Protein Alignment RapGAP1 and RapGAP1

DIOPT Version :10

• Sequence 1: NP_001097114.2
• Gene: RapGAP1 / 34032
• FlyBaseID: FBgn0264895
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: XP_061513880.1
• Gene: RapGAP1 / 1271375
• VectorBaseID: AGAMI1_003379
• Length: 1039
• Species: Anopheles gambiae
• Alignment Length: 1075
• Identity: 596/1075 - (55%)
• Similarity: 699/1075 - (65%)
• Gaps: 205/1075 - (19%)

  Fly    11 GHPIIVGSSEISLAPSSAASSPKPLHRMIKYWRNSSGKIPGLRKSESFAEYRRHSSNSATISGGS 75
            |.|:..|||.    |.||..||                               .:|..::.|||:
Mosquito    39 GGPLADGSSR----PGSANLSP-------------------------------IASKGSSTSGGA 68

  Fly    76 GGRSSTSSARQLQYQRLEMESCENIDMLTEPLRRQH----AFMANTQKQQPAGGGS---GSGSVT 133
            |....|.|.              |......|..|||    ...|...||.....|:   .|.|.|
Mosquito    69 GADDETRSL--------------NRSSRLSPQGRQHMGGWTTAAANAKQNGLSAGTTAPSSKSAT 119

  Fly   134 HSPERLRGATTATQDLFELLERVQCSRLDDQRCVLPAYFSQ-------NHHR----GSNASEERV 187
            .||:||||   ||.||||||||||||||||||||||:||:|       ...|    .:.::|||:
Mosquito   120 TSPDRLRG---ATHDLFELLERVQCSRLDDQRCVLPSYFTQVRTVSTGTKTRMVCINTRSAEERI 181

  Fly   188 PQPHSPHDSHAH-----PHNGGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSAS 247
            ..|||.::|..:     |.:.|.....:|:.|||| |..||:..|.|  :||||||.|  :.::|
Mosquito   182 ANPHSTNESTNNLSVQIPQSMGGGGGNTRSLLRHS-NSMSSNPHSNS--NSTPASPHL--LSNSS 241

  Fly   248 GCQLLSNG-------HH------YQSQSSVSS-NSSIVSAIPASQRLLEEALAKPAPYPMILLPL 298
            ...|...|       ||      ||||||||| :|||:|.:|..|||||:||:||.|:|||::|.
Mosquito   242 SVHLHHAGAGGGGLHHHQQQHPQYQSQSSVSSQSSSIISTVPPVQRLLEDALSKPGPHPMIIVPN 306

  Fly   299 HGGYWMDGTEHECGYDARGNPLLPQTTW-MAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPIL 362
            .||||:|||:|:..|:...:     ||| :.|.|:||||||||||:.|||||||:|.|:||||:|
Mosquito   307 SGGYWVDGTDHDASYEVPSH-----TTWRVGKIESDDTAKCYRRFFIAREHSNLVGHDDQLGPVL 366

  Fly   363 LSIKTENVANQEHMRILMRLRTGTMHELLPVSCLLPQPSPAKMAHTLNENITVEHFMPILCPKAS 427
            ||||:||||||||:|||:||||||||||:|.|||...|||.|||..|||.|.|:.|||:||||||
Mosquito   367 LSIKSENVANQEHIRILLRLRTGTMHELIPASCLGSSPSPIKMARLLNEQINVDSFMPVLCPKAS 431

  Fly   428 QLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGL 492
            .||:.|||||||::|||||||||:|||.|||||.|.:|:||||||||||||||||:|||||||||
Mosquito   432 ALIASYDEHVLVTNFKFGVLYQRFGQTAEEELFCNSETTPAFDEFLDVLGQRIRLRDHKGYRGGL 496

  Fly   493 DIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDM 557
            |||||||||||||:||||||||||||||||:||.||||||||||||||||||||||.||||||.|
Mosquito   497 DIQNGHTGDTAVYDVFKEREIMFHVSTLLPYTEADPQQLQRKRHIGNDIVAIVFQEENTPFSPAM 561

  Fly   558 IASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAE 622
            ||||||||||||||||||||:.|||:||||||||||||||||.|:||::|.|.|||:||||||||
Mosquito   562 IASHFLHAFIVVQPIEPNTPNCRYKISVTARDDVPFFGPTLPQPSVFKRGPELKEFLLTKLINAE 626

  Fly   623 NACYKAEKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSAG---SPTPETPKAESGSGGN 684
            ||||||:|||:||.|||:||||||.:||:||||||||.|:...:||   ||||||||:|   ||.
Mosquito   627 NACYKADKFAQLELRTRSSLLQNLVDELKEKTRDFLGMDVGGGAAGVPTSPTPETPKSE---GGF 688

  Fly   685 AGSRFIDTVKKALIMRVRSQSVD-TGNGHGPGQTDKFSVNTKLGTLNSKKETHPEMQTPNLNT-- 746
            .||||||||||||..|:|||:.| |.||.|...    ||:|..|...:|.  |..|:.....|
Mosquito   689 TGSRFIDTVKKALNARLRSQNSDPTNNGSGGAG----SVDTATGGGGAKH--HNSMKKSKDGTSL 747

  Fly   747 -----C--------SRTASKSSS--KSKSSNESTSSSPDITSRQA-------NNNNT------NS 783
                 |        .|:.||||:  ..||.|:|.:||||||||.:       ||||:      |:
Mosquito   748 VSDMPCGPGGAVNIGRSLSKSSTTGSRKSPNDSVASSPDITSRCSLNPTLTNNNNNSNAPNNNNT 812

  Fly   784 IGGHLPQ---NGTG-GGVVAAAVSAAQNGVVAVATMSETSDDSSLNSVDLDPM--MAHLDGGATY 842
            ||.:.|.   ||.| ||..||..:...||.||   ||||||||||||||||||  :..:|.||||
Mosquito   813 IGKNHPNGSANGNGAGGNAAAGGANNNNGPVA---MSETSDDSSLNSVDLDPMVFLPTVDAGATY 874

  Fly   843 IDSDTGLESMSSAEATTKACSLCLDGVQST----------------------------------- 872
            |||||||||||||:||||||||||||..||
Mosquito   875 IDSDTGLESMSSADATTKACSLCLDGTGSTNGGGSVVSVSISGASVTIDGGNARELRNSGGSASS 939

  Fly   873 ---------------IMG---SSPSNETIVKIENLRQEVTRLKCDKLDLLRQNVTCQRDIKRLRE 919
                           ::|   :|.:.||:.::|.:|||:||||||||||||||||||||||||||
Mosquito   940 GTGSTASAGQMGCGSVVGQGAASVTQETLQQVEGMRQEITRLKCDKLDLLRQNVTCQRDIKRLRE 1004

  Fly   920 RELSLQGDLSAAGREILRLRDLLKEYMPDTASAPL 954
            |||||||||:|||:|||||||||||.:|...:.|:
Mosquito  1005 RELSLQGDLAAAGKEILRLRDLLKECLPTAVADPI 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:460481	19/20 (95%)
		Rap_GAP	460..639	CDD:460463	155/178 (87%)
RapGAP1	XP_061513880.1	None