|
Fly 3 RKFTRGLNKLGSAVQMRENVSQLVRESAVLNKPLVVEPIDFEAFIAKNKTVIQNDPQRELLIYPT 67
||||:.|:|.|:|.::|::||:.||.|.||.|..:|||:|:|..|.:.||.|.:||.|:||::|.
Rat 5 RKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKLVEPLDYENVITQRKTQIYSDPLRDLLMFPM 69
Fly 68 DDVSEIIMPRKQRTNAKSVADRFDPPNEAIVCPLHGPSMITNGNGHSQVSRQGSIQSNGSHHNGN 132
:|:|..::.|:.||...:|
Rat 70 EDISLSVIGRQLRTVQSTV---------------------------------------------- 88
Fly 133 GNGHTSSSSSSSLNNSNGHGQLSRKSSQCSNGSSSQKDSSYESALSSITLRSNLAQPEEVDEFAD 197
||:.::
Rat 89 --------------------------------------------------------PEDAEK--- 94
Fly 198 DGNAEDLVDGQPHGSRAECTRFTRQALYTYRAKNHLIHYKYNAYGGNCHDLP--SISPAEELVEE 260
||: :.|.::.:.||....|:::|||..:.|:...|| |:.| |::...
Rat 95 ---------------RAQ-SLFVKECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRP-EKIPNH 142
Fly 261 IYEIDADQDRIDEQMTR--SQADTITKQGYLLKGPDSASDRMFANIGN------KSFKRRYCYLR 317
::|||.|.:: ||..:. ||...:.|||:|.| ||:.: |.|||||.||.
Rat 143 VFEIDEDCEK-DEDSSSLCSQKGGVIKQGWLHK----------ANVNSTITVTMKVFKRRYFYLT 196
Fly 318 QEIDGTYILELHKDEKQG-EAKATIVMDFCTDVVQNPKRGRFCFELRMTTGHKSFTLAAENEQDF 381
|..||:|||..:||||.. |:|..|.:|.|.||||.||..|..|||:|...:..: ||||.||:.
Rat 197 QLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHY-LAAETEQEM 260
Fly 382 KDW---LSKISSVLAQNRAQEEKRNASLERHPSIGSNPSPQLQPPAMDPPTFGTLKGLDQSLHPQ 443
::| |.||..:...:..||:|......:.....|....: ..:..|::|:||:
Rat 261 EEWLITLKKIIQINTDSLVQEKKETVEAIQEEETSSQGKAE-----------NIMASLERSMHPE 314
Fly 444 LMKYGRETDHSIALARREQRRRLFACYQSPVKG---SGSD-NVEQYREHFGTRLLLTCHNLRFRL 504
||||||||:....|:|.:.|:.||: :.|.|:. ||.: :|:.:.|....|.|:.||:|.|.:
Rat 315 LMKYGRETEQLNKLSRGDGRQNLFS-FDSEVQRLDFSGIEPDVKPFEEKCNKRFLVNCHDLTFNI 378
Fly 505 QCIPQDESSAGGVEQQVEPYITSLALFDAKANRKLSENFYFNVNEQWAAQLLPNTPVPSSVAGCG 569
:.....:|.|....|||:..:|||||.|.|.|:|.:|:.::|.....::| .|
Rat 379 --LGHIGDNAKGPPTNVEPFFITLALFDVKNNCKISADFHVDLNPPSVREML-----------WG 430
Fly 570 VPRKSAEGDERSTACQAPHSLFDGVSAELLRSNRQQFQQLRQCLLSVTAPHADIYLVVRIEKILQ 634
:..:.| ::.:|...:|.||..|:: ..:...:||.:.|||.||.:|:|||||||:||
Rat 431 MSTQLA--NDGNTKGSSPESLIHGIA-------ESRLCYIRQGIFSVTNPHPEIFLVVRIEKVLQ 486
Fly 635 SGIAQVTEPYLKAGKDPKLGQKVYKAAKSYAQHIGHYRQPFAWAARPLFKQYSHELDVDPKREFE 699
..|....|||:|.....|..|||::.||.....:|.||.||||||||:||.....||:|.|
Rat 487 GNITHCAEPYIKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDLQGSLDLDGK---- 547
Fly 700 FSPIYRQEIPKLKDEELLKLLVDYRKPEKLSKLTIIPGSLKMQMQFLDQTTPCGLSKSLAPLSTF 764
|||:|:|:..||.:|::||||.:|:|||| :||.||||.|.:.::.:....|..::.|..||..|
Rat 548 FSPLYKQDSSKLSNEDILKLLSEYKKPEK-TKLQIIPGQLNITVECVPVDLPNCITSSYVPLKPF 611
Fly 765 SPSSKQSPTVEVAEFQSQSERDAHPYTSFCNHLYVYPLSLQFDSQKLFSRARNITVVVELRDGDG 829
..:. |:.||||.||..:..:..:|:|.:.||||||||.|::||||.|::||||.|.||.||.|.
