DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RapGAP1 and Sipa1

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001157952.1	Gene:	Sipa1 / 20469	MGIID:	107576	Length:	1038	Species:	Mus musculus

Alignment Length:	690	Identity:	212/690 - (30%)
Similarity:	282/690 - (40%)	Gaps:	221/690 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 GGSGSGSVTHSPERLRG-ATTATQDLFELLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVP 188
            ||.|      ||.  || |...|.|||                               |.:.|.|
Mouse     4 GGVG------SPR--RGMAPAPTDDLF-------------------------------ARKLRQP 29

  Fly   189 --QPHSPHDSHAHPHNGGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQL 251
              .|.:||.....|..|.|..|||.|               |.....|||||:
Mouse    30 ARPPLTPHTFEPRPARGPLLRSGSDA---------------GEVRPPTPASPR------------ 67

  Fly   252 LSNGHHYQSQSSVSSNSSIVSAIPASQRLLEEALA-------KPAP-YPMILLP----------- 297
             :..|.::       ::|..:|.|.  ||..:.||       :|.| :|.:|.|
Mouse    68 -ARAHSHE-------DASRPAATPT--RLFTDPLALLGLPAEEPEPTFPPVLEPRWFAHYDVQSL 122

  Fly   298 --------------------------------LHG--GYWMD-GTEHECGYDARGNPLLP----- 322
                                            |.|  |:..: |.|.|.|.   |.|:.|
Mouse   123 LFDWAPRPRGTGSHIEANSGTLAEGQTTTSDLLLGAPGFVSELGGEGELGL---GGPISPPVPPA 184

  Fly   323 --------------QTTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVANQ 373
                          :||..:....|..|..||:::..:||.|..||||.|||:.:|::.|.....
Mouse   185 LPNAAVSVLEEPQTRTTAYSLEHADLGAGYYRKYFYGKEHQNFFGLDEALGPVAVSLRREEKEGS 249

  Fly   374 -----EHMRILMR---LRT--GTMHELLPVSCLLPQP----SPAKMAHTLNENITVEHFMPIL-- 422
                 ...|:::|   |||  ||:.|    ..|.|.|    ||.|:         :||..|.|
Mouse   250 GGGTLHSYRVIVRTTQLRTLRGTISE----DALPPGPPRGLSPRKL---------LEHVAPRLSP 301

  Fly   423 -C-------PKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQR 479
             |       ||..:.:...||.||....|.|:||.|.||.:|||::.||:...||.:||.:||..
Mouse   302 TCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGAAFMQFLTLLGDV 366

  Fly   480 IRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAI 544
            :|||..:.||..||.:...||..::|..:::.||||||||:||:|..:.|||.||||||||||.|
Mouse   367 VRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTI 431

  Fly   545 VFQETNT-PFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLP-NPAVFRKG 607
            ||||..: ||.|..|.|||.|.|:||:...|.||||.|:|:|:...|.|.|||.|| ....|...
Mouse   432 VFQEPGSKPFCPTTIRSHFQHVFLVVRAHAPCTPHTSYRVAVSRTQDTPAFGPALPEGGGPFAAN 496

  Fly   608 QEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSA-GSP- 670
            .:|:.|:|.|.:|.|.|...|.:|..:..|||...||:|.      |.:...|.|...|. |.|
Mouse   497 ADFRAFLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLA------TNEVTTTSLDSASRFGLPS 555

  Fly   671 -------TPETPKAESGSGGNAGSRFIDTVKKALIMRVRS 703
                   ||.:|.||..:.|            ||:..||:
Mouse   556 LGGRRRATPRSPGAELQAAG------------ALMWGVRA 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	3/20 (15%)
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	84/180 (47%)
Sipa1	NP_001157952.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..85		35/156 (22%)
		PHA03378	<29..>112	CDD:223065	29/119 (24%)
		Rap_GAP	347..528	CDD:396632	84/180 (47%)
		PDZ	683..755	CDD:395476
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	831..850
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	856..899
		Smc	<901..>1023	CDD:224117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..970
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841931
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740