DRSC/TRiP Functional Genomics Resources

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Protein Alignment RapGAP1 and SIPA1L3

DIOPT Version :10

Sequence 1:NP_001097114.2 Gene:RapGAP1 / 34032 FlyBaseID:FBgn0264895 Length:959 Species:Drosophila melanogaster
Sequence 2:NP_055888.1 Gene:SIPA1L3 / 23094 HGNCID:23801 Length:1781 Species:Homo sapiens


Alignment Length:853 Identity:226/853 - (26%)
Similarity:349/853 - (40%) Gaps:240/853 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 VDHGHPIIVGSSEISLAPSS--AASSPKPLHRMIKY----------WRNSSGKIPGLRKSESFAE 60
            :.:|.|           |:|  |:|..|..||:.:.          |..|.|:        :|..
Human   120 IQNGQP-----------PTSTPASSGSKAFHRLSRRRSKDVEFQDGWPRSPGR--------AFLP 165

  Fly    61 YRRHSSNSATIS-------GGSGGRSSTSSARQLQYQRLEMESCENIDMLTEPLRRQHAFMANTQ 118
            .|..||:..|:|       |...|...|.:....:    |..|..:||:...|.:.....:...:
Human   166 LRHRSSSEITLSECDAEDAGEPRGARHTGALPLFR----EYGSTSSIDVQGMPEQSFFDILNEFR 226

  Fly   119 KQQP--------------------AGGGSGSGSVTHS-----------------------PER-L 139
            .:||                    .|||.|:...:|:                       |.| |
Human   227 SEQPDARGCQALTELLRADPGPHLMGGGGGAKGDSHNGQPAKDSLLPLQPTKEKEKARKKPARGL 291

  Fly   140 RGATTATQDLFELLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVP----QPHSPHDSHAH- 199
            .|..|....:|   .:::.|:.:.:....|          ..|.|.|.|    :|.....|.|| 
Human   292 GGGDTVDSSIF---RKLRSSKPEGEAGRSP----------GEADEGRSPPEASRPWVCQKSFAHF 343

  Fly   200 PHNGGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSAS--------------GCQ 250
            .....|......|..|.|::...::|...||.|:..|...|:...:.|              .|:
Human   344 DVQSMLFDLNEAAANRVSVSQRRNTTTGASAASAASAMASLTASRAHSLGGLDPAFTSTEDLNCK 408

  Fly   251 --------------LLSNGHHYQ-------------SQSSVSS------------------NSSI 270
                          ||.:..|::             |::||.|                  |:||
Human   409 ENLEQDLGDDNSNDLLLSCPHFRNEIGGECERNVSFSRASVGSPSSGEGHLAEPALSAYRTNASI 473

  Fly   271 -VSAIPASQRLLEEALAKPAPYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTTWMAKFETDD 334
             |..:|..|   :...::|..|.:              ||                      .|.
Human   474 SVLEVPKEQ---QRTQSRPRQYSI--------------EH----------------------VDL 499

  Fly   335 TAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVA-NQEH-----MRILMRLRTGTMHELLPV 393
            .|:.|:.::..:||:|..|:||:|||:.:|||.|.:. ::||     .||:.|.|     ||:.:
Human   500 GARYYQDYFVGKEHANYFGVDEKLGPVAVSIKREKLEDHKEHGPQYQYRIIFRTR-----ELITL 559

  Fly   394 -SCLLPQPSPAKMAHTLNENI----TVEHFMP---ILC-------PKASQLISVYDEHVLVSHFK 443
             ..:|...:|....|.....:    .:|:.:|   |.|       ||.::.:...||..|....|
Human   560 RGSILEDATPTATKHGTGRGLPLKDALEYVIPELNIHCLRLALNTPKVTEQLLKLDEQGLCRKHK 624

  Fly   444 FGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVF 508
            .|:||.:.||::|||::.|::..|||:|||.::|:::.||....|...||::...||..::|.::
Human   625 VGILYCKAGQSSEEEMYNNEEAGPAFEEFLSLIGEKVCLKGFTKYAAQLDVKTDSTGTHSLYTMY 689

  Fly   509 KEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNT-PFSPDMIASHFLHAFIVVQPI 572
            ::.|||||||||||:|..:.|||.||||||||||.|:|||... ||:|..|.|||.|.||:|:..
Human   690 QDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPFTPKNIRSHFQHVFIIVRVH 754

  Fly   573 EPNTPHTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKFAKLEQR 637
            .|.|.:..|.::||...|.|.|||.:|:...|||...|::|:|.|:||||||.:|::||..:..|
Human   755 NPCTDNVCYSMAVTRSKDAPPFGPPIPSGTTFRKSDVFRDFLLAKVINAENAAHKSDKFHTMATR 819

  Fly   638 TRTSLLQNLCEELREKTR-DFLGTDLSQTSAGSPTPETPKAESGSGGNAGSRFIDTVKKALIMRV 701
            ||...|::|.|.....|. |..| ..:..|..|...|..||.:|:..::..        |:..||
Human   820 TRQEYLKDLAENCVSNTPIDSTG-KFNLISLTSKKKEKTKARAGAEQHSAG--------AIAWRV 875

  Fly   702 RSQSVDTG 709
            .:|....|
Human   876 VAQDYAQG 883

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RapGAP1NP_001097114.2 GoLoco 147..168 CDD:460481 2/20 (10%)
Rap_GAP 460..639 CDD:460463 84/179 (47%)
SIPA1L3NP_055888.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 45..166 13/64 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..332 17/105 (16%)
Rap_GAP 641..821 CDD:460463 84/179 (47%)
PDZ_SIPA1-like 966..1038 CDD:467227
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1046..1112
PHA03247 <1064..1490 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1124..1221
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1236..1565
SPAR_C 1477..1726 CDD:463383
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1583..1636
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1685..1712
Blue background indicates that the domain is not in the aligned region.

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