Protein Alignment RapGAP1 and rap1gapa

DIOPT Version :9

• Sequence 1: NP_001097114.2
• Gene: RapGAP1 / 34032
• FlyBaseID: FBgn0264895
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: NP_001116525.1
• Gene: rap1gapa / 100144557
• ZFINID: ZDB-GENE-080402-9
• Length: 695
• Species: Danio rerio
• Alignment Length: 704
• Identity: 279/704 - (39%)
• Similarity: 386/704 - (54%)
• Gaps: 142/704 - (20%)

  Fly   281 LEEALAKPAPYPMILLPLHGGYWMDGTEHECGYDARGNPLLPQ----TTWMAKFETDDTAKCYRR 341
            :.|.|.:.:|:|:||||..||||::||.||.   :.||.  |:    .|...|.|.:.|||.||:
Zfish    24 VHEVLGRKSPFPLILLPQFGGYWIEGTNHEL---SNGND--PEQFVSPTSRYKLECNTTAKIYRK 83

  Fly   342 FYAAREHSNLIGLDEQLGPILLSIKTENVANQEHMRILMRLRTGTMHELLPVSCLLPQPSPAKMA 406
            .:..:||.|...:|..||.::.|:|.:.:.:|||:|:::|.:..|.|:::|:|||...|:..:||
Zfish    84 HFLGKEHFNYYTVDSALGHLVFSMKYDVIGDQEHLRLMLRTKMKTHHDVIPISCLTEFPNIVQMA 148

  Fly   407 HTLNENITVEHFMPILCPKASQLISVYDEHVLVSHFKFGVLYQRYGQTTEEELFGNQQTSPAFDE 471
            ..:.|.:.|:.|.|:|.||||:||..:||||:.::|||||:||::|||:|||||||.:..|||.|
Zfish   149 KLVCEEVNVDRFFPVLYPKASRLIVTFDEHVISNNFKFGVIYQKFGQTSEEELFGNNEEGPAFVE 213

  Fly   472 FLDVLGQRIRLKDHKGYRGGLDIQNGHTGDTAVYEVFKEREIMFHVSTLLPHTEGDPQQLQRKRH 536
            ||:.|||:|.|.|.||:|||||:.:|.||..:||..|..:||||||||.||:||||.||||||||
Zfish   214 FLEFLGQKIELHDFKGFRGGLDVTHGQTGSESVYHNFHNKEIMFHVSTKLPYTEGDTQQLQRKRH 278

  Fly   537 IGNDIVAIVFQETNTPFSPDMIASHFLHAFIVVQPIEPNTPHTRYKVSVTARDDVPFFGPTLPNP 601
            ||||||||||||.||||.||||||:||||::|||.....:....||||||||||||||||.||||
Zfish   279 IGNDIVAIVFQEENTPFVPDMIASNFLHAYVVVQVENACSDDVLYKVSVTARDDVPFFGPPLPNP 343

  Fly   602 AVFRKGQEFKEFILTKLINAENACYKAEKFAKLEQRTRTSLLQNLCEELREKTRDFLGTDLSQTS 666
            |||:||.||.||:|:||||||.||||||||||||:|||::||:.|.|||...::..:|..
Zfish   344 AVFKKGPEFHEFLLSKLINAEYACYKAEKFAKLEERTRSALLETLYEELHINSQAMMGLG----- 403

  Fly   667 AGSPTPETPKAESGSGGNAGSRFIDTVKKALIMRVRSQSVDT----------GNGHG-------- 713
                 .|..|.|:|.||..|. |.::.|:  ::|.||||:||          .|.|.
Zfish   404 -----GEEDKLENGGGGGGGG-FFESFKR--VIRSRSQSLDTMGLNIRKYTVSNSHSGSFAHNNN 460

  Fly   714 -----------------PGQT-----------------------DKFSVNTKLGTLNSKK----- 733
                             ||::                       .|.....|.|..:|::
Zfish   461 NHHSPETPKPPGISLLVPGKSPSKYGRRGSAIGIGTIEESLIIPGKSPTRKKSGPFSSRRSSAIG 525

  Fly   734 -ETHPEMQTPNLNTCSRTASK------SSSKSKSSNESTSSSPDITSRQANNNNTNSIGGHLPQN 791
             |...|:|..:...||.:..|      :|...||.|.|..|||::...: |::|.......:|:
Zfish   526 IENIQEVQEKSSRECSPSTQKTPDSGHASQDPKSENSSNQSSPEVLITK-NSSNLYCRAPSIPE- 588

  Fly   792 GTGGGVVAAAVSAAQNGVVAVATMSETSDDSSLNSVDLDPMMAHLDGGATYIDSDTGLESMSSAE 856
                   |..:|.:.:...:.|::.|.::..:..                  |.|||:||:|||:
Zfish   589 -------AHDLSRSSSNASSFASVVEENETEATE------------------DYDTGMESLSSAD 628

  Fly   857 ATTKACSLC--------LDGVQSTIMGSSP---------------SNETIVKIE 887
            ...|..|..        :....:|..||||               .|.|.::|:
Zfish   629 TPHKRDSFTYSTWLEDNMSTNSTTSRGSSPGPGRNQQTDGGKNQDQNRTDIRIK 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RapGAP1	NP_001097114.2	GoLoco	147..168	CDD:280368
		Rap_GAP	460..639	CDD:280332	128/178 (72%)
rap1gapa	NP_001116525.1	Rap_GAP	202..381	CDD:280332	128/178 (72%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586375
Domainoid	1	1.000	267	1.000	Domainoid score	I1827
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1513
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163377at33208
OrthoFinder	1	1.000	-	-		FOG0002359
OrthoInspector	1	1.000	-	-		otm25518
orthoMCL	1	0.900	-	-		OOG6_105084
Panther	1	1.100	-	-	LDO	PTHR15711
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1559
SonicParanoid	1	1.000	-	-		X1790
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.890