Protein Alignment RapGAP1 and Rap1gap2

DIOPT Version :10

• Sequence 1: NP_001097114.2
• Gene: RapGAP1 / 34032
• FlyBaseID: FBgn0264895
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: XP_017452778.1
• Gene: Rap1gap2 / 303298
• RGDID: 1304590
• Length: 808
• Species: Rattus norvegicus
• Alignment Length: 840
• Identity: 299/840 - (35%)
• Similarity: 432/840 - (51%)
• Gaps: 120/840 - (14%)

  Fly   122 PAGGGSGSGSVTHSPERLRGATTATQDLFELLE-RVQCSRLDDQRCVLPAY---FSQNHHRGSNA 182
            |...|:.|.:...:.:.:.|.....::.::|:. .:|..|...:...|.|:   :|...||..:.
  Rat    20 PTAAGAASAAQGAAGQGMAGRRAPGENRWQLVRWYIQEGRFRIEERTLTAFQWLYSPQQHRILSR 84

  Fly   183 SEERVPQPHSPHDSHAHPHNGGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSG---VV 244
            ::...|   |..|.   ....||:      ..:..:.:||..|:     ...|.||.|:.   :.
  Rat    85 ADLESP---SRIDK---TMLAGLK------VKKQELANSSDVTL-----PDRPLSPPLTAPPTMK 132

  Fly   245 SASGCQLLS--NGHHYQSQ-SSVSSNSSIVSAIPASQRLLEEALAKPAPYPMILLPLHGGYWMD- 305
            ||...::|.  .|...:.| .....|.......|:    :||.:.|..|||.|:||..||||::
  Rat   133 SAEFFEMLEKMQGIKLEEQRPGPQKNKEDYIPYPS----IEEVVEKGGPYPQIILPQFGGYWIED 193

  Fly   306 ----GTEHECG---YDARGNPLLPQTTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILL 363
                ||....|   |:......|...|:..|.|....|:.|||.:..::|.|.......||.::|
  Rat   194 PENVGTPTSLGSSVYEEEEEDSLSPNTFGYKLECRGEARAYRRHFLGKDHLNFYCTGSSLGNLIL 258

  Fly   364 SIKTENVANQEHMRILMRLRTGTMHELLPVSCLLPQPSPAKMAHTLNENITVEHFMPILCPKASQ 428
            |||.|.....|::||::|.:..|:||.:|::.|...||..::|....::.....|.|:|.|||||
  Rat   259 SIKCEEAEGIEYLRIILRSKLKTVHERIPLAGLSKLPSVPQIAKAFCDDAVGLKFNPVLYPKASQ 323

  Fly   429 LISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLD 493
            :|..||||.:.:.|||||:||:..||.|||||||.:.||||.||||:||..|.|:|.||:|||||
  Rat   324 MIVSYDEHDVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLD 388

  Fly   494 IQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDMI 558
            :.:|.||..:||..|::|||||||||.||.|:||.||||||||||||||||:|||.||||.||||
  Rat   389 VTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDTQQLQRKRHIGNDIVAIIFQEENTPFVPDMI 453

  Fly   559 ASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAEN 623
            ||:||||:||||.....|....||||||||:|||.|||.||:|.||:||.||:||:||||.||||
  Rat   454 ASNFLHAYIVVQAESTGTETPSYKVSVTAREDVPAFGPPLPSPPVFQKGTEFREFLLTKLTNAEN 518

  Fly   624 ACYKAEKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSAGSPTPETPKAESGSGGNAGSR 688
            ||.|::||||||.|||.:||.||.:||...|:..||..          ||..|.|:|..|.
  Rat   519 ACCKSDKFAKLEDRTRAALLDNLHDELHTHTQVMLGMG----------PEEDKFENGGHGG---- 569

  Fly   689 FIDTVKKALIMRVRSQSVDTGNG-----HG---PGQTD-------------KFSVNTKLGTLNSK 732
            |:::.|:|:  ||||.|::|..|     ||   ||...             .||......|:.::
  Rat   570 FLESFKRAI--RVRSHSMETMVGSQRKLHGGNIPGSLSGGIVHNSMEVTKTTFSPPVAAATVKNQ 632

  Fly   733 KETHPEMQT---PNLNT------CSRTASKSSSKSKSSNESTSSSPDITSRQANNNNTNSIGGH- 787
            ..:..:.::   |.|::      .|||...|:|.:..:.:...||.:|.|..::|.::..|..:
  Rat   633 SRSPIKRRSGLFPRLHSGSEGQGDSRTRCDSASSTPKTPDGGHSSQEIKSETSSNPSSPEICPNK 697

  Fly   788 ------LPQNGTGGGVVAAAVSAAQNGVVAVATMSETSDDSSLNSVDLDPMMAHLDGGATYIDSD 846
                  |.:||      .|.:|.:.:   :.::.|.|:.:..        .|...|.|::...:.
  Rat   698 EKPFIKLKENG------RANISRSSS---STSSFSSTAGEGE--------AMEECDSGSSQPSTT 745

  Fly   847 TGLES---MSSAEATTKACSLCLDGVQST--IMGSSPSNETIVKIENLRQEVTRLKCDKL 901
            :..:.   :.|...::::.||   |..:|  ||..||   |..|..|..:...:.:.|||
  Rat   746 SPFKQEVFVYSPSPSSESPSL---GAAATPIIMSRSP---TDAKSRNSPRSNLKFRFDKL 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:460481	3/21 (14%)
		Rap_GAP	460..639	CDD:460463	124/178 (70%)
Rap1gap2	XP_017452778.1	Rap_GAP	355..534	CDD:460463	124/178 (70%)