Protein Alignment Ziz and Dock6

DIOPT Version :10

• Sequence 1: NP_001260200.1
• Gene: Ziz / 34030
• FlyBaseID: FBgn0260486
• Length: 2298
• Species: Drosophila melanogaster
• Sequence 2: XP_038937778.1
• Gene: Dock6 / 367039
• RGDID: 1306517
• Length: 2123
• Species: Rattus norvegicus
• Alignment Length: 2548
• Identity: 677/2548 - (26%)
• Similarity: 1023/2548 - (40%)
• Gaps: 735/2548 - (28%)

  Fly     3 RKFTRGLNKLGSAVQMRENVSQ--------LVRESAVLNKPL--VVEPIDFEAFIAKNKTVIQND 57
            |.|...:|:. .|.::|:.||:        ..|.|:.|..||  |:||:|||..:......::..
  Rat     7 RAFAHKINRT-VAAEVRKQVSRERSGSPHSSRRSSSSLGVPLTEVIEPLDFEDVLLSRPPEVEPG 70

  Fly    58 PQRELLIYPTDDVSEIIMPRKQRTNAKSVADRFDPPNEAIVCPLHGPSMITNGNGHSQVSRQGSI 122
            |.|:::.:|.||:..:..||:.||....|
  Rat    71 PLRDMIEFPADDLELLKQPRECRTTESGV------------------------------------ 99

  Fly   123 QSNGSHHNGNGNGHTSSSSSSSLNNSNGHGQLSRKSSQCSNGSSSQKDSSYESALSSITLRSNLA 187
                                                                             
  Rat   100 ----------------------------------------------------------------- 99

  Fly   188 QPEEVDEFADDGNAEDLVDGQPHGSRAECTRFTRQALYTYRAKNHLIHYKYNAYGGNCHDLPSIS 252
             ||       ||..:..|       ||....::...:...|...||    ..||.      |..:
  Rat   100 -PE-------DGKLDAQV-------RAAVEMYSEDWVIVRRRYQHL----STAYS------PITT 139

  Fly   253 PAEE-----LVEEIYEIDADQDRIDEQMTRSQADTITKQGYLLKGPDSASDRMFANIGNKSFKRR 312
            ..:.     |..:::|    ||...::.|               ||:...|
  Rat   140 ETQRERQKGLTCQVFE----QDTPGDERT---------------GPEDVDD-------------- 171

  Fly   313 YCYLRQEIDGTYILELHKDEKQGEAKATIVMDFCTDVVQNPKRGRFCFELRMTTGHKSFTLAAEN 377
                .|...|:     .:|..:....:.:                  |.||        .|||::
  Rat   172 ----SQHCSGS-----PEDTPRSSGASGV------------------FSLR--------NLAADS 201

  Fly   378 EQDFKDWLSKISSVLAQNRAQE--EKRNASLERHPSIGSNPSPQLQPPAMDPPTFGTLKGLDQSL 440
                      :...|.:..|.|  ::||.:|.|          |.:.||:            .:|
  Rat   202 ----------LLPTLLERAAPEDVDRRNEALRR----------QHRAPAL------------LTL 234

  Fly   441 HPQLMKYGRETDHSIALARREQRRRLFACYQSPVKGSGSDNVEQYREHFGTRLLLTCHNLRFRLQ 505
            :|       ..|...|:.|         |          .:.|..|||||.|:|:.|.:|:|
  Rat   235 YP-------APDEDEAVER---------C----------SHPEPPREHFGQRILVKCLSLKF--- 270

  Fly   506 CIPQDESSAGGVEQQVEPYITSLALFDAKANRKLSENFYFNVNEQWAAQLLPNTPVPSSVAGCGV 570
                        |.::||...:|||:|.:..:|:||||||::|......||
  Rat   271 ------------EIEIEPIFGTLALYDVREKKKISENFYFDLNSDSVKGLL-------------- 309

  Fly   571 PRKSAEGDERSTACQAPHSLFDGVSAELLRSNRQQFQQLRQCLLSVTAPHADIYLVVRIEKILQS 635
               .|.|...:.:..|                       |..:.|||.|..||:|||::||:||.
  Rat   310 ---RAHGTHPAISTLA-----------------------RSAIFSVTYPSPDIFLVVKLEKVLQQ 348

