Protein Alignment Ziz and DOCK7

DIOPT Version :10

• Sequence 1: NP_001260200.1
• Gene: Ziz / 34030
• FlyBaseID: FBgn0260486
• Length: 2298
• Species: Drosophila melanogaster
• Sequence 2: NP_001354490.1
• Gene: DOCK7 / 85440
• HGNCID: 19190
• Length: 2140
• Species: Homo sapiens
• Alignment Length: 2541
• Identity: 661/2541 - (26%)
• Similarity: 1042/2541 - (41%)
• Gaps: 742/2541 - (29%)

  Fly     3 RKFTRGLNKLGSAVQMRENVS-------QLVRESAVLNK-------PL--VVEPIDFEAFIAKNK 51
            |.|.:.:::. .|.::|:.:|       ||::...::..       ||  .|:|:|.|.::..:.
Human     5 RAFAQKISRT-VAAEVRKQISGQYSGSPQLLKNLNIVGNISHHTTVPLTEAVDPVDLEDYLITHP 68

  Fly    52 TVIQNDPQRELLIYPTDDVSEIIMPRKQRTNAKSVADRFDPPNEAIVCPLHGPSMITNGNGHSQV 116
            ..:.:.|.|:|:.:|.||:..:..||..||...:|      |.|:.:.| |....|.:      .
Human    69 LAVDSGPLRDLIEFPPDDIEVVYSPRDCRTLVSAV------PEESEMDP-HVRDCIRS------Y 120

  Fly   117 SRQGSIQSNGSHHNGNGNGHTSSSSSSSLNNSNGHGQLSRKSSQCSNGSSSQKDSSYESALSSIT 181
            :...:|.....|..|.|                            .|.::..|....:..|..
Human   121 TEDWAIVIRKYHKLGTG----------------------------FNPNTLDKQKERQKGLPK-- 155

  Fly   182 LRSNLAQPEEVDEFADDGNA-----EDL------VDGQPHGSRAECTRFTRQALYTYRAKNHLIH 235
                  |..|.|| |.|||:     :||      :|..|.||.| |:.|.        .||.|
Human   156 ------QVFESDE-APDGNSYQDDQDDLKRRSMSIDDTPRGSWA-CSIFD--------LKNSL-- 202

  Fly   236 YKYNAYGGNCHDLPSISPAEELVEEIYEIDADQDRIDEQMTRSQADTITKQGYLLKGPDSASDRM 300
                                                                     ||:....:
Human   203 ---------------------------------------------------------PDALLPNL 210

  Fly   301 FANIGNKSFKRRYCYLRQEIDGTYILELHKDEKQGEAKATIVMDFCTDVVQNPKRGRFCFELRMT 365
            .....|           :|||
Human   211 LDRTPN-----------EEID-------------------------------------------- 220

  Fly   366 TGHKSFTLAAENEQDFKDWLSKISSVLAQNRAQEEKRNASLERHPSI-GSNPSPQLQPPAMDPPT 429
                                          |..:::|.::  ||..: ..:|||..:.|
Human   221 ------------------------------RQNDDQRKSN--RHKELFALHPSPDEEEP------ 247

  Fly   430 FGTLKGLDQSLHPQLMKYGRETDHSIALARREQRRRLFACYQSPVKGSGSDNVEQYREHFGTRLL 494
                  :::...|.:.|                                        ||||.|||
Human   248 ------IERLSVPDIPK----------------------------------------EHFGQRLL 266

  Fly   495 LTCHNLRFRLQCIPQDESSAGGVEQQVEPYITSLALFDAKANRKLSENFYFNVN-EQWAAQLLPN 558
            :.|.:|:|               |.::||...||||:|.|..:|:||||||::| ||....|.|:
Human   267 VKCLSLKF---------------EIEIEPIFASLALYDVKEKKKISENFYFDLNSEQMKGLLRPH 316

  Fly   559 TPVPSSVAGCGVPRKSAEGDERSTACQAPHSLFDGVSAELLRSNRQQFQQLRQCLLSVTAPHADI 623
            .| |:::....                                        |..:.|:|.|..|:
Human   317 VP-PAAITTLA----------------------------------------RSAIFSITYPSQDV 340

