DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RapGAP1 and tsc2

DIOPT Version :9

Sequence 1:	NP_001097114.2	Gene:	RapGAP1 / 34032	FlyBaseID:	FBgn0264895	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	XP_012825619.2	Gene:	tsc2 / 100170546	XenbaseID:	XB-GENE-981706	Length:	1808	Species:	Xenopus tropicalis

Alignment Length:	795	Identity:	157/795 - (19%)
Similarity:	259/795 - (32%)	Gaps:	242/795 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GHPIIVGSSEISLAPSSAASSPKPLHRMIKYWRNSSGKIPGLRKSESFAEYRRHSSNSATISGGS 75
            |.|:.....:....|.:.|..|....:|.|.....:..:|.|.:..:....||.:.|::.:....
Frog  1137 GTPLSASMGQPGATPVTRAEKPSRRTQMKKEKTTLADFVPVLTQGWAEVLVRRPTGNTSWLMSLE 1201

  Fly    76 GGRSSTSSARQLQYQRLEMESCENIDMLTEPLRRQHAFMANTQKQQPAGGGSGSGSVTHSPERLR 140
            ...|..||    ....:.::...|..|..|.|:.............||  .:.|.|.|......|
Frog  1202 NPLSPFSS----DINNMPLQELSNALMAAERLKEHRETALYKSLSVPA--STLSPSTTKCTLLQR 1260

  Fly   141 GATTATQDLF-------ELLERVQCSRLDDQRCVLPAYFSQNHHRGSNASEERVPQPHSPHDSHA 198
            ..|.|:..|.       :||..:..:    :.|.:|...:|     ::...|.|..|
Frog  1261 ANTVASVSLVTQSSGQGKLLRSISWA----ESCAVPEEGAQ-----ADGEAEEVSTP-------- 1308

  Fly   199 HPHNGGLQH-------------SGSRATLRHSMNHSSSSTVSGSACSSTPASPQLSGVVSASGCQ 250
                ||.|.             |..::..:......||||.|....::|......:|.:...|.
Frog  1309 ----GGSQELEDFEAVVSEDTTSEEKSAKKMECISRSSSTSSQEESAATQTEESEAGGIPIEGS- 1368

  Fly   251 LLSNGHHYQSQSSVSSNSSIVS---------------------------AIPASQRLLEE----- 283
              :....:|:.|..||:..:.:                           ..|.|.|...|
Frog  1369 --TREVPFQTLSKSSSSPELQTLQELPKELGPTEDIKKPSADFKTLPHVENPLSHRTKSEEERSA 1431

  Fly   284 -ALAKP------APYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQTTWMAKFETDDTAKCYRR 341
             |||||      .|...:|.|          :...|:..||:.:          ...:.::..||
Frog  1432 GALAKPEGEMRLEPELPVLSP----------QSPTGHRPRGHTI----------SDSEPSRRGRR 1476

  Fly   342 FYAAREHSNLIGLDEQLGPI---LLSIKTENVANQEHMRILMRLRTGTMHELL-------PVSCL 396
            |              |:.|.   ..|.|.|.|...:...:.::|    .|...       |:  |
Frog  1477 F--------------QVDPFKNSTKSTKAEKVPGIDPSFVFLQL----YHSPFFGDESNKPI--L 1521

  Fly   397 LPQPSPAKMAHTLNENITVEHFMPILCPKASQLISVYDEHVLVSHFKFGVLYQRYGQT-TEEELF 460
            :|...            |.|..|.:|     ..|..||.|      |.||||...||. .|..:.
Frog  1522 VPNTQ------------TFERTMGLL-----DRIPPYDTH------KIGVLYVGEGQVGNERAIL 1563

  Fly   461 GNQQTSPAFDEFLDVLGQRIRLKD---HKGYRGGLDIQNGHTGDTAVYEVFKEREIM---FHVST 519
            .|:..|..:.:||..||:.|.|||   .|.:.||||    ..||...:......:||   |.::|
Frog  1564 SNEHGSYRYTQFLTGLGKLIELKDTQPDKIFLGGLD----GCGDDGQFTYCWHDDIMQVIFQITT 1624

  Fly   520 LLPHTEGDPQQLQRKRHIGNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQPI--EPNTPHTRYK 582
            |:|:.|.||.:..:|||:||:.|.|::.::...:....:...|....:.:||:  |.|.
Frog  1625 LMPNKEIDPNRCNKKRHVGNNFVNIIYNDSGEFYKLGTLKGQFNFVDVNIQPLDCESNL------ 1683

  Fly   583 VSVTARDDVPFFGPTLPNPAVFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLC 647
            |::..|.|:                :...:..:.|:::.:|..:.|.:.|         |..|:.
Frog  1684 VTLQCRKDM----------------EGLVDTSVAKIVSDKNLPFLARQMA---------LHSNMA 1723

  Fly   648 EELR---------------------EKTRDFLGTDLSQTSAGSP-------------TPETPKAE 678
            .::.                     :|.|..:..:|.:.||..|             .|:||...
Frog  1724 SQVHHSRSNPTDIYPSKWIARLRHIKKMRPKIQEELQELSANMPYQVPTMANKPPSQNPQTPPGA 1788

  Fly   679 SGSGGNAGSRFIDTV 693
            ..:|..  :|.|..|
Frog  1789 FETGQR--TRLISAV 1801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368	4/27 (15%)
RapGAP1	NP_001097114.2	Rap_GAP	460..639	CDD:280332	45/186 (24%)
tsc2	XP_012825619.2	DUF3384	54..419	CDD:403160
		Tuberin	549..899	CDD:397554
		Rap_GAP	1563..1749	CDD:396632	47/220 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1559
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030