Protein Alignment RapGAP1 and sipa-1

DIOPT Version :10

• Sequence 1: NP_001097114.2
• Gene: RapGAP1 / 34032
• FlyBaseID: FBgn0264895
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: NP_001256347.1
• Gene: sipa-1 / 179596
• WormBaseID: WBGene00012100
• Length: 997
• Species: Caenorhabditis elegans
• Alignment Length: 685
• Identity: 199/685 - (29%)
• Similarity: 289/685 - (42%)
• Gaps: 163/685 - (23%)

  Fly    79 SSTSSARQLQYQRLEMESCENIDMLTEPLRRQHAFMANTQKQQPAGGGS---GSGSVTHSPERLR 140
            |:|||.|          |......|...|..|...::.:....|..|||   ||.:.|.|
 Worm     3 STTSSVR----------SANRTRSLCHHLHHQPLLVSGSSTGSPPIGGSMDEGSSASTSS----- 52

  Fly   141 GATTATQDLFELLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVPQPHSPHDSHAHPHNGGL 205
            .||....|:|        :|......|:.|        |:.|::...|....|:.|..
 Worm    53 SATARALDMF--------NRRGSVLAVVIA--------GNTAADVLPPSAGVPNTSAV------- 94

  Fly   206 QHSGSRATLRHSMNHSSSSTVSGSACSST-------------PASPQLS------GVVSASGCQL 251
                          .|||..:|....|||             |..|:||      .:.:|.|..:
 Worm    95 --------------SSSSGVISADQPSSTNSDNDTETFNEWRPPFPRLSAYQDCLSLAAAWGLGM 145

  Fly   252 LSNGHHYQSQSSVSSNSSIVSAIPASQRLLEEALAK-PA--------PYPMILLPLHGGYWMDGT 307
            ..||  ...:.:.:|.:...|...:......|.||. ||        |.....|..|........
 Worm   146 HPNG--LDDKPTGASQAQSPSEDDSGDGKFNELLASCPAFRNELGWEPTRRFALSRHTFDMAHTD 208

  Fly   308 EHECGYDARGNPLLPQTTWMAKFETDDTA-------------KC------------------YRR 341
            .|||            .|||.:....:..             .|                  ||.
 Worm   209 AHEC------------ETWMREHSASEAGILEDVSNVYLGGRLCAARQPKTVIEPQDIGSYYYRH 261

  Fly   342 FYAAREHSNLIGLDEQLGPILLSIKTENVANQEH---MRILMRLR-TGTMHELLPVSCL-LPQPS 401
            .:.::.|...:|:|:.||||.:|:..|.|..:|.   .|:::|:. ..|:...:|...| .|:.|
 Worm   262 CFISKNHIEYLGMDDILGPISISMVREIVDRKESYSIYRMIVRISDQKTIRVAVPEEALSTPEGS 326

  Fly   402 PAKMAHTLNENITVEHFMPILCPKAS--------------QLISVYDEHVLVSHFKFGVLYQRYG 452
            .......:.|      .:.|:|||.|              :||...||..:.:.:|.|::..:..
 Worm   327 DRATRPLMRE------LLEIVCPKISFGILRPSIQSPRVEELIMKIDEQPIYTRYKVGIMLCKNE 385

  Fly   453 QTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHV 517
            |:|||:::.|:.::|:||||||.||||:.||..:.|:||||.:...||..::|..::..||||||
 Worm   386 QSTEEQMYNNEFSTPSFDEFLDFLGQRVTLKGFEAYKGGLDTRGDTTGTHSIYSEYQAHEIMFHV 450

  Fly   518 STLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNT-PFSPDMIASHFLHAFIVVQPIEPNTPHTRY 581
            |||||.|..:.|||.||||||||:|.|||||... ||||..:.|||.|.||:|:.....:.:..|
 Worm   451 STLLPFTPSNRQQLSRKRHIGNDMVTIVFQEPGALPFSPITVRSHFQHVFIIVRVHNECSENVTY 515

  Fly   582 KVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNL 646
            .|:|:...|||.|||.:|..|.|.|..||.:::|||:||||||.::::|||.:..|||...|::|
 Worm   516 SVAVSRSKDVPAFGPPVPKGACFSKCAEFHDWLLTKIINAENAVHRSKKFATMAARTRREALRDL 580

  Fly   647 CE--------ELREKTRD-FLGTDLSQTSAGSPTP 672
            .|        |...|... |||..:.:....:|.|
 Worm   581 VENYVGPHQNEGASKIASRFLGGSVKRKERHNPKP 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:460481	3/20 (15%)
		Rap_GAP	460..639	CDD:460463	90/179 (50%)
sipa-1	NP_001256347.1	Rap_GAP	393..573	CDD:460463	90/179 (50%)
		PDZ_SIPA1-like	721..794	CDD:467227
		COG2433	<915..>996	CDD:441980