Rat 612 EKNC-QNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFAKARNIAVCVEFRDSDE 675
Fly 830 EYSKPLKCIYGRPGQDLLVSQIACPVLHHNVTPTWYEEIKLRLPLGLFPEHHLLFSFYHVSCNL- 893
..:..||||||:|...:..:.....|.|||..|.:|:|||:.||:.|..:|||||:||||||.:
Rat 676 SDTSALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEIN 740
Fly 894 ----SKKRDANAAFETPIGYAWLPLLQKNRICLEEQQLPVAATLPVGYLSIQPLGWGKGNCGPDI 954
:||:| ..|||:|:||:|||:..|:...||||||:|.||.|||::.. ...:.....||
Rat 741 TKGTTKKQD---TVETPVGFAWVPLLKDGRVTTLEQQLPVSANLPPGYLNVND-AESRRQSNADI 801
Fly 955 QWIDNQRNLYTVGLRLDSTVLTADQHLHNFFGHCERLLEGGKTGAVPAETETCKILKAAHAIDMK 1019
:|:|..:.|..:...|:||:.|.|.|:|.||.||:.:..|.| .||. |..|.||..||::::
Rat 802 KWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSK--EVPG--ELIKYLKCLHAMEIQ 862
Fly 1020 SLINYLPTVLNELFTLLVH-TQSEEIGLNVIRLITNIIHLISDQAKRSDLLGAYVKYVFHAPYYS 1083
.:|.:||.:|.:||.:|.: |..:::.:|...::.:|:....::...| .|.:::||.|... .
Rat 863 VMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLES-YLRSFIKYSFRPE--K 924
Fly 1084 QQTARQRTVHGELCRHLPYLLNPSNPDFLIVNKFMRYSSIFFDLIIKSMAQHLLATGRIRMLRNE 1148
..|.:.:.:|..|...:..:|..| .|||.:||.::||..||::|.||||.:||...:|::.|.:
Rat 925 PSTLQAQLIHETLATTMIAILKQS-ADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQ 988
Fly 1149 RFPKEYGDRVEQLIKALMPYITTRFEDLSEETHLLNRSLAKFVRQCLSYMDRGFVFRLIRCYMGE 1213
|||:.|...:..|:.|::|::|.|:.::.:|:..:|.|||.|:::||:.|||||||.||..|:..
Rat 989 RFPEAYHHILHSLLLAIIPHVTIRYAEIPDESRNVNYSLASFLKRCLTLMDRGFVFNLINDYISG 1053
Fly 1214 FSPGNPRILHEYKFNFLQEICQHEHYVPLNLPFVL-NPK-NRPPEMMQ-------------HFTL 1263
|||.:|::|.||||.|||.||.||||:|||||... .|| .|..:... .::|
Rat 1054 FSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDFFSFAVDRLTSVDSNLEYSL 1118
Fly 1264 SEQFCRQHFLSGLLLQELKSSLNEVGHVRRHALGIFKDLLAKHELDNRYQQKGQLSRIALLYVPW 1328
|:::|:.|||.||||:|...:|.:...:|..|:.:.|:||.||..|.|||.|.|.::||.||:|:
Rat 1119 SDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPF 1183
Fly 1329 LGVVMDNIHRI--DDLSESGACTPNGHVYADSASYTKRLSCSSSYVFSKDSSTFGSLTSTPRSKN 1391
:|::::||.|: .|...|.|..|| || |:|....|.::.|.|.
Rat 1184 VGLLLENIQRLAGRDTLYSCAAMPN------SA--------------SRDEFPCGFVSPTSRG-- 1226
Fly 1392 RLTMHCDQASPYRTSVHMKEHNYLAAIAGQPISNGISNLSLNSNTDSGHSQDTTTIGAYTNGDTD 1456
::..| ||..|.:...|..|....|..||.....:|.....:|
Rat 1227 --SLATD-----------KEPAYGSFQNGHGIKREDSRGSLIPEGATGFPDPGST---------- 1268
Fly 1457 VALRNGHN--RSVSVTHAQILSRCDKFSSVESKDLLLGFLFIIKHLSQEQMIGWWQNCNESETLQ 1519
|.| :|.|.|.....:|.|:: |.::||:.:|:|:|.:|::.::.:|...:..|.:.
