DRSC/TRiP Functional Genomics Resources

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Protein Alignment RapGAP1 and Tsc2

DIOPT Version :9

Sequence 1:NP_001097114.2 Gene:RapGAP1 / 34032 FlyBaseID:FBgn0264895 Length:959 Species:Drosophila melanogaster
Sequence 2:NP_001273649.1 Gene:Tsc2 / 22084 MGIID:102548 Length:1814 Species:Mus musculus


Alignment Length:727 Identity:160/727 - (22%)
Similarity:256/727 - (35%) Gaps:181/727 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 SSEISLAPSSAASSPKPLHRMIKYWRNSSGKIPGLRKSESFAEYR---RHSSNSATISGGSGGRS 79
            |.|..|:|.|:..:..||..:..          .|..:|.|.|:|   .:.|.|...:|.:...:
Mouse  1211 SLENPLSPFSSDINNMPLQELSN----------ALMAAERFKEHRDTALYKSLSVPAAGTAKPPT 1265

  Fly    80 STSSARQLQYQRLEMESCENIDMLTEPLRRQHAFMANTQKQQPAGGGSGSGSVTHSPERLRGATT 144
            ...|.....:..|...||:.      .|.|..::..:....:.  |..|...|...|..      
Mouse  1266 LPRSNTVASFSSLYQPSCQG------QLHRSVSWADSAMVLEE--GSPGETQVPVEPPE------ 1316

  Fly   145 ATQDLFELLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVPQPHSPHDSHAH-------PHN 202
                    ||..:.:...|:.|..|..:|    |.|:||.:.       ..||..       |..
Mouse  1317 --------LEDFEAALGTDRHCQRPDTYS----RSSSASSQE-------EKSHLEELAAGGIPIE 1362

  Fly   203 GGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQL----LSNGHHYQSQSS 263
            ..:...|:|..:  .::...|..:|.|  ||:|....|..::...|.::    ||.....:|||.
Mouse  1363 RAISSEGARPAV--DLSFQPSQPLSKS--SSSPELQTLQDILGDLGDKIDIGRLSPEAKVRSQSG 1423

  Fly   264 V-SSNSSIVSAIPASQRLL---EEALAKPAP-YPMILLPLHGGYWMDGTEHECGYDARGNPLLPQ 323
            : ...::..||.....|:.   |..|...:| .|..|.|  .||    |..:.....||.     
Mouse  1424 ILDGEAATWSATGEESRITVPPEGPLPSSSPRSPSGLRP--RGY----TISDSAPSRRGK----- 1477

  Fly   324 TTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVANQEHMRILMRLRTGTMH 388
                 :.|.|:    ::...||.....:.|::...  :.|.:........|..:           
Mouse  1478 -----RVERDN----FKSRAAASSAEKVPGINPSF--VFLQLYHSPFFGDESNK----------- 1520

  Fly   389 ELLPVSCLLPQPSPAKMAHTLNENITVEHFMPILCPKASQLISVYDEHVLVSHFKFGVLYQRYGQ 453
               |:  |||..|..:....|::                  |..||.|      |..|||...||
Mouse  1521 ---PI--LLPNESFERSVQLLDQ------------------IPSYDTH------KIAVLYVGEGQ 1556

  Fly   454 TTEE-ELFGNQQTSPAFDEFLDVLGQRIRLKD---HKGYRGGLDIQNGHTGDTAVYEVFKEREIM 514
            ::.| .:..|:..|..:.|||..||:.|.|||   .|.|.||||:    .|:...:......:||
Mouse  1557 SSSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDV----CGEDGQFTYCWHDDIM 1617

  Fly   515 ---FHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQPIEPNT 576
               ||::||:|..:.|..:..:|||:|||.|:|::.::...|....|...|....:::.|::   
Mouse  1618 QAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIIYNDSGEDFKLGTIKGQFNFVHVIITPLD--- 1679

  Fly   577 PHTRYK---VSVTARDDVPFFGPTL-------PNPAVFRKGQEFKEFILTKLI------------ 619
                ||   :::..|.|    ||..       |...|........|..:|.|:            
Mouse  1680 ----YKCNLLTLQCRKD----GPACKCEWWRQPGEIVVWALPVVMELTVTILLCHLQMASQVHHS 1736

  Fly   620 -NAENACYKAEKFAKLEQRTRTSLLQNLCEELREKTRDF-LGTDLSQTSAGSPTPE-TPKAESGS 681
             :.....|.::..|:|....|  |.|.:.||:....... |....:.|.|.:..|| ||..|:|.
Mouse  1737 RSNPTDIYPSKWIARLRHIKR--LRQRIREEVHYSNPSLPLMHPPAHTKAPAQAPEATPTYETGQ 1799

  Fly   682 GGNAGSRFIDTV 693
                ..|.|.:|
Mouse  1800 ----RKRLISSV 1807

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RapGAP1NP_001097114.2 GoLoco 147..168 CDD:280368 4/20 (20%)
Rap_GAP 460..639 CDD:280332 52/207 (25%)
Tsc2NP_001273649.1 DUF3384 54..466 CDD:288697
Tuberin 555..903 CDD:281532
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1078..1174
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1326..1357 10/41 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1429..1491 17/81 (21%)
Rap_GAP 1564..1756 CDD:280332 52/206 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1772..1798 8/25 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1559
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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