Protein Alignment Ziz and DOCK5

DIOPT Version :10

• Sequence 1: NP_001260200.1
• Gene: Ziz / 34030
• FlyBaseID: FBgn0260486
• Length: 2298
• Species: Drosophila melanogaster
• Sequence 2: NP_079216.4
• Gene: DOCK5 / 80005
• HGNCID: 23476
• Length: 1870
• Species: Homo sapiens
• Alignment Length: 2127
• Identity: 375/2127 - (17%)
• Similarity: 688/2127 - (32%)
• Gaps: 677/2127 - (31%)

  Fly   261 IYEIDADQDRIDEQMTRSQADTI--------TKQGYLLKGPDSASDRMFANIGNKS----FKRRY 313
            ||..:|.|   |.:::....||:        ..:||.|:              |||    |...|
Human    16 IYNYNASQ---DVELSLQIGDTVHILEMYEGWYRGYTLQ--------------NKSKKGIFPETY 63

  Fly   314 CYLRQEIDGTYILELHKDEKQGEAKATIVMDFCTDVVQNPKRGRFCFELRMTTGHKSFTLAAENE 378
            .:|::    ..:.:|.:.|.....:..:|.:..:.:.:      :....|....:...||..:.:
Human    64 IHLKE----ATVEDLGQHETVIPGELPLVQELTSTLRE------WAVIWRKLYVNNKLTLFRQLQ 118

  Fly   379 Q---DFKDWLSKI-SSVLAQNRAQEEKRNASLE-RHPSIGSNPSPQLQPPAMDPPTFGTLKGLDQ 438
            |   ...:|.|:| |..|.::...|.|:..:.: .|    .|....|.....|..  |.:...|:
Human   119 QMTYSLIEWRSQILSGTLPKDELAELKKKVTAKIDH----GNRMLGLDLVVRDDN--GNILDPDE 177

  Fly   439 SLHPQLMKYGRETDHSIALARREQRRRLFACYQSPVKGSGSDNVEQYREHFGTRLLLTCHN---- 499
            :....|.|     .|.:|..|.|:            |.....::.|..:..|..:..|.|.
Human   178 TSTIALFK-----AHEVASKRIEE------------KIQEEKSILQNLDLRGQSIFSTIHTYGLY 225

  Fly   500 LRFR-LQCIPQDESSAGGVEQQVEPYITSLALFDAKANRKLSENFYFNVNEQWAAQLLPNTPVPS 563
            :.|: ..|         .:.:..|.:   :||:|...:..:|||:..    :|.:.
Human   226 VNFKNFVC---------NIGEDAELF---MALYDPDQSTFISENYLI----RWGSN--------- 265

  Fly   564 SVAGCGVPRKSAEGDERSTACQAPHSLFDGVSAELLRSNRQQFQQLRQCLLSVTAPHADIYLVVR 628
                 |:|::.    |:....||..:  |..|.:|:|.                          |
Human   266 -----GMPKEI----EKLNNLQAVFT--DLSSMDLIRP--------------------------R 293

  Fly   629 IEKILQSGIAQVTEPYLKAGKDPKLGQKVYKAAKSYAQHIGHYRQPFAWAARPL----------- 682
            :..:.|  |.:|....||.||                :|....|:||..|...:
Human   294 VSLVCQ--IVRVGHMELKEGK----------------KHTCGLRRPFGVAVMDITDIIHGKVDDE 340

  Fly   683 -------FKQYSHELDVDPKREFEFSPIYRQEIPKLKDEELLKLL--------VDYRKPEKLSKL 732
                   |:|.:.|..: .:|:...||:....:.. ::|.|..:|        |:::.......|
Human   341 EKQHFIPFQQIAMETYI-RQRQLIMSPLITSHVIG-ENEPLTSVLNKVIAAKEVNHKGQGLWVSL 403

  Fly   733 TIIPGSL-KMQMQF---LDQTTPCGLSKSLAPLSTFSPSSKQSPTVEVAEFQSQSERDAHPYTSF 793
            .::||.| ::|..|   :|::|  .:::.:.......|...:
Human   404 KLLPGDLTQVQKNFSHLVDRST--AIARKMGFPEIILPGDVR----------------------- 443

  Fly   794 CNHLYVYPLSLQFDSQKLFSRARNITVVVELRDGDGEYSKPLKCIYGRPGQDLLVSQIACPVLHH 858
             |.:||..:..:||..|. ...:|:.|.:.:.|.:|:..:  |.|:...|.: .:|:....|.:.
Human   444 -NDIYVTLIHGEFDKGKK-KTPKNVEVTMSVHDEEGKLLE--KAIHPGAGYE-GISEYKSVVYYQ 503