Rat 1269 -----GENTRQSSSRTSVSQYNRLDQY---EIRNLLMCYLYIVKMISEDTLLTYWNKVSPQELIN 1325
Fly 1520 FLSILDLCLLQFRYVGKKSVVITTETRQGRLAKANTLPARTQPPTGLENGSQEQQPSSGTLNQTR 1584
.|.:|::||..|||:||::: .......|:|...:..::|....|.| .||.:....
Rat 1326 ILVLLEVCLFHFRYMGKRNI---ARVHDAWLSKHFGIDRKSQTMPALRN-------RSGVMQARL 1380
Fly 1585 EHL--LEDIDTLARNQL---------ALYESNLATEVGMIILDCLGLYVLQFR-QLL---ADSLV 1634
:|| ||...||..:.. ||.|.|.||||.:.:||.:..:...|: ||| ..:.:
Rat 1381 QHLSSLESSFTLNHSSATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKSQLLNNDGHNPL 1445
Fly 1635 LPKVARVYLRFLQLGQSERLSKHVFAALRAFINNYAVALFKGNAMLCGQMVYELLKACDSRLVEI 1699
:.||..::|.||:.||||...|||||:||:||:.:..|.|||...:|....||:||.|.|::...
Rat 1446 MKKVFDIHLAFLKNGQSEVSLKHVFASLRSFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISST 1510
Fly 1700 RHESCAVLYLLMRSNFEFSGRKALTRVHLQVIISVSQMIGNVIGLNNARFQESLSIINSYANSDK 1764
|:|:.|:||||||:|||::.||...|.|||:||:|||:|.:|.....:||||||.|||::||||:
Rat 1511 RNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDR 1575
Fly 1765 AMKGTGFPMEVKDLTRRVRTVLMATAQMQAHHMDPERLLELQYSLANSYASTPELRHTWLVTMAR 1829
.||.|.||.||||||:|:||||||||||:.|..|||.|::||||||.|||||||||.|||.:||:
Rat 1576 PMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAK 1640
Fly 1830 NHEQNGNLSEAACCHLHIAALMCEYLRLK----GGCTLSWSSTAFGKISTNIPLDEQG-LKLDAG 1889
.|.:||:.||||.|::|:|||:.|:|..| .|| :||.||:.|| ||:| :|.|||
Rat 1641 IHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGC------SAFKKITPNI--DEEGAMKEDAG 1697
Fly 1890 AQDSQYTEQMLLEQLKLCADFLDRAERFECLGELYKLILPMYERDRSYQDLAHCYEHLTQAYNKI 1954
..|..|:|::|||.|:.|.|.|.:|||:|.:.|:.|||:|:||:.|.::.|...|..|..||.||
Rat 1698 MMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKI 1762
Fly 1955 VEVNRSGKRMLGRFYRVVFYGLMYFEEDHAIEFVYKEPKLTSLSEISERLAKQYKEKFGADVVKM 2019
:||..:.||:||.|:||.|||..:|||:...|::|||||||.|||||.||.|.|.||||.:.:|:
Rat 1763 LEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISFRLVKLYGEKFGTENIKI 1827
Fly 2020 IMDSSPVKVDELDAKLAYIQVTHVIPFFSKDELDQRLNEFEQNHDVDTFMYETPFTKSGAARGSV 2084
|.||..|...|||.|.|:||||:|.|:|...||.:|..|||:||:::.|::|.|:|.||..:|.:
Rat 1828 IQDSDKVNAKELDPKFAHIQVTYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCI 1892
Fly 2085 EEQWKRKTVIKTQYSFPYVLKRIPVKSREIIELSPIEVAIDEMQSKVSELEEIILPPADVK--KL 2147
|||.||:|::.|..|||||.||||:...:.:.|.||:||.||::.|.:||.: :...|||. :|
Rat 1893 EEQCKRRTILTTSNSFPYVKKRIPITCEQQVNLKPIDVATDEIKDKTAELHK-LCSSADVDMIQL 1956
Fly 2148 QLRLQGSVAVTVNAGPLAYAHAFLDAKVVNNFSMDRVGDLKDVFRDFIVVCQKALFLNERIISAD 2212
||:|||.|:|.|||||||||.|||:....|.:...:|.:|||:||.||..|..||.||||:|..|
Rat 1957 QLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKED 2021
Fly 2213 QKEYHHVLKENYEKLCQALSELLDDESFQPLGDDADSINQRNSMALFNAISGASHN 2268
|.|||..||.|:..:.:.||:::.::..|. |...|....|::.:|.||||.|.|
Rat 2022 QIEYHEGLKSNFRDMVKELSDIIHEQILQE--DTMHSPWMNNTLHVFCAISGTSSN 2075
| 
