Protein Alignment Ziz and Dock5

DIOPT Version :10

• Sequence 1: NP_001260200.1
• Gene: Ziz / 34030
• FlyBaseID: FBgn0260486
• Length: 2298
• Species: Drosophila melanogaster
• Sequence 2: NP_001358941.1
• Gene: Dock5 / 305987
• RGDID: 1306872
• Length: 1868
• Species: Rattus norvegicus
• Alignment Length: 1828
• Identity: 337/1828 - (18%)
• Similarity: 601/1828 - (32%)
• Gaps: 562/1828 - (30%)

  Fly   528 LALFDAKANRKLSENFYFNVNEQWAAQLLPNTPVPSSVAGCGVPRKSAEGDERSTACQAPHSLFD 592
            :||:|...:..:|||:..    :|.:.              |:|::.    |:....||..:  |
  Rat   243 IALYDPDQSTFISENYLI----RWGSN--------------GMPKEI----EKLNNLQAVFT--D 283

  Fly   593 GVSAELLRSNRQQFQQLRQCLLSVTAPHADIYLVVRIEKILQSGIAQVTEPYLKAGKDPKLGQKV 657
            ..|.:|:|.                          ||..:.|  |.:|....||.||
  Rat   284 LSSTDLIRP--------------------------RISLVCQ--IVRVGRMELKEGK-------- 312

  Fly   658 YKAAKSYAQHIGHYRQPFAWAARPL------------------FKQYSHELDVDPKREFEFSPIY 704
                    :|....|:||..|...:                  |:|.:.|..: .:|:...||:.
  Rat   313 --------KHTCGLRRPFGVAVMDISDIVHGKVDDEEKQHFIPFQQIAMETYI-RQRQLIMSPLI 368

  Fly   705 RQEIPKLKDEELLKLL--------VDYRKPEKLSKLTIIPGSL-KMQMQF---LDQTTPCGLSKS 757
            ...:.. ::|.|..:|        |:::.......|.::||.| ::|..|   :|::|  .:::.
  Rat   369 TSHVIG-ENEPLTSVLNKVIAAKEVNHKGQGLWVSLKLLPGDLTQVQKNFSHLVDRST--AIARK 430

  Fly   758 LAPLSTFSPSSKQSPTVEVAEFQSQSERDAHPYTSFCNHLYVYPLSLQFDSQKLFSRARNITVVV 822
            :.......|...:                        |.:||..:..:||..|. ...:|:.|.:
  Rat   431 MGFPEIILPGDVR------------------------NDIYVTLIHGEFDKGKK-KTPKNVEVTM 470

  Fly   823 ELRDGDGEYSKPLKCIYGRPGQDLLVSQIACPVLHHNVTPTWYEEIKLRLPLGLFPEHHLLFSFY 887
            .:.|.:|...:  |.|:...|.: .||:....|.:....|.|||.:|:.:.:......|:.|:|.
  Rat   471 SVFDEEGNLLE--KAIHPGAGYE-GVSEYKSVVYYQVKQPCWYETVKVFIAIEEVTRCHIRFTFR 532

  Fly   888 HVSCNLSKKRDANAAFETPIGYAWLPLLQKNRICLEE---------------QQLPVAATLP--V 935
            |.|...|:.:.     |...|.|::.|:..:...|::               :......|||  .
  Rat   533 HRSSQESRDKS-----ERAFGVAFVKLMNADGTTLQDGRHDLVVYKGDNKKMEDAKYYLTLPGTK 592

  Fly   936 GYLSIQPLGWGKGNCGPDI--QWIDNQRNLYTVGLRLDSTVLTADQHL----------HNFFGHC 988
            ..|..:.|...|   .|.:  ...|:.::.:.:...:.||.||.:..|          .|...:.
  Rat   593 AELEEKELQASK---NPSVFTPSKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNL 654

  Fly   989 ERLLEGGKTGAVPAETETCKILKAAHAIDMKSLINYLPTVLNELFTLLVH-TQSEEIGLNVIRLI 1052
            ::|:|                      :|...::.:|...|:.||.:::. :.:|.....|...:
  Rat   655 KKLME----------------------VDGGEIVKFLQDTLDALFNIMMEMSDNETYDFLVFDAL 697