  Fly   636 G-IAQVTEPY--LKAGKDPKLGQKVYK---AAKSYAQHIGHYRQPFAWAA--------------- 679
            | |::..|||  :|.....|..:|:.|   ||:.:...:|.||.||||.|
  Rat   349 GDISECCEPYMVMKEADTVKNKEKLEKLRLAAEQFCTRLGRYRMPFAWTAVHLANIVSSVGPQDR 413

  Fly   680 --------RPLF----------KQYSHELDVDPKREFEFSP-------IYRQEIPKLKDEELLKL 719
                    ||.:          :.||.:   |......|.|       .::||..:|.||:|.|.
  Rat   414 DSDSEGERRPTWAERRRRGPQDRSYSGD---DACSFSSFRPATLTVTNFFKQEAERLSDEDLFKF 475

  Fly   720 LVDYRKPEK-LSKLTIIPGSLKMQMQFLDQTTPCGLSKSLAPLSTFSPSSKQSPTVEVAEFQSQS 783
            |.|.|:|.. |.:|..:...||:.:....:.....||..|..:..: |..:..||.|:.||.:
  Rat   476 LADMRRPSSLLRRLRPVTAQLKIDISPAPENLHFCLSPELLHVKPY-PDPRGRPTKEILEFPA-- 537

  Fly   784 ERDAH-PYTSFCNHLYVYPLSLQFDSQKLFSRARNITVVVELRDGDGEYSKPLKCIYGRPGQDLL 847
             |:.: |:|.:.|.|:|||.||.|.|::  ...||:.|.::...|: :.|:.|..|:|:......
  Rat   538 -REVYAPHTCYRNLLFVYPHSLNFSSRQ--GSVRNLAVRIQYMAGE-DQSQALPVIFGKSSCSEF 598

  Fly   848 VSQIACPVLHHNVTPTWYEEIKLRLPLGLFPEHHLLFSFYHVSCNLSKKRDANAAFETPIGYAWL 912
            ..:...||::||.:|.:|||.|||||..:...|||.|:||||||    :.....|.|||:|:.|:
  Rat   599 TREAFTPVVYHNKSPEFYEEFKLRLPACVTENHHLFFTFYHVSC----QPRPGTALETPVGFTWI 659

  Fly   913 PLLQKNRICLEEQQLPVAATLPVGYLSIQPLGWGKGNCGPDI-----QWIDNQRNLYTVGLRLDS 972
            ||||..|:......|||:...|....|:         ..||:     :|:|..:.:::|.|...|
  Rat   660 PLLQHGRLRTGPFCLPVSVDQPPPSYSV---------LTPDVALPGMRWVDGHKGVFSVELTAVS 715

  Fly   973 TVLTADQHLHNFFGHCERLLEGGKTGAVP------------AETETCKILKAAHAIDMKSLINYL 1025
            :|...|.||..||    .|:...:.|..|            .|.|....|.|......:.|:.:.
  Rat   716 SVHPQDPHLDKFF----TLVHVLEEGIFPFRLKETVLSEGTMEQELRASLAALRLASPEPLVAFS 776

  Fly  1026 PTVLNELFTLLVHT-----QSEEIG-------LNVIRLITNIIHLISDQAKRSDLLGAYVKYVFH 1078
            ..||::|..|:|..     |...:|       .:|..|:...:..:.|......||.|||.|.|.
  Rat   777 HHVLDKLVRLVVRPPVICGQMVNLGRGAFEAMAHVASLVHRNLEAVQDSRGHCPLLAAYVHYAFR 841

  Fly  1079 APYYSQQTARQRTVHGELCRHLP-----------------------YL-----LNPSNPDFLIV- 1114
            .|            .|:|  .||                       ||     ::.||||..:|
  Rat   842 LP------------GGDL--GLPGEVPPATVQAATLARGSGRPASLYLARSKSISSSNPDLAVVP 892

  Fly  1115 ----------------------------------------------------------NKFMRYS 1121
                                                                      :.::..|
  Rat   893 GSVDDEVSRILASKGVDRSHSWVNSAYAPGGSKAVLRRVPPYCGADPRQAIDRNSSRASSYLEAS 957

  Fly  1122 S----------------------------------------IFFDLIIKSMAQHLLATGRIRMLR 1146
            |                                        .||.|::|||..|||...|:...|
  Rat   958 SSALPAPQLRHTVQKLLHEELALQWVVSGSAVRELVLQHAWFFFQLMVKSMELHLLLGQRLDTPR 1022

