Protein Alignment Ziz and Zir

DIOPT Version :10

• Sequence 1: NP_001260200.1
• Gene: Ziz / 34030
• FlyBaseID: FBgn0260486
• Length: 2298
• Species: Drosophila melanogaster
• Sequence 2: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Alignment Length: 2518
• Identity: 686/2518 - (27%)
• Similarity: 1046/2518 - (41%)
• Gaps: 726/2518 - (28%)

  Fly     2 ERKFTRGLNKLGSAVQMRENVSQLVRESAVLNKPL----------VVEPIDFEAFIAKNKTVIQN 56
            :|.|.:.::| .||..:|:|||     ...|:|.:          ..||:|:|.|::::..:|..
  Fly     5 QRSFVQKVSK-QSAADVRKNVS-----GCHLSKAMDPSLCGSSISPTEPLDYEEFLSQHMNIINR 63

  Fly    57 DPQRELLIYPTDDVSEIIMPRKQRTNAKSVADRFDPPNEAIVCPLHGPSMITNGNGHSQVSRQGS 121
            ||.:.:|.:|..||:..|:|||.||
  Fly    64 DPLKHILDFPQGDVTVKIIPRKIRT---------------------------------------- 88

  Fly   122 IQSNGSHHNGNGNGHTSSSSSSSLNNSNGHGQLSRKSSQCSNGSSSQKDSSYESALSSITLRSNL 186
                                                                             
  Fly    89 ----------------------------------------------------------------- 88

  Fly   187 AQPEEVDEFADDGNAEDLVDGQPHGSRAECTR-FTRQALYTYRAKNHLIHYKYNAYGGNCH---- 246
                 ||....:.|..||    ||..: ||.. :||.......|:.||        ..:|:
  Fly    89 -----VDHVVPNENLSDL----PHHVQ-ECVNCYTRPWKVVEYAQRHL--------SSSCYIRER 135

  Fly   247 -DLPSISPAEELVEEIYEIDADQDRIDEQMT-RSQADTITKQGYLLKGPDSASDRMFANIGNKSF 309
             |..:|||:  ..::.:|||.|....:|... :|::.|          |.|
  Fly   136 IDRGTISPS--AYQQEFEIDKDFSSFEEAFAYKSESCT----------PSS-------------- 174

  Fly   310 KRRYCYLRQEIDGTYILELHKDEKQGEAKATIV-MDFCTDVVQNPKRGRFCFELRMTTGHKSFTL 373
                   ||.|                  |::. :..|||.: .|:.....|:||.:.
  Fly   175 -------RQSI------------------ASLASVSSCTDTL-TPRGSWASFDLRRSV------- 206

  Fly   374 AAENEQDFKDWLSKISSVLAQNRAQEEKRNASLERHPSIGSNPSPQLQPPAMD--PPTFGTLKGL 436
                                                    ::|   |.|..:|  ||     :.:
  Fly   207 ----------------------------------------NDP---LIPNLLDNVPP-----EHI 223

  Fly   437 DQSLHPQLMKYGRETDHSIALARREQRRR--LFACYQSPVKGSGSDNVEQYR------EHFGTRL 493
            |||..                |||:|.|:  ||:.|.   :....:|:|:..      ||.|.|:
  Fly   224 DQSNE----------------ARRQQDRQMALFSLYP---ESEAEENIERRLLAEIPVEHMGHRI 269

  Fly   494 LLTCHNLRFRLQCIPQDESSAGGVEQQVEPYITSLALFDAKANRKLSENFYFNVNEQWAAQLLPN 558
            .:.|..||               :|.:|||...|:|::|||..:|:||||||::|.....::|
  Fly   270 QVNCLQLR---------------LELEVEPIFASMAIYDAKERQKISENFYFDMNADSLKRML-- 317

  Fly   559 TPVPSSVAGCGVPRKSAEGDERSTACQAPHSLFDGVSAELLRSNRQQFQQLRQCLLSVTAPHADI 623
                ||...|.         :.||                         |....:..::.|..|:
  Fly   318 ----SSHVQCA---------DIST-------------------------QSHSAIFEISYPSNDL 344

