Protein Alignment RapGAP1 and sipa1

DIOPT Version :10

• Sequence 1: NP_001097114.2
• Gene: RapGAP1 / 34032
• FlyBaseID: FBgn0264895
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: XP_002935408.2
• Gene: sipa1 / 100490716
• XenbaseID: XB-GENE-6065317
• Length: 1044
• Species: Xenopus tropicalis
• Alignment Length: 893
• Identity: 230/893 - (25%)
• Similarity: 370/893 - (41%)
• Gaps: 205/893 - (22%)

  Fly   188 PQPHSPHDSHAHP----------HNGGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASP---- 238
            |...|||.:....          ||||          ..|::.|.|...|||..:|....|
 Frog    15 PTRSSPHKNTCETKLSSVTGTKRHNGG----------GRSLSESESEKGSGSPSASRFKDPFLLL 69

  Fly   239 QLSGVVSASGCQLL-----------------SNGHH--------------YQSQSSVSSNSSIVS 272
            .|:|:  :.|.|.|                 |..|:              |:::.:|.|.:|..|
 Frog    70 GLAGI--SQGPQALDAKEKLPDGGPFFHRPKSFAHYDVQSILFNPFLRGEYEARRNVKSGASAAS 132

  Fly   273 AIPASQRLLEEALAKP-----------------APYPMILLPLHGGYWMDG-------------- 306
            .|.........:|:.|                 .||   .....||..|:|
 Frog   133 QIKTCTSSPRRSLSSPEEPADNGDGKDNELLLSCPY---FRNEVGGENMEGQKDQSWGFSSAMAF 194

  Fly   307 -TEHEC---GYDARGNPL------LPQTTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPI 361
             |.|.|   |.:|..:.|      :..:::..::: |..|..||:::..:||.|..|:||:||.|
 Frog   195 STPHICPVRGPNAAVSVLEEARERMRDSSYFVEYQ-DLGALYYRKYFYGKEHQNFFGVDERLGAI 258

  Fly   362 LLSIKTENVANQEHMRILMRL--RTGTMHELLPVSCLLPQPSPAKMAHTLNENIT----VEHFMP 420
            .:|::.:.....:.::...|:  ||..:..|.  ..:|.:..|:.:.|..:..|:    :|:.:|
 Frog   259 AISLRRDEREGSQSIQYNYRIIFRTTELKTLR--GSILEEAFPSAIRHNSSRAISPKKLLEYIVP 321

  Fly   421 ---ILC-------PKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDV 475
               :.|       ||..:.:...||..|....|.|:||.|..|.:|||::.|:....||..||::
 Frog   322 EVNLQCLRLASSSPKVPETLLKLDEQGLSFQRKIGILYCRAEQGSEEEMYNNETAGQAFQNFLNL 386

  Fly   476 LGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGND 540
            ||:.:|||..:.||..||.:...||..::|..:::.||||||||:||:|..:.|||.||||||||
 Frog   387 LGEEVRLKGFEKYRAQLDNKTDSTGTHSLYTRYQDYEIMFHVSTMLPYTASNSQQLLRKRHIGND 451

  Fly   541 IVAIVFQETNT-PFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPAVF 604
            ||.|:|||... ||:|..|.|||.|.|:||:...|.|.||.|.|:|:...|.|||||.|| ||.|
 Frog   452 IVTIIFQEPGALPFTPKTIRSHFQHIFLVVRVHNPCTAHTTYSVAVSRSADTPFFGPALP-PANF 515

  Fly   605 RKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLC-EELREKTRD-------FLGTD 661
            ....|.::|:|:|.:|.|||..:..||..:..|||...|::|. :.:...|.|       .||..
 Frog   516 SNSPELRDFLLSKAVNGENAAERGGKFLAMATRTREEYLKDLARDHVTTATLDSCSSKLAILGLS 580

  Fly   662 LSQTSAGSPTPETPKAESGSGGNAGS--RFIDTVKK------ALIMRVRSQSVDTGNGHGPGQTD 718
            ..:..|||         :|:|..||.  |:..||..      ||:..||::|....:|     |.
 Frog   581 KKRDRAGS---------TGTGDKAGKSPRWAYTVPPEFHSPGALVWPVRAKSYSVPDG-----TY 631

  Fly   719 KFSVNTK-LGTLNSKKETHPEMQTPNLNTCSRTASKSSSKSKSSNE-------STSSSPDITSRQ 775
            ...:::: |..::.:||....:   :.:...|.....:..||...:       .....|...|..
 Frog   632 LLGISSEMLVLIDIQKEREIAI---SFHCSCRDVLGWTYSSKGGLDLYYGGAGRLELCPVAGSDA 693

  Fly   776 ANNNNTNSIGGHLPQNGTGGGVVAAAVSAAQNGVVAV-------ATMSETSDDSSLNSVDLDP-- 831
            ......|.|...|  ....||.....:...:||:..:       ..::|....|...:|.|.|
 Frog   694 EVEEEVNHIVKRL--QVVSGGCETREIPLLRNGLGQLGFKADSEGFVTEVERFSMAETVGLCPGA 756

  Fly   832 -----------MMAHLDGGATYID-----------SDTGLESMSSAEATTKACS-------LCLD 867
                       :::..|..:.|:.           .:.|....|.:|...::..       :.:|
 Frog   757 RLVAICGQPFCLLSPNDVRSLYLSGKKVTVTTLPPDEAGKPRRSFSELYVRSLQGQRVLKPIVVD 821

  Fly   868 GVQSTIMGSSPSNE--TIVKIENLRQEVTRLKCDKLDLLRQNVTCQRD 913
            ..:..:..:.||:|  |:::..::::|.|..:.:|.||...:|..|.|
 Frog   822 DKEKCLEKAKPSSEARTLLRTLSVQEERTEFRYNKSDLAPPDVIPQPD 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:460481
		Rap_GAP	460..639	CDD:460463	85/179 (47%)
sipa1	XP_002935408.2	Rap_GAP	371..550	CDD:460463	85/179 (47%)
		PDZ_SIPA1-like	717..789	CDD:467227	9/71 (13%)