  Fly  1147 NERFPKEYGDRVEQLIKALMPYITTRFEDLSEETHLLNRSLAKFVRQCLSYMDRGFVFRLIRCYM 1211
            ..|||..:.|.:..|:.::...:.||.....|....||.|||.|:...||..|||::|.|:|.:.
  Rat  1023 KLRFPGRFLDDIAALVASVGLEVITRVHKDMELAERLNASLAFFLSDLLSIADRGYIFSLVRAHY 1087

  Fly  1212 GEF-----SPGNPRILHEYKFNFLQEICQHEHYVPLNLPFV-LNPKNRP---------------- 1254
            .:.     |..||..|...:.:|.:.:|.|||||.||||.. |:|...|
  Rat  1088 KQVATRLQSAPNPAALLTLRMDFTRILCSHEHYVTLNLPCCPLSPPASPSPSVSSTTSQSSTFSS 1152

  Fly  1255 ----PEMMQHFTLSEQFCRQHFLSGLLLQELKSSLNEVGH----VRRHALGIFKDLLAKHELDNR 1311
                |:::..|.||..|.:|||||||||.||..:|:....    :.:.|:....:||..|::|:|
  Rat  1153 QAPDPKVISMFELSGPFRQQHFLSGLLLTELALALDPEAEGASLLHKKAITAVHNLLCSHDVDSR 1217

  Fly  1312 YQQKGQLSRIALLYVPWLGVVMDNIHRIDDLSESGACTPNGHVYADSASYTKRLSCSSSYVFSKD 1376
            |......:::|.||:|.|.:..|.:.|:             |.:|:.:....||:.      ..|
  Rat  1218 YTDATVKAKVAELYLPLLSLARDTLPRL-------------HGFAEGSGQRSRLAS------MLD 1263

  Fly  1377 SSTFGSLTSTPRSKNRLTMHCDQASPYRTSVHMKEHNYLAAIAGQPISNGISNLSLNSNTDSGHS 1441
            |.|.|              ..|.......||.|       ||||.|::.| |..|::    .|.|
  Rat  1264 SDTEG--------------EGDIGGTINPSVAM-------AIAGGPLAPG-SRTSIS----QGPS 1302

  Fly  1442 QDTTTIGAYTNGDTDVALRNGHNRSVSVTHAQILSRCDKFSSVESKDLLLGFLFIIKHLSQEQMI 1506
            .........|.     |.|:|               | ..|:..|:.||:..|:::|:.....:.
  Rat  1303 TKWILFPLCTQ-----AARSG---------------C-PLSAESSRTLLVCVLWVLKNAEPALLQ 1346

  Fly  1507 GWWQNCNESETLQFLSILDLCLLQFRYVGKKSVV-ITTET------RQGRLAKA--NTLPARTQP 1562
            .|..:....:..:.|.:|.|||..|.|.|||:.. |.:.|      .:.||.:|  .|:.||.:
  Rat  1347 RWAADLALPQLGRLLDLLYLCLAAFEYKGKKAFERINSLTFKKSLDMKARLEEAILGTIGARQE- 1410

  Fly  1563 PTGLENGSQEQQPSSGTLN-----------QTREHLLEDIDTLARNQLALYESNLATEVGMIILD 1616
               :...|:|:.|.....|           ||.:.:.:..|.:...  ||.:.|||||..:::||
  Rat  1411 ---MVRRSRERSPFGNQENVRWRKSVTHWRQTSDRVDKTKDEVEHE--ALVDGNLATEASLVVLD 1470

  Fly  1617 CLGLYVLQFRQLLADSLVLPKVARVYLRFLQLGQSERLSKHVFAALRAFINNYAVALFKGNAMLC 1681
            .|.:.|.......|...:|..|.:|.|..|...||....:|..|..||.::.:...||:.:..||
  Rat  1471 MLEIIVQTVMLSEARESILGAVLKVVLYSLGSAQSALFLQHGLATQRALVSKFPELLFEEDTELC 1535

  Fly  1682 GQMVYELLKACDSRLVEIRHESCAVLYLLMRSNFEFSGRKALTRVHLQVIISVSQMIGNVIGLNN 1746
            ..:...||:.|.||:..||..:.|.||||||.|||.....|  ||.:.|.:|:|.::|.....:.
  Rat  1536 ADLCLRLLRHCGSRISTIRTHASASLYLLMRQNFEIGHNFA--RVKMLVTMSLSSLVGTTQNFSE 1598