  Fly   624 YLVVRIEKILQSGIAQVTEPYLKAGKDPKLGQKVYKAAKSYAQHIGHYRQPFAW----------- 677
            :||:|:||:||..|....|||||..|| |..:||...|..|.:.:|.||.||||
  Fly   345 FLVIRLEKVLQGDINNSVEPYLKEDKD-KYREKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNG 408

  Fly   678 ----------AARPLF----------KQYSHELD---------------------------VDPK 695
                      |.|..|          ...|:.||                           ::.|
  Fly   409 DNFESKDAGAAERDSFGNACGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERK 473

  Fly   696 REF-------------EFSPI-------YRQEIPKLKDEELLKLLVDYRKPEK-LSKLTIIPGSL 739
            .:.             .|.||       ::||..|:|||:|.|:|.:.::|.. :.|...||||:
  Fly   474 EKHRSWSPDDFANVVENFRPITITVPSFFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSI 538

  Fly   740 KMQMQFLDQTTPC------GLSKSLAPLSTFSPSSKQS--PTVEVAEFQSQSERDAHPYTSFCNH 796
            |:::      :||      .|:..|||:   :|.|..:  |..|:.||...:  ..:|:.|:.|.
  Fly   539 KLEI------SPCVEEAKNALTPELAPI---NPQSADNVRPVKEILEFPQSA--IYNPHYSYRNL 592

  Fly   797 LYVYPLSLQFDSQKLFSRARNITVVVELRDGDGEYSKPLKCIYGRPGQDLLVSQIACPVLHHNVT 861
            |:|.|..|.|.|:.  ..||||.|.|:|..|:.. ...:..|||:.......::....|.:||..
  Fly   593 LFVSPKELNFSSRA--GSARNIAVRVQLMAGETP-KDAVNAIYGKSSCPKFSTEAFTAVNYHNKC 654

  Fly   862 PTWYEEIKLRLPLGLFPEHHLLFSFYHVSCNLSKKRDANAAFETPIGYAWLPLLQKNRICLEEQQ 926
            |::|:|||:.||..:...|||||:.|||||. .|.:|...:.||||||.|||||:..::...|..
  Fly   655 PSFYDEIKIALPASIKQHHHLLFTIYHVSCQ-KKPQDLQPSVETPIGYTWLPLLEDGKLKFGEFN 718

  Fly   927 LPV-AATLPVGYLSIQPLGWGKGNCG-PDIQWIDNQRNLYTVGLRLDSTVLTADQHLHNFFGHCE 989
            ||| ..:.|..|..|.|      |.. |.|:|:||.|.::::.:...:.:.|.|..|..||..||
  Fly   719 LPVMVESPPENYSFIPP------NVHLPGIKWLDNHRAVFSINVEAVTAIHTLDSFLDRFFLICE 777

  Fly   990 RLLEGGKTGAVPA-------ETETCKILKAAHAIDMKSLINYLPTVLNELFTLLVHT-----QSE 1042
            .|    .|..:|:       |||..|.|......:.:.|:.:||.||::|..|||.|     |:.
  Fly   778 YL----DTRNIPSHIGENNIETELKKCLLDIEYANREPLVRHLPLVLDKLIELLVVTHKVGGQAM 838

  Fly  1043 EIGLNVIRLITNIIHLIS-------DQAKRSDLLGAYVKY---VFHAPYYSQQ------------ 1085
            .:|..|..::..:..|:|       ||..|..||..||.:   :.| |:.|:|
  Fly   839 SLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYVHFQCKIPH-PFQSKQRLTCSRSTTEDL 902

  Fly  1086 --------------------------------TARQ---RTVHGELCRHLPYLLNPSNPDFLIVN 1115
                                            .||.   |.:|.||..|. .:.:....|..:.|
  Fly   903 QLSESYTIYDNVLASGRSLDRKELSIDVLHSMAARDVQVRLLHEELALHW-VVASGKAADLAMSN 966