  Fly   624 YLVVRIEKILQSG-IAQVTEPYL-----KAGKDPKLGQKVYKAAKSYAQHIGHYRQPFAWAARPL 682
            :||:::||:||.| |.:..|||:     .|.|:.:..:|:...|..:.|.:|.||.||||.|..|
Human   341 FLVIKLEKVLQQGDIGECAEPYMIFKEADATKNKEKLEKLKSQADQFCQRLGKYRMPFAWTAIHL 405

  Fly   683 ---------FKQYSHELDVDP-----------------KREFE-------------FSP------ 702
                     .::.|.|:::..                 :|..|             |.|
Human   406 MNIVSSAGSLERDSTEVEISTGERKGSWSERRNSSIVGRRSLERTTSGDDACNLTSFRPATLTVT 470

  Fly   703 -IYRQEIPKLKDEELLKLLVDYRKPEK-LSKLTIIPGSLKMQMQFLDQTTPCGLSKSLAPLSTFS 765
             .::||..:|.||:|.|.|.|.|:|.. |.:|..|...||:.:....:.....|:..|..:..:
Human   471 NFFKQEGDRLSDEDLYKFLADMRRPSSVLRRLRPITAQLKIDISPAPENPHYCLTPELLQVKLY- 534

  Fly   766 PSSKQSPTVEVAEFQSQSERDAH-PYTSFCNHLYVYPLSLQFDSQKLFSRARNITVVVELRDGDG 829
            |.|:..||.|:.||.:   ||.: |.|::.|.||:||.||.|.:::  ..||||||.|:...|:
Human   535 PDSRVRPTREILEFPA---RDVYVPNTTYRNLLYIYPQSLNFANRQ--GSARNITVKVQFMYGE- 593

  Fly   830 EYSKPLKCIYGRPGQDLLVSQIACPVLHHNVTPTWYEEIKLRLPLGLFPEHHLLFSFYHVSCNLS 894
            :.|..:..|:|:........:....|::||.:|.::||||::||..|...|||||:||||||
Human   594 DPSNAMPVIFGKSSCSEFSKEAYTAVVYHNRSPDFHEEIKVKLPATLTDHHHLLFTFYHVSC--- 655

  Fly   895 KKRDANAAFETPIGYAWLPLLQKNRICLEEQQLPVAATLPVGYLSI----QPLGWGKGNCGPDIQ 955
             ::..|...|||:||.|:|:||..|:...:..|||:...|....|:    .||        |.::
Human   656 -QQKQNTPLETPVGYTWIPMLQNGRLKTGQFCLPVSLEKPPQAYSVLSPEVPL--------PGMK 711

  Fly   956 WIDNQRNLYTVGLRLDSTVLTADQHLHNFFGHCE--------------RLLEGGKTGAVPAETET 1006
            |:||.:.::.|.:...|::.|.|.:|..||....              |::|..      .|.|.
Human   712 WVDNHKGVFNVEVVAVSSIHTQDPYLDKFFALVNALDEHLFPVRIGDMRIMENN------LENEL 770

  Fly  1007 CKILKAAHAIDMKSLINYLPTVLNELFTLLVHT-----QSEEIGLNVIRLITNIIHLI------- 1059
            ...:.|.::..::.::.:|..:|::|..|::..     |...:|......:.:||:.:
Human   771 KSSISALNSSQLEPVVRFLHLLLDKLILLVIRPPVIAGQIVNLGQASFEAMASIINRLHKNLEGN 835

  Fly  1060 SDQAKRSDLLGAYVKYVFHAP------------------YYSQQTARQRTVHGELCRHLPYLLNP 1106
            .||..|:.||.:|:.|||..|                  :|:.. ||.......|..:....|:.
Human   836 HDQHGRNSLLASYIHYVFRLPNTYPNSSSPGPGGLGGSVHYATM-ARSAVRPASLNLNRSRSLSN 899

  Fly  1107 SNPD------------------------------------------------------------- 1110
            ||||
Human   900 SNPDISGTPTSPDDEVRSIIGSKGLDRSNSWVNTGGPKAAPWGSNPSPSAESTQAMDRSCNRMSS 964

  Fly  1111 ----------------------------FLIVNKFMRYSSI-----FFDLIIKSMAQHLLATGRI 1142
                                        :::.:..:|.|::     ||:|::|||..||....::
Human   965 HTETSSFLQTLTGRLPTKKLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMVHHLYFNDKL 1029

