DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ziz and DOCK10

DIOPT Version :10

Sequence 1:NP_001260200.1 Gene:Ziz / 34030 FlyBaseID:FBgn0260486 Length:2298 Species:Drosophila melanogaster
Sequence 2:XP_006712680.1 Gene:DOCK10 / 55619 HGNCID:23479 Length:2206 Species:Homo sapiens


Alignment Length:2343 Identity:822/2343 - (35%)
Similarity:1251/2343 - (53%) Gaps:376/2343 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 KPLVVEPIDFEAFIAKNKTVIQNDPQRELLIYPTDDVSEIIMPRKQRTNAKSVADRFDPPNEAIV 98
            ||.::||:|:|..|.:.:...:|||.::||.:|:||.|...:....||...:|            
Human    57 KPRLLEPLDYETVIEELEKTYRNDPLQDLLFFPSDDFSAATVSWDIRTLYSTV------------ 109

  Fly    99 CPLHGPSMITNGNGHSQVSRQGSIQSNGSHHNGNGNGHTSSSSSSSLNNSNGHGQLSRKSSQCSN 163
                                                                             
Human   110 ----------------------------------------------------------------- 109

  Fly   164 GSSSQKDSSYESALSSITLRSNLAQPEEVDEFADDGNAEDLVDGQPHGSRAECTRFTRQALYTYR 228
                                     ||:.:.     .||:|:              .::|...|.
Human   110 -------------------------PEDAEH-----KAENLL--------------VKEACKFYS 130

  Fly   229 AKNHLIHYKYNAYGGNCHDLPSIS-PAEELVEEIYEIDADQDRIDEQMTRSQADT---------I 283
            ::.|:::|||..|.|:...||... ..|:|....:|||.:....||..|...:..         :
Human   131 SQWHVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEIDHEDADKDEDTTSHSSSKGGGGAGGTGV 195

  Fly   284 TKQGYLLKGPDSASDRMFANIGNKSFKRRYCYLRQEIDGTYILELHKDEK-QGEAKATIVMDFCT 347
            .|.|:|.||..:::......:  :|||:||..|.|..|.:||:..:|||| ..|.|..|.:|.||
Human   196 FKSGWLYKGNFNSTVNNTVTV--RSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIFLDSCT 258

  Fly   348 DVVQNPKRGRFCFELRMTTGHKSFTLAAENEQDFKDWLSKISSVL-------AQNRAQEEKRNAS 405
            .||||.:..::.|||:| .....|.||||.|.|..:|:..::.:|       .|.|...|..:..
Human   259 GVVQNNRLRKYAFELKM-NDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGRRSTELTDLG 322

  Fly   406 LERHPSIGSNPSPQLQPPAMDPPTFGTLKGLDQSLHPQLMKYGRETDHSIALARREQRRRLFACY 470
            |:   |:.::.:.:..|...|        ..:.:||....||..||:.::...|..:|..||:. 
Human   323 LD---SLDNSVTCECTPEETD--------SSENNLHADFAKYLTETEDTVKTTRNMERLNLFSL- 375

  Fly   471 QSP----VKGSGSDNVE------QYREHFGTRLLLTCHNLRFRLQ-CIPQDESSAGGVEQQVEPY 524
             .|    :|....|.:|      .:.|....|:::.|..|...|| |:.::|:..   ...:||:
Human   376 -DPDIDTLKLQKKDLLEPESVIKPFEEKAAKRIMIICKALNSNLQGCVTENENDP---ITNIEPF 436

  Fly   525 ITSLALFDAKANRKLSENFYFNVNEQWAAQLLPNTPVPSSVA------GCGVPRKSAEGDERSTA 583
            ..|:||:|.:.:||:|.:|:.::|.....|:|    :.:|||      ....||:|.|       
Human   437 FVSVALYDLRDSRKISADFHVDLNHAAVRQML----LGASVALENGNIDTITPRQSEE------- 490