  Fly  1116 KFMRYSSIFFDLIIKSMAQHLLATGRIRMLRNERFPKEYGDRVEQLIKALMPYITTRFEDL-SEE 1179
                 |...|:||:|||.:||..:..:...|..|||.::.|.:..|:.    .:||:.... |.|
  Fly   967 -----SWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVH----LVTTKVVGYHSNE 1022

  Fly  1180 THL---LNRSLAKFVRQCLSYMDRGFVFRLIRCYMGEFSPGNPRI--LHEYKFNFLQEICQHEHY 1239
            ..|   ||.||..|:...||.|||||||.||:.|.......|..|  |..||.:||:.:|.|||:
  Fly  1023 PKLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHEHF 1087

  Fly  1240 VPLNLPF------VLNPKNRPP--------------EMMQHFTLSEQFCRQHFLSGLLLQELKSS 1284
            |.|||||      |..|.:..|              |...|..||::|.:||||.||:|.:| ::
  Fly  1088 VALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLERALHADLSQEFLQQHFLVGLVLSDL-AA 1151

  Fly  1285 LNEVGHVRRH--ALGIFKDLLAKHELDNRYQQKGQLSRIALLYVPWLGVVMDNIHRIDDLSESGA 1347
            :.||.:.:.|  |:...::|:..|:||.||.:....:|:|.||:|.|.:|||
  Fly  1152 VMEVPNPQLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIPLLSIVMD------------- 1203

  Fly  1348 CTPNGHVYADSASYTKRLSCSSSYVFSKDSSTFGSLTSTPRSKNRLTMHCDQASPYRTSVHMKEH 1412
            |.|..|.:.......:::               |.|.             |...|::|
  Fly  1204 CIPQLHQHGLEQDRLQQI---------------GQLE-------------DYQGPHQT------- 1233

  Fly  1413 NYLAAIAGQPISNGISNLSLNSNTDSGHSQDTTTIGAYTNGDTDVALRNGHNRSVSVTHAQILSR 1477
                          |:..::|                     .:||.....:|..|..:.|:.::
  Fly  1234 --------------ITASTIN---------------------PEVAFAISGSRPYSYLNEQVKNK 1263

  Fly  1478 CDKFSSVESKDLLLGFLFIIKHLSQEQMIGWWQNCNESETLQFLSILDLCLLQFRYVGKKSVVIT 1542
            . ..||..::.||:.||:::|:|.:..:..|..:.:.....|.|..:::||..|.|.|:|:|
  Fly  1264 L-PLSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNV--- 1324

  Fly  1543 TETRQGRLAKANTLPARTQPPTGLENGSQEQQPSSGTLNQTREHLL------------------- 1588
                 ..|.:.||...|....|.::...:|  ...|| |..|..|:
  Fly  1325 -----ATLKRTNTQSFRKTGSTDVKEKLEE--CIRGT-NSARYDLINRRKDRNSTEKFRWRKDQM 1381

  Fly  1589 ----EDIDTLARNQLAL-----YESNLATEVGMIILDCLGLYVLQFRQLLADSLVLPKVARVYLR 1644
                :..|.:.:::..|     .|.:|||||.:::||.|.:.|.....|..:  :|..|.:|.|.
  Fly  1382 PYRSQYADAVGKSEHELELSHFIEGSLATEVALVLLDTLEIIVHAAANLYHN--LLGTVLKVLLH 1444

  Fly  1645 FLQLGQSERLSKHVFAALRAFINNYAVALFKGNAMLCGQMVYELLKACDSRLVEIRHESCAVLYL 1709
            .|...||....:::||:.||.|..:...||.....:|..:...|||.|.|.|..||.::.|.|||
  Fly  1445 SLSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYL 1509