  Fly  1143 RMLRNERFPKEYGDRVEQLIKALMPYITTRFEDLSEETHLLNRSLAKFVRQCLSYMDRGFVFRLI 1207
            ...|..|||:.:.|.:..|:..:...|.:||:..:|....||.|||.|:...||.|||||||.||
Human  1030 EAPRKSRFPERFMDDIAALVSTIASDIVSRFQKDTEMVERLNTSLAFFLNDLLSVMDRGFVFSLI 1094

  Fly  1208 R-CYMGE----FSPGNPRILHEYKFNFLQEICQHEHYVPLNLP-FVLNPKNRP------------ 1254
            : ||...    :|..||.:|...:.:||:.||.|||||.|||| .:|.|...|
Human  1095 KSCYKQVSSKLYSLPNPSVLVSLRLDFLRIICSHEHYVTLNLPCSLLTPPASPSPSVSSATSQSS 1159

  Fly  1255 --------PEMMQHFTLSEQFCRQHFLSGLLLQELKSSLNEVGH----VRRHALGIFKDLLAKHE 1307
                    .::...|.||..|.:||:|:||:|.||...|:....    :.:..:.:..:||:.|:
Human  1160 GFSTNVQDQKIANMFELSVPFRQQHYLAGLVLTELAVILDPDAEGLFGLHKKVINMVHNLLSSHD 1224

  Fly  1308 LDNRYQQKGQLSRIALLYVPWLGVVMDNIHRIDDLSESGACTPNGHVYADSASYTKRLSCSSSYV 1372
            .|.||......:|:|:||:|.:|::|:.:.::.|.:|:       |      :...|..|.::..
Human  1225 SDPRYSDPQIKARVAMLYLPLIGIIMETVPQLYDFTET-------H------NQRGRPICIATDD 1276

  Fly  1373 FSKDSSTFGSLTSTPRSKNRLTMHCDQASPYRTSVHMKEHNYLAAIAGQPISNGISNLSLNSNTD 1437
            :..:|   ||:.|                                   |.::..|:..|:...|.
Human  1277 YESES---GSMIS-----------------------------------QTVAMAIAGTSVPQLTR 1303

  Fly  1438 SGHSQDTTTIGAYTNGDTDVALRNGHNRSVSVTHAQILSRCDKFSSVESKDLLLGFLFIIKHLSQ 1502
            .|....|:|.|.                    .|.       .||:..|:.||:..|:::|:..:
Human  1304 PGSFLLTSTSGR--------------------QHT-------TFSAESSRSLLICLLWVLKNADE 1341

  Fly  1503 EQMIGWWQNCNESETLQFLSILDLCLLQFRYVGKK----------------------SVVITTET 1545
            ..:..|:.:.:..:..:.|.:|.||:..|.|.|||                      :::.:...
Human  1342 TVLQKWFTDLSVLQLNRLLDLLYLCVSCFEYKGKKVFERMNSLTFKKSKDMRAKLEEAILGSIGA 1406

  Fly  1546 RQ-------GRLAKANTLPARTQPPTGLENGSQEQQPSSGTLNQTREHLLEDIDTLARNQL---A 1600
            ||       |:|..........:.|:|...||||.......:...|:: .|.:|. :|.::   |
Human  1407 RQEMVRRSRGQLGTYTIASPPERSPSGSAFGSQENLRWRKDMTHWRQN-TEKLDK-SRAEIEHEA 1469

  Fly  1601 LYESNLATEVGMIILDCLGLYVLQFRQLLADSLVLPKVARVYLRFLQLGQSERLSKHVFAALRAF 1665
            |.:.|||||..:||||.|.:.|.......:...:|..|.:|.|..:...||....:|.||..||.
Human  1470 LIDGNLATEANLIILDTLEIVVQTVSVTESKESILGGVLKVLLHSMACNQSAVYLQHCFATQRAL 1534

  Fly  1666 INNYAVALFKGNAMLCGQMVYELLKACDSRLVEIRHESCAVLYLLMRSNFEFSGRKALTRVHLQV 1730
            ::.:...||:.....|..:...||:.|.|.:..||..:.|.||||||.|||.....|  ||.:||
Human  1535 VSKFPELLFEEETEQCADLCLRLLRHCSSSIGTIRSHASASLYLLMRQNFEIGNNFA--RVKMQV 1597

