<583..623	CDD:259829	3/39 (8%)
		Rap_GAP	893..1074	CDD:280332	95/181 (52%)
		BTB	<1464..1523	CDD:295341
		BTB	<1467..1526	CDD:197585
		BACK	1544..1646	CDD:197943
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163377at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR15711
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020