  Fly  1710 LMRSNFEFSGRKALTRVHLQVIISVSQMIGNVIGLNNARFQESLSIINSYANSDKAMKGTGFPME 1774
            |||.|||.....|  ||.:||.:|:|.::|.....:....:.:|..:..||.||..::.|.||.:
  Fly  1510 LMRQNFEIGNNFA--RVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQ 1572

  Fly  1775 VKDLTRRVRTVLMATAQMQAHHMDPERLLELQYSLANSYASTPELRHTWLVTMARNHEQNGNLSE 1839
            |:||...:..:|..|.:|:.:..|||.||:|...:|..|.:.|:||.|||..||:.|.:..|.:|
  Fly  1573 VQDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTE 1637

  Fly  1840 AACCHLHIAALMCEYL-RLKGGCTLSWSSTAFGKISTNIPLD-----------EQGLKLDAGAQD 1892
            ||.|::|.|:|:.||| .|:....|...:.:|.:||.|..::           |.|:.|     .
  Fly  1638 AAMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICL-----G 1697

  Fly  1893 SQYTEQMLLEQLKLCADFLDRAERFECLGELYKLILPMYERDRSYQDLAHCYEHLTQAYNKIVEV 1957
            :.:||..|...|:..::....|..:|.:.|:||:::|:.|.:|.:|.|:..:..|.:|:|:|.::
  Fly  1698 NHFTETGLKALLEEASNSFQVAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAFNRISQL 1762

  Fly  1958 NRSGKRMLGRFYRVVFYGLMYFEEDHAIEFVYKEPKLTSLSEISERLAKQYKEKFGADVVKMIMD 2022
              .|||:.|.::||.|||..:.:.|.. ||:||||.||.|.||..||...|.|:||.|.|.:|.|
  Fly  1763 --QGKRVFGTYFRVGFYGGKFGDLDQQ-EFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKD 1824

  Fly  2023 SSPVKVDELDAKLAYIQVTHVIPFFSKDELDQRLNEFEQNHDVDTFMYETPFTKSGAARGSVEEQ 2087
            |:.|.::.||...||||:|:|.|:|...|:..|...||:|.::..|:|.|||||:|.|.|.:.||
  Fly  1825 SNTVDINSLDPDKAYIQITYVEPYFETYEMRHRETYFERNFNIKRFIYATPFTKNGKAHGELNEQ 1889

  Fly  2088 WKRKTVIKTQYSFPYVLKRIPVKSREIIELSPIEVAIDEMQSKVSEL-----EEIILPPADVKKL 2147
            .||||::.|...||||..||.|.||:.|.|.||||||:::|.|..||     :|    |||.|.|
  Fly  1890 CKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQE----PADPKIL 1950

  Fly  2148 QLRLQGSVAVTVNAGPLAYAHAFL----DAKVVNNFSMDRVGDLKDVFRDFIVVCQKALFLNERI 2208
            |:.|||.:..|||.||:..|..||    |...|.....::   |:..||:|...|..||..|..:
  Fly  1951 QMVLQGCIGTTVNQGPMEMASVFLSNLSDGTTVPTKHQNK---LRLCFREFSKRCADALKKNRNL 2012

  Fly  2209 ISADQKEYHHVLKENYEKLCQALSELLDDESFQPLG-DDADSINQRNS 2255
            |.:|||:|...|:.|.::..:.|:..:...|.|..| ..|::.|.:::
  Fly  2013 ILSDQKDYQRELERNNDRFIERLTPFITLTSVQNHGVVKANAYNNKST 2060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ziz	NP_001260200.1	DOCK_C-D_N	37..>81	CDD:463380	16/43 (37%)
		PH_DOCK-D	278..405	CDD:270087	15/127 (12%)
		C2_Dock-D	793..981	CDD:176079	68/189 (36%)
		DHR2_DOCK_D	1818..2231	CDD:212567	167/433 (39%)
Zir	NP_608489.2	DOCK_C-D_N	46..153	CDD:463380	38/231 (16%)
		C2_Dock-C	589..769	CDD:176078	68/189 (36%)
		DHR2_DOCK_C	1614..2035	CDD:212568	168/435 (39%)