DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RapGAP1 and Sipa1l3

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001358027.1	Gene:	Sipa1l3 / 292771	RGDID:	1311432	Length:	1776	Species:	Rattus norvegicus

Alignment Length:	969	Identity:	251/969 - (25%)
Similarity:	385/969 - (39%)	Gaps:	252/969 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PSS--AASSPKPLHRMIKY----------WRNSSGKIPGLRKSESFAEYRRHSSNSATIS----G 73
            |||  |:|..:..||:.:.          |..|.|:        :|...|..||:..|:|    .
  Rat   120 PSSTPASSGSRAFHRLSRRRSKDVEFQDGWPRSPGR--------AFLPLRHRSSSEITLSECDVE 176

  Fly    74 GSGGRSSTSSARQLQYQRLEMESCENIDMLTEPLRRQHAFMANTQKQQPAGGGS----------- 127
            ..|....|.....|...| |..|..:||:...|.:.....:...:.:||...||
  Rat   177 EPGDPRGTRHPGVLPLFR-EYGSTSSIDVQGVPEQSFFDILNEFRSEQPEARGSQNLSELLRVDP 240

  Fly   128 -----GSGSVTHSPERLRGATTATQDLFELLERVQCSR-----LDDQRCVLPAYFSQNHHRGSNA 182
                 ||......|...:....:.|.|..|.|:.:..:     |.....|..:.|.:..   |:.
  Rat   241 GALSGGSCGAKGDPRNGQPTKDSLQSLQPLKEKEKARKKPVRGLGSGDTVDSSIFRKLR---SSK 302

  Fly   183 SEERVPQP-------HSPHD---------SHAH-PHNGGLQHSGSRATLRHSMNHSSSSTVSGSA 230
            .|..|.:|       .||.:         |.|| .....|......|..|.|:....::|...||
  Rat   303 PEGEVGRPLGETEEGRSPPEASRPWVCQKSFAHFDVQSMLFDLNEAAANRVSVAQRRNTTTGASA 367

  Fly   231 CSSTPASPQLSGVVSAS--------------GCQ--------------LLSNGHHYQ-------- 259
            .|:..|...|:...:.|              .|:              ||.:..|::
  Rat   368 ASAASAMVALTASRAHSLGTLDPTFTSTEDLNCKENLEQDLGDDNSNDLLLSCPHFRNEIGGERE 432

  Fly   260 -----SQSSVSS-------------------NSSI-VSAIPASQRLLEEALAKPAPYPMILLPLH 299
                 |::||.|                   |:|| |..:|..|   :...::|..|.:
  Rat   433 RNVSFSRASVGSPGGSSEAHMAEPALSTHRTNASISVLEVPKEQ---QRTQSRPRQYSI------ 488

  Fly   300 GGYWMDGTEHECGYDARGNPLLPQTTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLS 364
                    ||                      .|..|:.|:.::..:||:|..|:||:|||:.:|
  Rat   489 --------EH----------------------VDLGARYYQDYFVGKEHANYFGVDEKLGPVAVS 523

  Fly   365 IKTENVAN------QEHMRILMRLRTGTMHELLPV-SCLLPQPSPAKMAHTLNENI----TVEHF 418
            ||.|.:.:      |...||:.|.|     ||:.: ..:|...:|....|.....:    .:|:.
  Rat   524 IKREKLEDHKDHGPQYQYRIIFRTR-----ELITLRGSILEDATPTATKHGTGRGLPLKDALEYV 583

  Fly   419 MP---ILC-------PKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFL 473
            :|   |.|       ||.::.:...||..|....|.|:||.:.||::|||::.|::..|||:|||
  Rat   584 IPELNIHCLRLALNTPKVTEQLLKLDEQGLCRKHKVGILYCKAGQSSEEEMYNNEEAGPAFEEFL 648

  Fly   474 DVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIG 538
            |:||.::.||....|...||::...||..::|..:::.|||||||||||:|..:.|||.||||||
  Rat   649 DLLGDKVCLKGFTKYAAQLDVKTDSTGTHSLYTTYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIG 713

  Fly   539 NDIVAIVFQETNT-PFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPA 602
            ||||.|:|||... ||:|..|.|||.|.||:|:...|.|.:..|.::||...|.|.|||.:||..
  Rat   714 NDIVTIIFQEPGALPFTPKNIRSHFQHVFIIVRVHNPCTENVCYSMAVTRSKDAPPFGPPIPNGT 778

  Fly   603 VFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSA 667
            .|||...|::|:|.|:||||||.:|::||..:..|||...|::|.|.....|........:..|.
  Rat   779 TFRKSDVFRDFLLAKVINAENAAHKSDKFHTMATRTRQEYLKDLAENCVSNTPIDSSGKFNLISL 843

  Fly   668 GSPTPETPKAESGSGGNAGSRFIDTVKKALIMRVRSQSVDTGNGHGPGQTDKFSVNTKLGTLNSK 732
            .|...|..||.:|:..::..        |:..||.:|....|:          .::..|| ::::
  Rat   844 TSKKKEKTKARAGAEQHSAG--------AVAWRVAAQDYAQGS----------EIDCILG-ISNE 889

  Fly   733 KETHPEMQTPNL-------NTCSRTASKSSSK----------SKSSNESTSSSPDITSR-QANNN 779
            .....:::|..:       :....|...|:.|          .:::..|.....||..| :...|
  Rat   890 FVVLLDLRTKEVVFNCYCGDVIGWTPDSSTIKIFYGRGDHIFLQAAEGSVEDIRDIVQRLKVMTN 954

  Fly   780 NTNSIGGHLPQNGTG--------GGVVAAAVS---AAQNGV-----------VAVATMS 816
            ...::...|.:||.|        .|.||....   |.|.|:           |||.|:|
  Rat   955 GWETVDMTLRRNGLGQLGFHVKYDGTVAEVEDYGFAWQAGLRQGSRLVEICKVAVVTLS 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	5/25 (20%)
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	87/179 (49%)
Sipa1l3	NP_001358027.1	Rap_GAP	635..815	CDD:396632	87/179 (49%)
		PDZ_signaling	960..1030	CDD:238492	15/54 (28%)
		PHA03247	<1065..1706	CDD:223021
		SPAR_C	1471..1721	CDD:403176
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345327
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740