  Fly   859 NVTPTWYEEIKLRLPLGLFPEHHLLFSFYHVSCNLSKKRDANAAFETPIGYAWLPLLQKN----- 918
            ...|.|||.:|:.:.:......|:.|:|.|.|.  .:.||.:   |...|.|::.|:..:
Human   504 VKQPCWYETVKVSIAIEEVTRCHIRFTFRHRSS--QETRDKS---ERAFGVAFVKLMNPDGTTLQ 563

  Fly   919 ----------------------------RICLEEQQLPVAATLPVGYLSIQPLGWGKGNCGPDIQ 955
                                        ::.:||::|..:..|    ::..|..
Human   564 DGRHDLVVYKGDNKKMEDAKFYLTLPGTKMEMEEKELQASKNL----VTFTPSK----------- 613

  Fly   956 WIDNQRNLYTVGLRLDSTVLTADQHL----------HNFFGHCERLLEGGKTGAVPAETETCKIL 1010
              |:.::.:.:...:.||.||.:..|          .|...:.::|:|
Human   614 --DSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKKLME----------------- 659

  Fly  1011 KAAHAIDMKSLINYLPTVLNELFTLLVH-TQSEEIGLNVIRLITNIIHLISDQAKRSDLLGAYVK 1074
                 :|...::.:|...|:.||.:::. :.||.....|...:..||.||.|           :|
Human   660 -----VDGGEIVKFLQDTLDALFNIMMEMSDSETYDFLVFDALVFIISLIGD-----------IK 708

  Fly  1075 YVFHAPYYSQQTARQRTVHGELCRHLPYLLNPSNPDFLIVN--------------KFMRYSSIFF 1125
            :....|      ..:..::......|.|:......:|.:.|              |.::|   .|
Human   709 FQHFNP------VLETYIYKHFSATLAYVKLSKVLNFYVANADDSSKTELLFAALKALKY---LF 764

  Fly  1126 DLIIKSMAQHLLATGRIRMLRNERFPKEYGDRVEQLIKALMPYITTRFEDLSEETHLLNRSLAKF 1190
            ..||:|...:|      |.....:...|:.:.:.||..|.              ..|::|.|.:.
Human   765 RFIIQSRVLYL------RFYGQSKDGDEFNNSIRQLFLAF--------------NMLMDRPLEEA 809

  Fly  1191 VR---QCLSYMDRGFVFRLIRCYMGEFSPGNPRILHEYKFNF----LQEI-CQHEHYVPLNLPFV 1247
            |:   ..|.|:                    |.|:::.|..|    |..: |:....:|.| ..|
Human   810 VKIKGAALKYL--------------------PSIINDVKLVFDPVELSVLFCKFIQSIPDN-QLV 853

  Fly  1248 LNPKNRPPEMMQHFTLSEQFCRQHFLSGLLLQELKSSLNEVGHVRRHALGIFKDLLAKHELDNRY 1312
            ....|...::::.....:..||:..|. ||..:|...|::..:...|
Human   854 RQKLNCMTKIVESTLFRQSECREVLLP-LLTDQLSGQLDDNSNKPDH------------------ 899

  Fly  1313 QQKGQLSRIALLYVPWLGVVMDNIHRIDDLSESGACTPNGHVYADSASYTKRLSCSSSYVFSKDS 1377
            :...||              :.||..:.|..:.||...  |:........:|:
Human   900 EASSQL--------------LSNILEVLDRKDVGATAV--HIQLIMERLLRRI------------ 936

  Fly  1378 STFGSLTSTPRSKNRLTMHCDQASPYRTSVHMKEHNYLAAIAGQPISNGISNLSLNSNTDSGHSQ 1442
                         ||..:..::.||:..|       ::|.:           ::|....|..|
Human   937 -------------NRTVIGMNRQSPHIGS-------FVACM-----------IALLQQMDDSH-- 968

  Fly  1443 DTTTIGAYTNGDTDVALRNGHNRSVSVTHAQILSRCDKFSSVESKDLLLGFLFIIKHLSQEQMIG 1507
                   |:           |..|...|...|:            |.|:....:.|.|..:.:..
Human   969 -------YS-----------HYISTFKTRQDII------------DFLMETFIMFKDLIGKNVYA 1003

  Fly  1508 W-WQNCNESETLQFLSILDLCLLQFRYVGKKSVVITTETRQGRLAKANTLPARTQPPTGLENGSQ 1571
            . |...|.::...||          |.:.:.:.|:|.                    ..::..|.
Human  1004 KDWMVMNMTQNRVFL----------RAINQFAEVLTR--------------------FFMDQASF 1038

  Fly  1572 EQQPSSGTLN-----QTREHL-LEDIDTLARNQLALYESNLATEVGMIILDC---LGLYVLQFRQ 1627
            |.|..:...:     .|.|.| ||......||::.....::..|:|..|.|.   ||.:.::|
Human  1039 ELQLWNNYFHLAVAFLTHESLQLETFSQAKRNKIVKKYGDMRKEIGFRIRDMWYNLGPHKIKF-- 1101