  Fly  1731 IISVSQMIGNVIGLNNARFQESLSIINSYANSDKAMKGTGFPMEVKDLTRRVRTVLMATAQMQAH 1795
            .:|:|.::|.....|....:.||..|.:||..|..::.|.||.:|:||...:..:|..|.:|:.|
Human  1598 TMSLSSLVGTSQNFNEEFLRRSLKTILTYAEEDLELRETTFPDQVQDLVFNLHMILSDTVKMKEH 1662

  Fly  1796 HMDPERLLELQYSLANSYASTPELRHTWLVTMARNHEQNGNLSEAACCHLHIAALMCEYLR---- 1856
            ..|||.|::|.|.:|..|.::|:||.|||..||..|.:..|.:|||.|.:|.|||:.|||.
Human  1663 QEDPEMLIDLMYRIAKGYQTSPDLRLTWLQNMAGKHSERSNHAEAAQCLVHSAALVAEYLSMLED 1727

  Fly  1857 ---LKGGCTLSWSSTAFGKISTNIPLDEQGLKLDAGAQDSQ-------YTEQMLLEQLKLCADFL 1911
               |..||      ..|..||:|: |:|..:..|..:.|.:       :||..|:..|:..|...
Human  1728 RKYLPVGC------VTFQNISSNV-LEESAVSDDVVSPDEEGICSGKYFTESGLVGLLEQAAASF 1785

  Fly  1912 DRAERFECLGELYKLILPMYERDRSYQDLAHCYEHLTQAYNKIVEVNRSGKRMLGRFYRVVFYGL 1976
            ..|..:|.:.|:||:::|::|.:|..:.|:..:..|.:|::|||..:...:||.|.::||.|||.
Human  1786 SMAGMYEAVNEVYKVLIPIHEANRDAKKLSTIHGKLQEAFSKIVHQSTGWERMFGTYFRVGFYGT 1850

  Fly  1977 MYFEEDHAIEFVYKEPKLTSLSEISERLAKQYKEKFGADVVKMIMDSSPVKVDELDAKLAYIQVT 2041
            .:.:.|.. |||||||.:|.|:|||.||...|.|:||.|||::|.||:||...:||...||||:|
Human  1851 KFGDLDEQ-EFVYKEPAITKLAEISHRLEGFYGERFGEDVVEVIKDSNPVDKCKLDPNKAYIQIT 1914

  Fly  2042 HVIPFFSKDELDQRLNEFEQNHDVDTFMYETPFTKSGAARGSVEEQWKRKTVIKTQYSFPYVLKR 2106
            :|.|:|...|:..|:..|::|:::..|||.||||..|.|.|.:.||:||||::.|.::|||:..|
Human  1915 YVEPYFDTYEMKDRITYFDKNYNLRRFMYCTPFTLDGRAHGELHEQFKRKTILTTSHAFPYIKTR 1979

  Fly  2107 IPVKSREIIELSPIEVAIDEMQSKVSELE-EIILPPADVKKLQLRLQGSVAVTVNAGPLAYAHAF 2170
            :.|..:|.|.|:||||||::||.|..||. .....|||.|.||:.|||||..|||.|||..|..|
Human  1980 VNVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPADPKMLQMVLQGSVGTTVNQGPLEVAQVF 2044

  Fly  2171 L-----DAKVVNNFSMDRVGDLKDVFRDFIVVCQKALFLNERIISADQKEYHHVLKENYEKLCQA 2230
            |     |.|:..:.:     .|:..|:||...|:.||..|:.:|..|||||...|:.||.:|.:|
Human  2045 LSEIPSDPKLFRHHN-----KLRLCFKDFTKRCEDALRKNKSLIGPDQKEYQRELERNYHRLKEA 2104

  Fly  2231 LSELLD 2236
            |..|::
Human  2105 LQPLIN 2110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ziz	NP_001260200.1	DOCK_C-D_N	37..>81	CDD:463380	12/43 (28%)
		PH_DOCK-D	278..405	CDD:270087	8/126 (6%)
		C2_Dock-D	793..981	CDD:176079	67/191 (35%)
		DHR2_DOCK_D	1818..2231	CDD:212567	175/432 (41%)
DOCK7	NP_001354490.1	DOCK_C-D_N	52..161	CDD:463380	29/157 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..183		13/53 (25%)
		C2_Dock-C	560..737	CDD:176078	67/191 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	888..971		6/82 (7%)
		DHR2_DOCK7	1644..2118	CDD:212576	193/480 (40%)