Protein Alignment RapGAP1 and Rap1gap

DIOPT Version :9

• Sequence 1: NP_001097114.2
• Gene: RapGAP1 / 34032
• FlyBaseID: FBgn0264895
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: XP_006538538.1
• Gene: Rap1gap / 110351
• MGIID: 109338
• Length: 755
• Species: Mus musculus
• Alignment Length: 760
• Identity: 282/760 - (37%)
• Similarity: 386/760 - (50%)
• Gaps: 196/760 - (25%)

  Fly   148 DLFELLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVPQPHSPHDSHAHPHNGGLQHSGSRA 212
            ||||::|::|.||:|:|||..|...        ...|:.:|.| |.|
Mouse    61 DLFEMIEKMQGSRMDEQRCSFPPPL--------KTEEDYIPYP-SVH------------------ 98

  Fly   213 TLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQLLSNGHHYQSQSSVSSNSSIVSAIPAS 277
                                                                             
Mouse    99 ----------------------------------------------------------------- 98

  Fly   278 QRLLEEALAKPAPYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTTWMAKFETDDTAKCYRRF 342
                 |.|.:..|:|:||||..||||::||.||........||...|| ..|.|.:.||:.||:.
Mouse    99 -----EVLGREGPFPLILLPQFGGYWIEGTNHEISSLPETEPLQSPTT-KVKLECNPTARIYRKH 157

  Fly   343 YAAREHSNLIGLDEQLGPILLSIKTENVANQEHMRILMRLRTGTMHELLPVSCLLPQPSPAKMAH 407
            :..:||.|...||..||.::.|:|.:.:.:|||:|:|:|.:..|.|:::|:|||...|:..:||.
Mouse   158 FLGKEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTHHDVIPISCLTEFPNVVQMAK 222

  Fly   408 TLNENITVEHFMPILCPKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEF 472
            .:.|::.|:.|.|:|.||||:||..:||||:.::|||||:||:.|||:|||||...:.||||.||
Mouse   223 LVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEF 287

  Fly   473 LDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHI 537
            |:.|||:::|:|.||:|||||:.:|.||..:||..|:.:||||||||.||:||||.|||||||||
Mouse   288 LEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHI 352

  Fly   538 GNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPA 602
            ||||||:|||:.||||.||||||:||||::|||..........||||||||||||||||.||:||
Mouse   353 GNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPA 417

  Fly   603 VFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEEL----------------- 650
            |||||.||:||:||||||||.||||||||||||:|||.:||:.|.|||
Mouse   418 VFRKGPEFQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDDDKM 482

  Fly   651 -------------------REKTRDFLG------TDLSQTSAGSPTPETPKAESGSG------GN 684
                               |.::.|.:|      ..:|.:.:||.||..|.....:|      |.
Mouse   483 ENGSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLLIPGK 547

  Fly   685 AGSRF--------IDTVKKALIMRVRSQSVDTGNGHGPGQTDKFSVNTKLGTLNSKKETHPEMQ- 740
            :.|||        |..|:::||:..:|.:.......|..::....:. .:..:..|:|:.|..|
Mouse   548 SASRFGRRGSALGIGAVEESLIVPGKSPTRKKSGPFGSRRSSAIGIE-NIQEVQEKRESPPAGQK 611

  Fly   741 TPNLNTCSRTASKSSSKSKSSNESTSSSPDITSRQANNNNTNSIGGHLPQNGTGGGVVAAAVSAA 805
            ||:       :...|.:.||.|.||.|||::.:.:      |.:                 .|||
Mouse   612 TPD-------SGHVSQEPKSENSSTQSSPEMPTTK------NRV-----------------ESAA 646

  Fly   806 QNGVVAVATMSETSDDSSLNSVDLDPMMAHLDGGATYID-SDTGL 849
            |...|.......:|..||..||     :...:|    :| .||||
Mouse   647 QRTEVLQGFSRSSSSASSFTSV-----VEETEG----VDGDDTGL 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	12/19 (63%)
		Rap_GAP	460..639	CDD:280332	125/178 (70%)
Rap1gap	XP_006538538.1	GoLoco	61..81	CDD:366965	12/19 (63%)
		Rap_GAP	275..454	CDD:366939	125/178 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841936
Domainoid	1	1.000	262	1.000	Domainoid score	I1932
eggNOG	1	0.900	-	-		E1_KOG3686
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	461	1.000	Inparanoid score	I1551
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163377at33208
OrthoFinder	1	1.000	-	-		FOG0002359
OrthoInspector	1	1.000	-	-		otm42989
orthoMCL	1	0.900	-	-		OOG6_105084
Panther	1	1.100	-	-	LDO	PTHR15711
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1559
SonicParanoid	1	1.000	-	-		X1790
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790