DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RapGAP1 and garnl3

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	XP_031747097.1	Gene:	garnl3 / 100486787	XenbaseID:	XB-GENE-986411	Length:	1021	Species:	Xenopus tropicalis

Alignment Length:	454	Identity:	156/454 - (34%)
Similarity:	235/454 - (51%)	Gaps:	58/454 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 LSGVVSASGCQL--LSNGHHYQSQSSVSSNSSIVSAIPASQRLLEEALAKPAPYPMILLPLHGGY 302
            ||.|....||:.  .|..|:...:..:||::.  .||..:.|...|                .|.
Frog    41 LSSVSEDLGCRRGEFSRKHYGSVELLISSDAD--GAIQRAGRFRVE----------------NGS 87

  Fly   303 WMDGTEHECGYDARGNPLL--PQ--TTWMAKFETDDTAKCYRRFYAAREHSNLIGLDEQLGPILL 363
            ..:.|::..|...|.:..|  |:  |.|            |.:::..:.|.|.:|.|.:..|..|
Frog    88 SDESTDYTPGTWRRTDVHLENPEYHTRW------------YFKYFLGKVHQNYVGTDAEKNPFFL 140

  Fly   364 SIKTENVANQ---EHMRILMRLRTGTMHELLPVSCLLPQPSPAKMAHTLNENITVEHF----MPI 421
            |:...:..||   ::..||.| :|||....||. |    |:......::...:.::.|    ..|
Frog   141 SVVLSDQNNQRVPQYRAILWR-KTGTQKICLPY-C----PTKTLSVKSILSAMNLDRFEKSPREI 199

  Fly   422 LCPKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDEFLDVLGQRIRLKDHK 486
            |.|:..:.:.|.:|.....:|||||||.:.||.|::|:|.|:..|.:|.:.|::||..|.||...
Frog   200 LNPEIQKDLLVLEEQEGSVNFKFGVLYAKDGQLTDDEMFSNEAGSESFQKMLNLLGDTITLKSWV 264

  Fly   487 GYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRHIGNDIVAIVFQ---E 548
            |||||||.:|..||..:||.|::..||||||||:||:::.:.||::||||||||||.||||   |
Frog   265 GYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGDE 329

  Fly   549 TNTPFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNPAVFRKGQEFKEF 613
            .::.|.|.||.|||.|.|.:|:   .|..:..|::.:.:.:.||.|||.||:|.||...|||::|
Frog   330 ASSAFKPSMIRSHFTHIFALVR---YNKQNDSYRLKIFSEESVPLFGPPLPSPPVFTDHQEFRDF 391

  Fly   614 ILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTSAGSPTPETPKA 677
            :|.||||.|.|..:...||:..|||...|:::|.::|..   |.....|::.|.....||:||:
Frog   392 LLVKLINGEKATLETPTFAQKRQRTLDMLIRSLYQDLMP---DLHKNMLNRRSFSDVLPESPKS 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	87/181 (48%)
garnl3	XP_031747097.1	Rap_GAP	238..416	CDD:396632	86/180 (48%)
garnl3	XP_031747097.1	CNH	512..814	CDD:395630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845465at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010