DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RapGAP1 and Rap1gap

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001094183.1	Gene:	Rap1gap / 313644	RGDID:	1309908	Length:	753	Species:	Rattus norvegicus

Alignment Length:	831	Identity:	298/831 - (35%)
Similarity:	411/831 - (49%)	Gaps:	218/831 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 DLFELLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVPQPHSPHDSHAHPHNGGLQHSGSRA 212
            ||||::|::|.||:|:|||..|...        ...|:.:|.| |.|
  Rat    61 DLFEMIEKMQGSRMDEQRCSFPPPL--------KTEEDYIPYP-SVH------------------ 98

  Fly   213 TLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQLLSNGHHYQSQSSVSSNSSIVSAIPAS 277

  Rat    99 ----------------------------------------------------------------- 98

  Fly   278 QRLLEEALAKPAPYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTTWMAKFETDDTAKCYRRF 342
                 |.|.:..|:|:||||..||||::||.||........||...|| ..|.|.:.||:.||:.
  Rat    99 -----EVLGREGPFPLILLPQFGGYWIEGTNHEISSIPETEPLQSPTT-KVKLECNPTARIYRKH 157

  Fly   343 YAAREHSNLIGLDEQLGPILLSIKTENVANQEHMRILMRLRTGTMHELLPVSCLLPQPSPAKMAH 407
            :..:||.|...||..||.::.|:|.:.:.:|||:|:|:|.:..|.|:::|:|||...|:..:||.
  Rat   158 FLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAK 222

  Fly   408 TLNENITVEHFMPILCPKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEF 472
            .:.|::.|:.|.|:|.||||:||..:||||:.::|||||:||:.|||:|||||...:.||||.||
  Rat   223 LVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEF 287

  Fly   473 LDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHI 537
            |:.|||:::|:|.||:|||||:.:|.||..:||..|:.:||||||||.||:||||.|||||||||
  Rat   288 LEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHI 352

  Fly   538 GNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPA 602
            ||||||:|||:.||||.||||||:||||::|||..........||||||||||||||||.||:||
  Rat   353 GNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPA 417

  Fly   603 VFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEEL----------------- 650
            |||||.||:||:||||||||.||||||||||||:|||.:||:.|.|||
  Rat   418 VFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKM 482

  Fly   651 -------------------REKTRDFLG------TDLSQTSAGSPTPETPKAESGSG------GN 684
                               |.::.|.:|      ..:|.:.:||.||..|.....:|      |.
  Rat   483 ENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLLIPGK 547

  Fly   685 AGSRF--------IDTVKKALIMRVRSQSVDTGNGHGPGQTDKFSVNTKLGTLNSKKETHPEMQ- 740
            :.|||        |..|:::||:..:|.:.......|..::....:. .:..:..|:|:.|..|
  Rat   548 SASRFGRRGSALGIGAVEESLIVPGKSPTRKKSGPFGSRRSSAIGIE-NIQEVQEKRESPPAGQK 611

  Fly   741 TPNLNTCSRTASKSSSKSKSSNESTSSSPDITSRQANNNNTNSIGGHLPQNGTGGGVVAAAVSAA 805
            ||:       :...|.:.||.|.||.|||::.:.:      |.:                 .|||
  Rat   612 TPD-------SGHVSQEPKSENSSTQSSPEMPTTK------NRV-----------------ESAA 646

  Fly   806 QNGVVAVATMSETSDDSSLNSVDLDPMMAHLDGGATYID-SDTGLESMSSAEATTKACSLCL--- 866
            |...|.......:|..||..||     :...:|    :| .|||:||:||:....|..|...
  Rat   647 QRTEVLQGFSRSSSSASSFTSV-----VEETEG----VDGDDTGMESVSSSGTPHKRDSFLYSTW 702

  Fly   867 --DGVQSTIMGSSPS-----------------NETIVKIENLRQEVTRLKC 898
              |.|.:|..||||.                 .|..:::|...|...::.|
  Rat   703 LDDSVSTTSGGSSPGLTRSPHPDAVKSGDPACPEIKIQLETSEQHTPQMGC 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	12/19 (63%)
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	125/178 (70%)
Rap1gap	NP_001094183.1	GoLoco	61..81	CDD:214645	12/19 (63%)
Rap1gap	NP_001094183.1	Rap_GAP	275..454	CDD:280332	125/178 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345330
Domainoid	1	1.000	262	1.000	Domainoid score	I1876
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	488	1.000	Inparanoid score	I1368
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163377at33208
OrthoFinder	1	1.000	-	-		FOG0002359
OrthoInspector	1	1.000	-	-		otm45053
orthoMCL	1	0.900	-	-		OOG6_105084
Panther	1	1.100	-	-	LDO	PTHR15711
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1790
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760