Protein Alignment RapGAP1 and F53A10.2

DIOPT Version :9

• Sequence 1: NP_001097114.2
• Gene: RapGAP1 / 34032
• FlyBaseID: FBgn0264895
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: NP_001022190.1
• Gene: F53A10.2 / 173502
• WormBaseID: WBGene00018734
• Length: 811
• Species: Caenorhabditis elegans
• Alignment Length: 916
• Identity: 326/916 - (35%)
• Similarity: 470/916 - (51%)
• Gaps: 192/916 - (20%)

  Fly    63 RHSSNSATI--SGGSGGRSSTSSARQLQYQRLEMESCENIDMLTEPLRRQHAFMANTQKQQPAGG 125
            ||:::...:  :|.:...|||:|         |.:.|.:...|..  ||......|.:.:.....
 Worm    32 RHATSQYNLRSTGSTSSDSSTAS---------ENDKCSDFSSLKS--RRASCIELNKEDEFKVMA 85

  Fly   126 GS----GSGSVTH--SPERLRGATTATQDLFELLERVQCSRLDDQRCVLPAYFSQNHH------- 177
            ..    ...::.|  |.:.:|..||:|:.|..:::                  |...|
 Worm    86 ADKLLMAMENMKHATSSQAIRWRTTSTESLPGIIK------------------SNRRHSKGPLEL 132

  Fly   178 -RGSNASEERVPQPHSPHDSHAHPHNGGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLS 241
             :|..|.:..|.:|       |...|.|:.   ...||       .|||||....|....:|
 Worm   133 IQGLMAKKAAVGRP-------AKFKNLGVV---GPPTL-------ISSTVSLHEISGFTHNP--- 177

  Fly   242 GVVSASGCQLLSNGHHYQSQSSVSSNSSIVSAIPASQRLLEEALAKPAPYPMILLPLHGGYWMDG 306
                       ::||..:.....::.|::.:.:  ::.::.|.|.|..|||.|:|| ..|:||||
 Worm   178 -----------TSGHQNEQTHQKTNGSAVHNQL--TRNIMNEVLTKVGPYPQIVLP-SNGFWMDG 228

  Fly   307 TEHECGYDARGNPLLPQTTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVA 371
            ...:...|.:.|.:...:....|.|||:|:.||||.:..|||.:....|..:||::||::||.::
 Worm   229 VNQQHHMDDQVNNMNVNSCARFKLETDETSHCYRRHFFGREHHDFFANDPIVGPLVLSVRTEVIS 293

  Fly   372 NQEHMRILMRLRTGTMHELLPVSCLLPQPSPAKMAHTLNENITVEHFMPILCPKASQLISVYDEH 436
            :.:|.||::|.|.||:||::..:.|..:||.::||..|.|.||.|.|.|:..|..|:||..||||
 Worm   294 SCDHFRIILRTRKGTIHEIVSATALADRPSASRMAKLLCEEITTEQFSPVAFPGGSELIVQYDEH 358

  Fly   437 VLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGD 501
            ||.:.:||||:||:.||||||:||||...||||||||.::|..::|...:.||||||..:..||.
 Worm   359 VLTNTYKFGVIYQKGGQTTEEQLFGNPHGSPAFDEFLSMIGDSVQLNGFQKYRGGLDTAHNQTGH 423

  Fly   502 TAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDMIASHFLHAF 566
            .:|:..||.|||||||||:||:|.||.||||||||||||||||:|||.||||:||||||:||||:
 Worm   424 QSVFSEFKNREIMFHVSTMLPYTIGDAQQLQRKRHIGNDIVAIIFQEANTPFAPDMIASNFLHAY 488

  Fly   567 IVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKF 631
            :|||||:..|...||:|||.|||||||||||||.|::|::||:|:.|:||||||||||.||:.||
 Worm   489 VVVQPIDALTDRVRYRVSVAARDDVPFFGPTLPTPSIFKRGQDFRNFLLTKLINAENAAYKSSKF 553

  Fly   632 AKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSAGSPTPETPKAESGSGGNAGSRFIDTVKKA 696
            |||.:|||:|||..|...|||:...:....|..||:|.   |:....|.|..:.|...:.:||||
 Worm   554 AKLAERTRSSLLDGLHATLRERAEFYATPLLESTSSGG---ESAATTSSSSNSYGGGILSSVKKA 615

  Fly   697 LIMRVRSQSVDTGNGHGPGQTDKFSVNTKLGTLNSKKETHPEMQTPNLNTCSRTASKSSSKSKSS 761
            .|.|.||.                          |::.:|...:...:|..|| ..||.|.:.||
 Worm   616 FIGRSRSV--------------------------SQEASHVPHRAATINVTSR-PKKSISSTSSS 653

  Fly   762 NESTSSSP--------------DITSRQANNNNTNSIGGHLPQNGTGGGVVAAAVSAAQNGVVAV 812
            ..:.:.||              :|:|:::.:|.
 Worm   654 TSARTHSPIRDEEVVKPYRKEWEISSQESPDNE-------------------------------- 686

  Fly   813 ATMSETSDDSSLNSVDLDPMMAHLDGGATYIDSDTGLESMSSAEAT--TKA--CSLCLDGVQSTI 873
                                  |        |||||:|||||.|.:  |:|  |:.|:|...
 Worm   687 ----------------------H--------DSDTGMESMSSTEMSGQTRASSCTFCVDDFH--- 718

  Fly   874 MGSSPSNETIVKIENLRQEVTRLKCDKLDLLRQNVTCQRDIKRLRERELSLQGDLSAAGREILRL 938
            :.::..:....::|.|..:||||:.:|.|||||||:|:.|||:|::|:..|..:|..|..||.||
 Worm   719 VAANHQSSDAKRLETLCVDVTRLQNEKHDLLRQNVSCKTDIKKLKDRQSVLSEELERANDEISRL 783

  Fly   939 RDLLKE 944
            |.:||:
 Worm   784 RRMLKK 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	1/20 (5%)
		Rap_GAP	460..639	CDD:280332	119/178 (67%)
F53A10.2	NP_001022190.1	Rap_GAP	382..561	CDD:366939	119/178 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166845
Domainoid	1	1.000	259	1.000	Domainoid score	I1075
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	488	1.000	Inparanoid score	I783
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28778
OrthoDB	1	1.010	-	-		D163377at33208
OrthoFinder	1	1.000	-	-		FOG0002359
OrthoInspector	1	1.000	-	-		oto19717
orthoMCL	1	0.900	-	-		OOG6_105084
Panther	1	1.100	-	-	LDO	PTHR15711
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1559
SonicParanoid	1	1.000	-	-		X1790
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.940