Protein Alignment RapGAP1 and sipa1l3

DIOPT Version :10

• Sequence 1: NP_001097114.2
• Gene: RapGAP1 / 34032
• FlyBaseID: FBgn0264895
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: XP_002940653.2
• Gene: sipa1l3 / 100487745
• XenbaseID: XB-GENE-494440
• Length: 1690
• Species: Xenopus tropicalis
• Alignment Length: 1071
• Identity: 259/1071 - (24%)
• Similarity: 411/1071 - (38%)
• Gaps: 332/1071 - (30%)

  Fly     1 MSSYRTLVDHGHPII--VGS-SEISLAPSSAASSPKPLHRMIKYWRN----SSGKIPG-----LR 53
            :.|..|...:|.|:.  .|| |.|::...|..|    ...|:|.::|    .|||.|.     ||
 Frog   163 VESRGTKFTNGMPLFREYGSTSSINVQGISEQS----FFDMLKDFKNEKPGQSGKSPDQGNSLLR 223

  Fly    54 KSESFAEYRRHSSNSAT-ISGG--------------------SGGRSSTSSARQLQYQRLEMESC 97
            :..|.|.......:|.| :..|                    .|..|.:|..|:|:..:.|.|..
 Frog   224 EDSSMASSLHLVGSSITDLRNGQFQKDDPGLKDKEKLRKKNTKGDSSDSSLFRKLRNNKNESEPG 288

  Fly    98 ENIDMLTEPLR------------------RQHAFMAN----TQKQQPAGGGSGSGSVTHSPERLR 140
            .:.:...|.::                  ..:...||    .|::....|.|.:.:|:.:..|..
 Frog   289 RSFNEQDESIKPWLCPKTFAHYDVQSMLFNLNEIAANRTYVAQRRNTTTGASAASAVSLAVSRAY 353

  Fly   141 G------ATTATQDLFELLERVQCSRLDDQRCVLPAYFSQN--HHRGSNASEERVPQ-PHSPHDS 196
            |      :.|:|:||                     .|.:|  ...|.|.|.|.:.. ||..:::
 Frog   354 GLGNIDPSFTSTEDL---------------------NFKENLEQDMGDNNSNELLLNCPHFRNET 397

  Fly   197 HAHPHNGGLQHSGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQLLSNGHHYQSQ 261
                  |||.          ..|.|.|....|:.|.|                   ..|....|.
 Frog   398 ------GGLS----------ERNVSFSKASLGTPCGS-------------------EGGFLEPSL 427

  Fly   262 SSVSSNSSI-VSAIPASQRLLEEALAKPAPYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTT 325
            :...:|:|| |..:|..:   :::..:...|.:              ||
 Frog   428 TMYCTNASISVLEVPKEK---QKSQGRLKHYSI--------------EH---------------- 459

  Fly   326 WMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILLSIKTENVAN------QEHMRILMRLRT 384
                  .|..|:.|:.::..:||.|..|:|::|||:.:|:|.|.:.:      |.|.||:.|
 Frog   460 ------VDLGAQYYQEYFHGKEHCNYFGVDDKLGPVAVSLKREKLEDSKEFGLQYHYRIIFR--- 515

  Fly   385 GTMHELLPVSCLLPQ---PSPAKMAHTLNENITVEHFMPIL-------C-------PKASQLISV 432
              ..||:.:..::.:   ||.||  |.....:.::..:..:       |       .|.::.:..
 Frog   516 --TSELVTLRGMIQEDAVPSVAK--HGTVRGLPLKDVLEAVILELNTQCLRLAMNSSKVTEQLLK 576

  Fly   433 YDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHKGYRGGLDIQNG 497
            .||..|....|.|:||.:.||::|||::.|:...|||:||:.:||:::.|:....|...||.:..
 Frog   577 LDEQGLCRKHKVGILYCKAGQSSEEEMYNNEYAGPAFEEFMSLLGEKVCLRGFSKYSAQLDTKTD 641

  Fly   498 HTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQETNT-PFSPDMIASH 561
            .||..::|..:::.|||||||||||:|..:.|||.||||||||||.::|||... ||:|..|.||
 Frog   642 STGTHSLYTSYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIVTVIFQEPGALPFTPQNIRSH 706

  Fly   562 FLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACY 626
            |.|.||:|:..||.|.:..|.|:||...|||.|||.:|:...|||...|::|:|.|:||||||.:
 Frog   707 FQHVFIIVRVFEPCTENVCYSVAVTRSKDVPPFGPPVPSGVPFRKSDVFRDFLLAKVINAENAAH 771

  Fly   627 KAEKFAKLEQRTRTSLLQNLCE---------------------ELREKTRDFLGTDLSQTSAGSP 670
            |::||..:..|||...:::|.|                     :.:|:||..:|:::.  |||:.
 Frog   772 KSDKFHTMATRTRQEYIKDLAENYITNTPIDTSGKFNLISLTSKKKERTRPRIGSEMQ--SAGAL 834

  Fly   671 TPETPKAESGSG---------GNAGSRFIDTVKKALIMRVRSQSVDTGNGHGP---------GQT 717
            :......:...|         .|.....|:|..|.::.......|   .|..|         |:.
 Frog   835 SWRVVAQDFSRGAETECALGISNEFMVLIETATKEVVFNCYCADV---IGWTPEPLSLKIFYGRG 896

  Fly   718 DKFSVNTKLGTLNSKKETHPEMQTPNLNTCSRTASKSSSKSKSSNESTSSSPDITSRQANNNNTN 782
            |...:.|..|.....||....::.  :.|...|.                  |:|.|:   |...
 Frog   897 DHILIRTLDGNGEDIKEIVQRLKI--MTTGCETV------------------DMTLRR---NGLG 938

  Fly   783 SIGGHLPQNGTGGGVVAAAVS----AAQNGV-----------VAVATMS--------ETS----- 819
            .:|.|:..:||     .|.|.    |.|.|:           |||.|::        .||
 Frog   939 QLGFHVKYDGT-----VAEVEEYGFAWQAGLRQGSRLVEICKVAVVTLTHDQMIDLLRTSVTVKV 998

  Fly   820 ------DDS----------SLNSVDLDPMMAHLDGGATYIDSDTGLESMSSAEATTKACSLCLDG 868
                  :|.          .|:||:...|.....|......|:|..:...||
 Frog   999 VIIPPHEDGVPRRGLFEAYELSSVEHKEMENSTSGTRPPFRSNTAWQWSGSA------------- 1050

  Fly   869 VQSTIMGSSPSNETI-----VKIENLRQEVT 894
               |..|:|||.:.:     :.:..|.::.|
 Frog  1051 ---THHGASPSQKWVTPGHALSLNRLPKQAT 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:460481	2/20 (10%)
		Rap_GAP	460..639	CDD:460463	85/179 (47%)
sipa1l3	XP_002940653.2	Rap_GAP	604..784	CDD:460463	85/179 (47%)
		PDZ_SIPA1-like	929..1001	CDD:467227	19/79 (24%)
		SPAR_C	1407..1634	CDD:463383