DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RapGAP1 and rap1gap2

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	XP_017946981.1	Gene:	rap1gap2 / 100495015	XenbaseID:	XB-GENE-6050621	Length:	734	Species:	Xenopus tropicalis

Alignment Length:	751	Identity:	295/751 - (39%)
Similarity:	409/751 - (54%)	Gaps:	101/751 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 GLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSG---VVSASGCQLLSNGH--HYQSQSS 263
            ||.|. ||...|.......|:| |.......||||..:.   :.||...::|....  ..:.|.|
Frog    23 GLLHK-SRKQNRERRKQELSNT-SEVTLPERPASPPATAPPTMKSAEFFEMLEKMQVPKLEEQKS 85

  Fly   264 VSSNSSIVSAIPASQRLLEEALAKPAPYPMILLPLHGGYWMDGTEHE----------CGYDARGN 318
             .|..:....||...  :||.|.|..|||:|:||..||||::..|:.          |  |....
Frog    86 -GSQKNKEDYIPYPS--IEEILEKDMPYPLIILPQFGGYWIEDPENVSTPTSSDSSIC--DDEEE 145

  Fly   319 PLLPQTTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVANQEHMRILMRLR 383
            |:.| :|:..|.|...:|:.||:.:..::|.|.......||.::||:|.|.....|::||::|.:
Frog   146 PISP-STYGYKLEYKGSARAYRKHFMGKDHLNFYCTASSLGNLILSVKCEESDGIEYLRIILRSK 209

  Fly   384 TGTMHELLPVSCLLPQPSPAKMAHTLNENITVEHFMPILCPKASQLISVYDEHVLVSHFKFGVLY 448
            ..|:||.:|:|.....||..::|..|.::.|...|.|:|.|||||||..||||.:.:.|||||:|
Frog   210 AKTLHERIPLSGFSKLPSIPQIAKALCDDATGLKFNPVLYPKASQLIVAYDEHEINNTFKFGVIY 274

  Fly   449 QRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREI 513
            |:|.||:|||||||.:.||||.||:|:||..:.|:|.||:|||||:.:|.||..::|.||:|:||
Frog   275 QKYKQTSEEELFGNSEESPAFKEFMDLLGDAVLLQDFKGFRGGLDVAHGQTGTESIYTVFREKEI 339

  Fly   514 MFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQPIEPNTPH 578
            ||||||.||.||||.||||||||||||||||:|||.||||.||||||:||||:||||...|....
Frog   340 MFHVSTKLPFTEGDTQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVVQVENPEADI 404

  Fly   579 TRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLL 643
            |.||||||||:|||.|||.||||.||.|..||:||:||||||||:||.|::||||||.|||.:||
Frog   405 TMYKVSVTAREDVPSFGPPLPNPPVFHKNSEFREFLLTKLINAEHACCKSDKFAKLEDRTRAALL 469

  Fly   644 QNLCEELREKTRDFLGTDLSQTSAGSPTPETPKAESGSGGNAGSRFIDTVKKALIMRVRSQSVDT 708
            .||.::|...|:..||..          ||..|.|:|:.|.    |:::.|:|:  ||||.|::|
Frog   470 DNLHDDLHVHTQAMLGLG----------PEEDKLENGAHGG----FLESFKRAI--RVRSHSMET 518

  Fly   709 GNG----HGPGQTDKFSVNTKLGTLNSKKE------THPEMQT---------------PNLNTCS 748
            ..|    |   |:...|.:...|.:::..|      :.|.:.|               |.|:|.|
Frog   519 MVGSQKKH---QSAGISGSLSGGIVHTSAEITKTTFSPPAVVTKTQSKSPIKRRSGLFPRLHTGS 580

  Fly   749 RTASKSSSKSKS---SNESTSSSP---DITSRQANNNNTNSIG-------GHLPQNGTGGGVVAA 800
            .|.:::.::|.|   ..:||.|:|   |:.|..::|.::..||       ..|.:||...   .:
Frog   581 ETQAETRTRSDSVTAPQKSTDSAPTTQDVKSETSSNPSSPEIGPNKERPFSKLKENGKSN---IS 642

  Fly   801 AVSAAQNGVVAVATMSETSDDSSLNSVDLDPMMAHLDGGATYIDSDTGLESMSSAEATTKACSLC 865
            ..|::.:...:.|..||..::  ..|:...||.|.......::.|.:  .|..:..|||
Frog   643 RSSSSTSSFSSTAGESEAMEE--YESMGSQPMTASPFKQEVFVYSPS--PSNENQAATT------ 697

  Fly   866 LDGVQSTIMGSSPSNETIVKIENLRQEVTRLKCDKL 901
                 ..||..||   |.:|..|..:...:.:.|||
Frog   698 -----PVIMSRSP---TDIKSRNSPRSNLKFRFDKL 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	124/178 (70%)
rap1gap2	XP_017946981.1	Rap_GAP	286..465	CDD:366939	124/178 (70%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	264	1.000	Domainoid score	I1884
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1713
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163377at33208
OrthoFinder	1	1.000	-	-		FOG0002359
OrthoInspector	1	1.000	-	-		oto103168
Panther	1	1.100	-	-	O	PTHR15711
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1790
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070