DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RapGAP1 and Sipa1l1

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	XP_006515747.1	Gene:	Sipa1l1 / 217692	MGIID:	2443679	Length:	1796	Species:	Mus musculus

Alignment Length:	826	Identity:	234/826 - (28%)
Similarity:	332/826 - (40%)	Gaps:	231/826 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSYRTLVDHGHPIIVGSSEIS------------------------------LAPSSAASSPKPLH 36
            |...:|...|.|:..||| :|                              |.|.:..|||:...
Mouse   104 SCLESLSSKGSPVSQGSS-VSLNSNDSAMLKSIQNTLKNKTGPAESMDSRFLMPEAYPSSPRKAL 167

  Fly    37 RMIKYWRNSSGKIPGLRKSESFAE------------YRRHSSNSATISGGSGGRSSTSSARQLQY 89
            |.|:...||...|..| ..:||.|            :|.:.|.|:....|:.|.|.        :
Mouse   168 RRIRQRSNSDITISEL-DVDSFDECISPTYKSGPSLHREYGSTSSIDKQGTSGDSF--------F 223

  Fly    90 QRLEMESCENIDMLTEPLRRQHAFMANTQKQQPAGGGSGSG---SVTHSP----ERLR------- 140
            ..|:....:..|....|.:.....:        .|||.|||   .|...|    |.||
Mouse   224 DLLKGYKDDRSDRGPTPTKLSDFLI--------TGGGKGSGFSLDVIDGPISQRENLRLFKEREK 280

  Fly   141 ------GATTATQDLFELL------ERVQCSRLDDQRC-------VLPAYFS------------- 173
                  .:.|....:|..|      |..:.|.|:|.|.       ..|..|:
Mouse   281 PLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNE 345

  Fly   174 --QNHHR---------GSNAS--EERVPQPHSPHDSHAHPHNGGLQHSGSRATLRHSMNHSSS-- 223
              .|.|.         |::|:  ...|..|.|...|.:.| .|..:...|:.:|........|
Mouse   346 AIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSP-MGSTEDLNSKGSLGMDQGDDKSNE 409

  Fly   224 ---------STVSGSACSSTPASPQLSGVVSASGCQLLSNGHHYQSQ-SSVSSNSSI-VSAIPAS 277
                     :.:.|........|...||  |.|||:..|    ::|. ||..:|:.: |..:|..
Mouse   410 LVMSCPYFRNEIGGEGERKISLSKSNSG--SFSGCESTS----FESALSSHCTNAGVAVLEVPKE 468

  Fly   278 QRLLEEALAKPAPYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTTWMAKFETDDTAKCYRRF 342
            ..:|.  |.:...|.:              ||                      .|..|..||:|
Mouse   469 SLMLH--LDRVKRYTV--------------EH----------------------VDLGAYYYRKF 495

  Fly   343 YAAREHSNLIGLDEQLGPILLSIKTENVANQE------HMRI------LMRLRTGTMHELLPVSC 395
            :..:||.|..|.||.|||:.:||:.|...:.:      :.||      ||.||...:.:.:
Mouse   496 FYQKEHWNYFGADENLGPVAVSIRREKPEDMKENGSPYNYRIIFRTSELMTLRGSVLEDAI---- 556

  Fly   396 LLPQPSPAK--MAHTLNENITVEHFMP---ILC-------PKASQLISVYDEHVLVSHFKFGVLY 448
                ||.||  .|..|.....:||.:|   :.|       ||.::.:...||..|....|.|::|
Mouse   557 ----PSTAKHSTARGLPLKEVLEHVIPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMY 617

  Fly   449 QRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREI 513
            .:.||:||||::.|:...|||:|||.:||:|:|||..:.||..||.:...||..::|..:|:.||
Mouse   618 CKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEI 682

  Fly   514 MFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNT-PFSPDMIASHFLHAFIVVQPIEPNTP 577
            ||||||:||:|..:.|||.||||||||||.|||||... ||||..|.|||.|.|::|:...|.|.
Mouse   683 MFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRAHNPCTE 747

  Fly   578 HTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSL 642
            ...|.|:||...|||.|||.:|....|.|...|::|:|.|:||||||.:|:|||..:..|||...
Mouse   748 SVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEY 812

  Fly   643 LQNLCE---------------------ELREKTRDFLGTDLSQTSA 667
            |::|.|                     :.:||::.:.|.:||...|
Mouse   813 LKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGA 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	7/33 (21%)
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	91/179 (51%)
Sipa1l1	XP_006515747.1	Rap_GAP	629..809	CDD:396632	91/179 (51%)
		PDZ_signaling	953..1023	CDD:238492
		SPAR_C	1496..1741	CDD:403176
		ZapB	1729..1784	CDD:399182
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841934
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740