  Fly  1628 LLADSLVLPKVARVYLRFLQLGQSERLSKHVFAALRAFINNYAVALFKGNAMLCGQMVYELLKAC 1692
                   :|                                              .||..:|:..
Human  1102 -------IP----------------------------------------------SMVGPILEVT 1113

  Fly  1693 DSRLVEIRHESCAVLYLLMRSNFEFSGRKALTRVHLQVIISVSQMIGNVIGLNNARFQESL-SII 1756
            .:..||:|..:..:.:.:|:..|.|||.........::|..:.|.:..  |..:.:::..| .::
Human  1114 LTPEVELRKATIPIFFDMMQCEFNFSGNGNFHMFENELITKLDQEVEG--GRGDEQYKVLLEKLL 1176

  Fly  1757 NSYANSDKAMKGTG--FPMEVKDLTRRV---RTVLMATAQMQAHHMDPERLLELQYSLANSY--A 1814
            ..:....|.:..:|  |.:.|..|...:   ||::|       .....|..:....::.|.|  .
Human  1177 LEHCRKHKYLSSSGEVFALLVSSLLENLLDYRTIIM-------QDESKENRMSCTVNVLNFYKEK 1234

  Fly  1815 STPELRHTWLVTMARNHEQNGNLSEAACCHLHIAALMCEYLRLKGGCTLSWSSTAFGKISTNIPL 1879
            ...::...:|..:...|....|.:|||            |..|.....|.||..         |.
Human  1235 KREDIYIRYLYKLRDLHRDCENYTEAA------------YTLLLHAELLQWSDK---------PC 1278

  Fly  1880 DEQGLKLDAGAQDSQ--YTEQMLLEQL-KLCADFLDRAERFECLGELYKLILPMYE-RDRSYQDL 1940
            ....|:     :||.  ||:|.|.|:| :....:.|:.:.:|...:|.|.:...|| :...|:.|
Human  1279 VPHLLQ-----KDSYYVYTQQELKEKLYQEIISYFDKGKMWEKAIKLSKELAETYESKVFDYEGL 1338

  Fly  1941 AHCYEHLTQAYNKIVEVNRSGKRMLGRFYRVVFYGLMYFEEDHAIEFVYKEPKLTSLSEISERLA 2005
            .:..:.....|..|::..|...    .::.|.:||..:........|:|:..:.....:.|.||.
Human  1339 GNLLKKRASFYENIIKAMRPQP----EYFAVGYYGQGFPSFLRNKIFIYRGKEYERREDFSLRLL 1399

  Fly  2006 KQYKEKFGADVVKMIMDSSPVKVDELDAKLAYIQVTHVIPFFS-----KDE--LDQRLNEFEQNH 2063
            .|:..      .:.:..::|...|...:...|:|...|.|..|     ||:  .:|.||.:..|
Human  1400 TQFPN------AEKMTSTTPPGEDIKSSPKQYMQCFTVKPVMSLPPSYKDKPVPEQILNYYRAN- 1457

  Fly  2064 DVDTFMYETPFTKSGA-ARGSVEEQWKRKTVIKTQYSFPYVLKRIPVKSREIIELSPIEVAIDEM 2127
            :|..|.|..||.|... ........|..:|...|.|:||.:||...||.....|:||:|.||:.|
Human  1458 EVQQFRYSRPFRKGEKDPDNEFATMWIERTTYTTAYTFPGILKWFEVKQISTEEISPLENAIETM 1522

  Fly  2128 QSKVSELEEIILPPA-----DVKKLQLRLQGSVAVTVNAGPLAYAHAFLDAKVVNNFSMDRVGDL 2187
            :.....:...:...|     .|..|.:.|.|.|...|..|...|..||...|.:.....|
Human  1523 ELTNERISNCVQQHAWDRSLSVHPLSMLLSGIVDPAVMGGFSNYEKAFFTEKYLQEHPED----- 1582

  Fly  2188 KDVFRDFIVVCQKALFLNERIISADQKEYHHVLKENYEKLCQALSEL 2234
                       |:.:.|.:|:|:.........::.:.|||.:.|..|
Human  1583 -----------QEKVELLKRLIALQMPLLTEGIRIHGEKLTEQLKPL 1618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ziz	NP_001260200.1	DOCK_C-D_N	37..>81	CDD:463380
		PH_DOCK-D	278..405	CDD:270087	25/142 (18%)
		C2_Dock-D	793..981	CDD:176079	41/220 (19%)
		DHR2_DOCK_D	1818..2231	CDD:212567	97/429 (23%)
DOCK5	NP_079216.4	SH3_DOCK1_5_A	12..67	CDD:212984	15/67 (22%)
		DOCK_N	75..434	CDD:465040	80/471 (17%)
		C2	442..637	CDD:472691	41/244 (17%)
		DHR2_DOCK5	1238..1637	CDD:212581	99/434 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1679..1702
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1772..1870