  Fly   584 CQAPHSLFDGVSAELLRSNRQQFQQLRQCLLSVTAPHADIYLVVRIEKILQSGIAQVTEPYLKAG 648
               ||  ..|:..|.|:..       :|.:.||:.||::|.||.:|||:|...||...|||:|..
Human   491 ---PH--IKGLPEEWLKFP-------KQAVFSVSNPHSEIVLVAKIEKVLMGNIASGAEPYIKNP 543

  Fly   649 KDPKLGQKVYKAAKSYAQHIGHYRQPFAWAARPLFKQYSHELDVDPKREFEFSPIYRQEIPKLKD 713
            ...|..||:.|:.:.:...:|.||.|||||.|.:||.....:|    |:..|||::|||..|:..
Human   544 DSNKYAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVD----RDSRFSPLFRQESSKIST 604

  Fly   714 EELLKLLVDYRKPEKLSKLTIIPGSLKMQMQFLDQTTPCGLSKSLAPLSTFSPSSKQSPTVEVAE 778
            |:|:||:.|||:.:::||:..|||||.:.:..:....|..::.|..|:..|:..::..|||||.|
Human   605 EDLVKLVSDYRRADRISKMQTIPGSLDIAVDNVPLEHPNCVTSSFIPVKPFNMMAQTEPTVEVEE 669

  Fly   779 FQSQSERDAHPYTSFCNHLYVYPLSLQFDSQKLFSRARNITVVVELRDGDGEYSKPLKCIYGRPG 843
            |...|.:...||..:.|.:|:||..|::||||.|::||||||.:|.::.|.|.:||||||||:||
Human   670 FVYDSTKYCRPYRVYKNQIYIYPKHLKYDSQKCFNKARNITVCIEFKNSDEESAKPLKCIYGKPG 734

  Fly   844 QDLLVSQIACPVLHHNVTPTWYEEIKLRLPLGLFPEHHLLFSFYHVSCNLSKKRDA--NAAFETP 906
            ..|..|.....||||:..|.:.:|:|:.||..|..:||:|||||||:|:::.|.:|  ..|.||.
Human   735 GPLFTSAAYTAVLHHSQNPDFSDEVKIELPTQLHEKHHILFSFYHVTCDINAKANAKKKEALETS 799

  Fly   907 IGYAWLPLLQKNRICLEEQQLPVAATLPVGYLSIQPLGWGKGNCGPDIQWIDNQRNLYTVGLRLD 971
            :|||||||::.::|..:|..:|:|.:||..|||.|....|| :.|.||:|:|..:.|:.|...:.
Human   800 VGYAWLPLMKHDQIASQEYNIPIATSLPPNYLSFQDSASGK-HGGSDIKWVDGGKPLFKVSTFVV 863

  Fly   972 STVLTADQHLHNFFGHCERLLEGGKTGAVPAETETCKIL---KAAHAIDMKSLINYLPTVLNELF 1033
            |||.|.|.|::.||..|::..:............:||.|   :..|||     :::||.:||:||
Human   864 STVNTQDPHVNAFFQECQKREKDMSQSPTSNFIRSCKNLLNVEKIHAI-----MSFLPIILNQLF 923

  Fly  1034 TLLVHTQSEEIGLNVIRLITNII---HLISDQAKRSDLLGAYVKYVFHAPYYSQQTARQRTVHGE 1095
            .:||..:.:||...|.|::|:|:   |  .:|...|  :.:|:|:||     ..:..::||||.|
Human   924 KVLVQNEEDEITTTVTRVLTDIVAKCH--EEQLDHS--VQSYIKFVF-----KTRACKERTVHEE 979

  Fly  1096 LCRHLPYLLNPSNPDFLIVNKFMRYSSIFFDLIIKSMAQHLLATGRIRMLRNERFPKEYGDRVEQ 1160
            |.:::..||. || |...|...:::|..||.:|:|||||||:.|.:|::.|.:|||:.|.:.::.
Human   980 LAKNVTGLLK-SN-DSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLPRPQRFPESYQNELDN 1042

  Fly  1161 LIKALMPYITTRFEDLSEETHLLNRSLAKFVRQCLSYMDRGFVFRLIRCYMGEFSPGNPRILHEY 1225
            |:..|..::..:::|..|||...|.|:|:|:::|.::||||:||:::..|:..||.|:.:.|.:|
Human  1043 LVMVLSDHVIWKYKDALEETRRANHSVARFLKRCFTFMDRGYVFKMVNNYISMFSSGDLKTLCQY 1107

  Fly  1226 KFNFLQEICQHEHYVPL-------NLPFVLNPKNRPPEM----MQHFTLSEQFCRQHFLSGLLLQ 1279
            ||:||||:|||||::||       |:|..|.|.....|:    |..::::.:|||:|||.|:||:
Human  1108 KFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESTQELHASDMPEYSVTNEFCRKHFLIGILLR 1172

  Fly  1280 ELKSSLNEVGHVRRHALGIFKDLLAKHELDNRYQQKGQLSRIALLYVPWLGVVMDNIHRIDDLSE 1344
            |:..:|.|...||..||.:.|:|:|||..|:||::..:.::||.||:|..|:::||:.||     
Human  1173 EVGFALQEDQDVRHLALAVLKNLMAKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRI----- 1232

  Fly  1345 SGACTPNGHVYADSASYTKRL---SCSSSYVFSKDS-STFGSLTSTPRSKNRLTMHCDQASPYRT 1405
                            |.|.|   :.::|...|:|. ||.|...|....|:        |:...|
Human  1233 ----------------YLKDLYPFTVNTSNQGSRDDLSTNGGFQSQTAIKH--------ANSVDT 1273

  Fly  1406 SVHMKEHNYLAAIAGQPISN--------GISNLSLNSNTDSGHSQDTTTIGAYTNGDTDVALRNG 1462
            |......|.:||.:...||.        .:::|..|.:|:...|:.|.......           
Human  1274 SFSKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTNEKSSEKTDNCEKIP----------- 1327

  Fly  1463 HNRSVSVTHAQILSRCDKFSSVESKDLLLGFLFIIKHLSQEQMIGWWQNCNESETLQFLSILDLC 1527
              |.:|:..:.:  |.||....|::.||:.||.|:|.:|.|.:|.:||.....|...|.||||:|
Human  1328 --RPLSLIGSTL--RFDKLDQAETRSLLMCFLHIMKTISYETLIAYWQRAPSPEVSDFFSILDVC 1388

  Fly  1528 LLQFRYVGKKSVVITTETRQGRLAKANTLPARTQPPTGLENGSQEQQPSSGTLNQ----TREH-- 1586
            |..|||:||::::       .::|.|......|| ..|...||.....:||.|:|    |..|  
Human  1389 LQNFRYLGKRNII-------RKIAAAFKFVQSTQ-NNGTLKGSNPSCQTSGLLSQWMHSTSSHEG 1445

  Fly  1587 ----------------------LLEDID---TLARNQLALY-----ESNLATEVGMIILDCLGLY 1621
                                  ||:.:|   |...|::.:.     |:|:||||.:.|||.|.|:
Human  1446 HKQHRSQTLPIIRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLLSLF 1510

  Fly  1622 V----LQFRQLLADSLVLPKVARVYLRFLQLGQSERLSKHVFAALRAFINNYAVALFKGNAMLCG 1682
            .    .|.:|....:.::.:|...|:.|.|:.||....|||||:||.|:..:..|.|:|.|.|||
Human  1511 TQTHQRQLQQCDCQNSLMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSAFFQGPADLCG 1575

  Fly  1683 QMVYELLKACDSRLVEIRHESCAVLYLLMRSNFEFSGRKALTRVHLQVIISVSQMIGNVIGLNNA 1747
            ...||:||.|:.|....:.|:.|:||..||.||||:.:|::.|.|||:|.:|||:|.:. |:..:
Human  1576 SFCYEVLKCCNHRSRSTQTEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIADA-GIGGS 1639