  Fly  1053 TNIIHLISDQAKRSDLLGAYVKYVFHAPY---YSQQTARQRTVHGELCRHLPYLL----NPSNPD 1110
            ..||.||.|           :|:....|.   |..:.......|.:|.:.|.:.:    :||..:
  Rat   698 VFIISLIGD-----------IKFQHFNPVLETYIYKHFSATLAHVKLSKVLNFYVANAEDPSKTE 751

  Fly  1111 FLIVN-KFMRYSSIFFDLIIKSMAQHLLATGRIRMLRNERFPKEYGDRVEQLIKALMPYITTRFE 1174
            .|... |.::|   .|..||:|...:|...|:          .|.||.....|:.|.....|
  Rat   752 LLFAALKALKY---LFRFIIQSRVLYLRFYGQ----------SEDGDEFNNSIRQLFLAFNT--- 800

  Fly  1175 DLSEETHLLNRSLAKFVR---QCLSYMDRGFVFRLIRCYMGEFSPGNPRILHEYKFNF----LQE 1232
                   |::|.|.:.|:   ..|.|:                    |.|:::.|..|    |..
  Rat   801 -------LMDRPLEEAVKIKGAALKYL--------------------PSIINDVKLVFDPMELSV 838

  Fly  1233 I-CQHEHYVPLNLPFVLNPKNRPPEMMQHFTLSEQFCRQHFLSGLLLQELKSSLNEVGHVRRHAL 1296
            : |:....:|.| ..|....|...::::.....:..||:..|. ||..:|...|::
  Rat   839 LFCKFIQSIPDN-QLVRQKLNCMTKIVESSLFQQAECREVLLP-LLTDQLSGQLDD--------- 892

  Fly  1297 GIFKDLLAKHELDNRYQQKGQLSRIALLYVPWLGVVMDNIHRIDDLSESGACTPNGHVYADSASY 1361
                     |.....::...||              :.||..:.|.::.|  ..:.||.......
  Rat   893 ---------HSTKPDHEASSQL--------------LSNILEVLDRTDVG--PTSAHVQMIMERL 932

  Fly  1362 TKRLSCSSSYVFSKDSSTFGSLTSTPRSKNRLTMHCDQASPYRTSVHMKEHNYLAAIAGQPISNG 1426
            .:|:                         ||..:...:.||:
  Rat   933 LRRI-------------------------NRTVIGMSRQSPH----------------------- 949

  Fly  1427 ISNLSLNSNTDSGHSQDTTTIGAYTNGDTDVALRNGHNRSVSVTHAQILSRCDKFSSVESKDLLL 1491
                                ||::      ||......|.:..:|..:.     .|:.:::..::
  Rat   950 --------------------IGSF------VACMIAVLRQMEDSHYSLY-----ISTFKTRQDII 983

  Fly  1492 GFL---FIIKHLSQEQMIGW------WQNCNESETLQFLSILDLCLLQFRYVGKKSVVITTETRQ 1547
            .||   ||:    .:.:||.      |...|.:::..||..::    ||..|..||.
  Rat   984 DFLMETFIM----FKDLIGKNVYAKDWMVMNMTQSRVFLRAIN----QFAEVLTKSF-------- 1032

  Fly  1548 GRLAKANTLPARTQPPTGLENGSQEQQPSSGTLN-----QTREHL-LEDIDTLARNQLALYESNL 1606
                              ::..|.|.|..:...:     .|.|.| ||......||::.....::
  Rat  1033 ------------------MDQTSFELQLWNNYFHLAVAFLTHESLQLETFSEAKRNKIVKKYGDM 1079

  Fly  1607 ATEVGMIILDC---LGLYVLQFRQLLADSLVLPKVARVYLRFLQLGQSERLSKHVFAALRAFINN 1668
            ..|:|..|.|.   ||.:.::|         :|
  Rat  1080 RKEIGFRIRDMWYNLGPHKIKF---------IP-------------------------------- 1103

  Fly  1669 YAVALFKGNAMLCGQMVYELLKACDSRLVEIRHESCAVLYLLMRSNFEFSGRKALTRVHLQVIIS 1733
                          .||..:|:...:..||:|..:..:.:.:|:..|..||.........::|..
  Rat  1104 --------------SMVGPILEVTLTPEVELRKATIPIFFDMMQCEFNLSGNGNFHMFENELITK 1154