  Fly  1747 ARFQESLSIINSYANSDKAMKGTGFPMEVKDLTRRVRTVLMATAQMQAHHMDPERLLELQYSLAN 1811
            ...:.||..|.:||..|..::.:.|..:|:||...:..:|..|.:|:.|..|||.|::|.|.:|.
  Rat  1599 EHLRRSLKTILTYAEEDLGLRDSTFAEQVQDLMFNLHMILTDTVKMKEHQEDPEMLMDLMYRIAR 1663

  Fly  1812 SYASTPELRHTWLVTMARNHEQNGNLSEAACCHLHIAALMCEYL-------RLKGGCTLSWSSTA 1869
            .|..:|:||.|||..||..|.:.||.:|||.|.:|.|||:.|||       .|..||      .:
  Rat  1664 GYQGSPDLRLTWLQNMASKHAELGNHAEAAQCMVHAAALVAEYLALLEDSRHLPVGC------VS 1722

  Fly  1870 FGKISTNIPLDEQGLKLDAGAQDSQ-------YTEQMLLEQLKLCADFLDRAERFECLGELYKLI 1927
            |..:|:|: |:|..:..|..:.|.:       :|:..|:..|:..|.:......:|.:.|:||.:
  Rat  1723 FQNVSSNV-LEESAISDDILSPDEEGFCSGKNFTDLGLVGLLEQAAAYFTMGGLYEAVNEVYKNL 1786

  Fly  1928 LPMYERDRSYQDLAHCYEHLTQAYNKIVEVNRSGKRMLGRFYRVVFYGLMYFEEDHAIEFVYKEP 1992
            :|:.|..|.|:.||..:..|.:|:.||:..:...:|:.|.::||.|||..:.:.|.. |||||||
  Rat  1787 IPILEAHRDYKKLAAVHGKLQEAFTKIMHQSSGWERVFGTYFRVGFYGARFGDLDEQ-EFVYKEP 1850

  Fly  1993 KLTSLSEISERLAKQYKEKFGADVVKMIMDSSPVKVDELDAKLAYIQVTHVIPFFSKDELDQRLN 2057
            .:|.|:|||.||.:.|.|:||.|||::|.||:||...:||.:.||||:|:|.|.|...||..|:.
  Rat  1851 SITKLAEISHRLEEFYTERFGDDVVEIIKDSNPVDKLKLDPQKAYIQITYVEPHFDTYELKDRVT 1915

  Fly  2058 EFEQNHDVDTFMYETPFTKSGAARGSVEEQWKRKTVIKTQYSFPYVLKRIPVKSREIIELSPIEV 2122
            .|::|:.:..|::.||||..|.|.|.:.||.||||::.|:::|||:..||.|..||...|:|:||
  Rat  1916 YFDRNYGLRAFLFCTPFTPDGRAHGELAEQHKRKTLLSTEHAFPYIKTRIRVCHREETVLTPVEV 1980

  Fly  2123 AIDEMQSKVSEL----EEIILPPADVKKLQLRLQGSVAVTVNAGPLAYAHAFL-----DAKVVNN 2178
            ||::||.|..||    |:   .|.|.|.||:.|||||..|||.|||..|..||     |.|:..:
  Rat  1981 AIEDMQKKTRELAFATEQ---DPPDAKMLQMVLQGSVGPTVNQGPLEVAQVFLSEIPEDPKLFRH 2042

  Fly  2179 FSMDRVGDLKDVFRDFIVVCQKALFLNERIISADQKEYHHVLKENYEKLCQALSELLDDESFQPL 2243
            .:     .|:..|:||...|:.||..|:.:|..||||||..|:.:|.:|.:||..||.....|.|
  Rat  2043 HN-----KLRLCFKDFCKKCEDALRKNKALIGPDQKEYHRELERHYSRLREALQPLLTQRLPQLL 2102

  Fly  2244 GDDADSINQRNSM 2256
            ...:.|:  |||:
  Rat  2103 APSSTSL--RNSI 2113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ziz	NP_001260200.1	DOCK_C-D_N	37..>81	CDD:463380	13/43 (30%)
		PH_DOCK-D	278..405	CDD:270087	17/128 (13%)
		C2_Dock-D	793..981	CDD:176079	65/192 (34%)
		DHR2_DOCK_D	1818..2231	CDD:212567	172/435 (40%)
Dock6	XP_038937778.1	DOCK_C-D_N	48..157	CDD:463380	31/238 (13%)
		C2_Dock-C	547..724	CDD:176078	65/192 (34%)
		DHR2_DOCK	1668..2090	CDD:471388	173/437 (40%)