  Fly  1748 RFQESLSIINSYANSDKAMKGTGFPMEVKDLTRRVRTVLMATAQMQAHHMDPERLLELQYSLANS 1812
            |||.||:|.|::||.||.||.:.||.||||||:|:||||||||||:.|..|||.|::||||||||
Human  1640 RFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLVDLQYSLANS 1704

  Fly  1813 YASTPELRHTWLVTMARNHEQNGNLSEAACCHLHIAALMCEYLRLKGG------CTLSWSS---- 1867
            ||||||||.|||.:||:.|.:||:|||||.|::|||||:.|||:.||.      ||.|..|    
Human  1705 YASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYWKVEKICTASLLSEDTH 1769

  Fly  1868 ---------------------TAFGKISTNIPLDEQGLKLDAGAQDSQYTEQMLLEQLKLCADFL 1911
                                 .||..|:.||. :|..:|.|:|.||:.|.|.:|:|||.:|.:||
Human  1770 PCDSNSLLTTPSGGSMFSMGWPAFLSITPNIK-EEGAMKEDSGMQDTPYNENILVEQLYMCVEFL 1833

  Fly  1912 DRAERFECLGELYKLILPMYERDRSYQDLAHCYEHLTQAYNKIVEVNRSGKRMLGRFYRVVFYGL 1976
            .::||:|.:.::.|.|:.::|:.|.::.|:..|..:.::|.|:.||..|.||:.||:|||.|||.
Human  1834 WKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQ 1898

  Fly  1977 MYFEEDHAIEFVYKEPKLTSLSEISERLAKQYKEKFGADVVKMIMDSSPVKVDELDAKLAYIQVT 2041
            .:|||:...|::|||||||.|||||:||.|.|.:|||||.||:|.||:.|...:||.|.||||||
Human  1899 GFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVT 1963

  Fly  2042 HVIPFFSKDELDQRLNEFEQNHDVDTFMYETPFTKSGAARGSVEEQWKRKTVIKTQYSFPYVLKR 2106
            :|.|||.:.|::.|..:||.:|:::.|::|||||.||...|.|.||.||:|::.|.:.||||.||
Human  1964 YVTPFFEEKEIEDRKTDFEMHHNINRFVFETPFTLSGKKHGGVAEQCKRRTILTTSHLFPYVKKR 2028

  Fly  2107 IPVKSREIIELSPIEVAIDEMQSKVSELEEI-ILPPADVKKLQLRLQGSVAVTVNAGPLAYAHAF 2170
            |.|.|:...||:|||||||||..|||||.:: .:...|:.:|||:|||||:|.|||||:|||.||
Human  2029 IQVISQSSTELNPIEVAIDEMSKKVSELNQLCTMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAF 2093

  Fly  2171 LDAKVVNNFSMDRVGDLKDVFRDFIVVCQKALFLNERIISADQKEYHHVLKENYEKLCQALSELL 2235
            |:......:..::|..||::||.|...|.:||.:|||:|..||.||...|:.:|:.:...||.::
Human  2094 LEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSTVM 2158

  Fly  2236 DDE 2238
            :::
Human  2159 NEQ 2161

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZizNP_001260200.1 DOCK_C-D_N 37..>81 CDD:463380 14/43 (33%)
PH_DOCK-D 278..405 CDD:270087 45/143 (31%)
C2_Dock-D 793..981 CDD:176079 87/189 (46%)
DHR2_DOCK_D 1818..2231 CDD:212567 205/444 (46%)
DOCK10XP_006712680.1 DOCK_C-D_N 58..168 CDD:463380 36/230 (16%)
PH_DOCK-D 195..315 CDD:270087 44/122 (36%)
C2_Dock-D 684..873 CDD:176079 87/189 (46%)
DHR2_DOCK10 1709..2154 CDD:212572 206/445 (46%)

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