  Fly  1734 VSQMIGNVIGLNNARFQESL-SIINSYANSDKAMKGTG--FPMEVKDLTRRV---RTVLMATAQM 1792
            :.|.:..  |..:.:::..| .::..:....|.:..:|  |.:.|..|...:   ||::|
  Rat  1155 LDQEVEG--GRGDEQYKVLLEKLLLEHCRKHKYLSSSGEVFALLVSSLLENLLDYRTIIM----- 1212

  Fly  1793 QAHHMDPERLLELQYSLANSY--ASTPELRHTWLVTMARNHEQNGNLSEAACCHLHIAALMCEYL 1855
              |....|..:....::.|.|  ....::...:|..:...|....|.:|||            |.
  Rat  1213 --HDESKENRMSCTVNVLNFYKEKKREDIYIRYLYKLRDLHRDCENYTEAA------------YT 1263

  Fly  1856 RLKGGCTLSWSSTAFGKISTNIPLDEQGLKLDAGAQDSQ--YTEQMLLEQL-KLCADFLDRAERF 1917
            .|.....|.||..         |.....|:     :||.  ||:|.|.|:| :....:.|:.:.:
  Rat  1264 LLLHAELLQWSDK---------PCMPHLLQ-----RDSYYVYTQQELKEKLYQEIISYFDKGKMW 1314

  Fly  1918 ECLGELYKLILPMYE-RDRSYQDLAHCYEHLTQAYNKIVEVNRSGKRMLGRFYRVVFYGLMYFEE 1981
            |...:|.|.:...|| :...|:.|....:.....|..|::..|...    .::.|.:||..:...
  Rat  1315 EKAIKLSKELAETYESKVFDYEGLGSLLKKRALFYENIIKAMRPQP----EYFAVGYYGQGFPSF 1375

  Fly  1982 DHAIEFVYKEPKLTSLSEISERLAKQYKEKFGADVVKMIMDSSPVKVDELDAKLAYIQVTHVIPF 2046
            .....|:|:..:.....:.|.||..|:..      .:.:..::|...|...:...|:|...|.|.
  Rat  1376 LRNKIFIYRGKEYERREDFSLRLLTQFPN------AEKMTSTTPPGEDIRSSPKQYLQCFTVKPV 1434

  Fly  2047 FS-----KDE--LDQRLNEFEQNHDVDTFMYETPFTKSGA-ARGSVEEQWKRKTVIKTQYSFPYV 2103
            .|     ||:  .:|.||.:..| :|..|.|..||.|... ........|..:|...|.|:||.:
  Rat  1435 MSLPPSYKDKPVPEQILNYYRAN-EVQQFRYSRPFRKGEKDPENEFATMWIERTTYTTAYTFPGI 1498

  Fly  2104 LKRIPVKSREIIELSPIEVAIDEMQSKVSELEEIILPPA-----DVKKLQLRLQGSVAVTVNAGP 2163
            ||...||.....|:||:|.||:.|:.....:...:...|     .|..|.:.|.|.|...|..|.
  Rat  1499 LKWFEVKHISTEEISPLENAIETMELTNERVSNCVQQHAWDHSLSVHPLSMLLNGIVDPAVMGGF 1563

  Fly  2164 LAYAHAFLDAKVVNNFSMD--RVGDLKDVFRDFIVVCQKALFLNERIISADQKEYH-------HV 2219
            ..|..||...|.:.....|  :|..||.:....|.:..:.:.::...::...|..|       ..
  Rat  1564 SNYEKAFFTEKYLQAHPEDQEKVELLKRLIALQIPLLAEGIRIHGEKLTEQLKPLHDRLSSCFRE 1628

  Fly  2220 LKENYEKL 2227
            |||..|||
  Rat  1629 LKEKVEKL 1636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ziz	NP_001260200.1	DOCK_C-D_N	37..>81	CDD:463380
		PH_DOCK-D	278..405	CDD:270087
		C2_Dock-D	793..981	CDD:176079	44/206 (21%)
		DHR2_DOCK_D	1818..2231	CDD:212567	102/436 (23%)
Dock5	NP_001358941.1	SH3_DOCK1_5_A	12..67	CDD:212984
		DOCK_N	75..434	CDD:465040	48/262 (18%)
		C2	442..637	CDD:472691	44/230 (19%)
		DHR2_DOCK5	1238..1637	CDD:212581	102/436 (23%)