|
Fly 19 RENVSQLVRESAVLNKPLVVEPIDFEAFIAKNKTVIQNDPQRELLIYPTDDVSEIIMPRKQRTNA 83
:|:...|: |:.|.||.::||:|:|..|.:.||.|.||..||:|::|.||....|:.|:.|
Human 43 KEDSELLI--SSWLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGR--- 102
Fly 84 KSVADRFDPPNEAIVCPLHGPSMITNGNGHSQVSRQGSIQSNGSHHNGNGNGHTSSSSSSSLNNS 148
.:|
Human 103 -------------YIC------------------------------------------------- 105
Fly 149 NGHGQLSRKSSQCSNGSSSQKDSSYESALSSITLRSNLAQPEEVDEFADDGNAEDLVDGQPHGSR 213
|:: |.:.:| .|:.|
Human 106 -----------------------------STV--------PAKAEE-----EAQSL--------- 119
Fly 214 AECTRFTRQALYTYRAKNHLIHYKYNAYGGNCHDLPS-ISPAEELVEEIYEIDADQDRIDEQMTR 277
|..:.:.||.:..||::|||..|.|....||: :...::|...:||:|.:.|: ||....
Human 120 -----FVTECIKTYNSDWHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVDEEVDK-DEDAAS 178
Fly 278 --SQADTITKQGYLLKGPDSASDRMFANIGNKSFKRRYCYLRQEIDGTYILELHKDEK-QGEAKA 339
||...|||.|:|.||..::: .::..:|||||:.:|.|..||:|.|..:|||| ..|.|.
Human 179 LGSQKGGITKHGWLYKGNMNSA----ISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKG 239
Fly 340 TIVMDFCTDVVQNPKRGRFCFELRMTTGHKSFTLAAENEQDFKDWLSKISSVLAQN--RAQEEKR 402
:|.:|.|..||||.|..||.|||:| ....|:.|||::|.:.::|::.::.:|..| .|.:|||
Human 240 SIFLDSCMGVVQNNKVRRFAFELKM-QDKSSYLLAADSEVEMEEWITILNKILQLNFEAAMQEKR 303
Fly 403 NASLERHPSIGSNPSPQLQPPAMDPPTFGTLKGLDQSLHPQLMKYGRETDHSIALARREQRRRLF 467
|.. |...:...:|: |:..|||..| |:|.|..||.:..: :.|.|.:||
Human 304 NGD-----SHEDDEQSKLE---------GSGSGLDSYL-PELAKSAREAEIKL---KSESRVKLF 350
Fly 468 ACYQSPVK-----GSGSDNVEQYREHFGTRLLLTCHNLRFRLQ-CIPQDESSAGGVEQQVEPYIT 526
|..|.. .|....|:.:.|.||.|:|:.|::|.|.|| |:.::|. |....|||:..
Human 351 --YLDPDAQKLDFSSAEPEVKSFEEKFGKRILVKCNDLSFNLQCCVAENEE---GPTTNVEPFFV 410
Fly 527 SLALFDAKANRKLSENFYFNVNEQWAAQLLPNTPVPSSVAGCGVPRKSAEGDERSTACQAPHSLF 591
:|:|||.|.|||:|.:|:.::|.....|:|..|. |:.:.|.| |:| |:.
Human 411 TLSLFDIKYNRKISADFHVDLNHFSVRQMLATTS-PALMNGSG---------------QSP-SVL 458
Fly 592 DGVSAELLRSNRQQFQQLRQCLLSVTAPHADIYLVVRIEKILQSGIAQVTEPYLKAGKDPKLGQK 656
.|:..| ...|..:|.:.|||.||.||:||.||||:||..|....|||:|:....|:.||
Human 459 KGILHE------AAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQK 517
Fly 657 VYKAAKSYAQHIGHYRQPFAWAARPLFKQYSHELDVDPKREFEFSPIYRQEIPKLKDEELLKLLV 721
|.|.||...|.:|.||.|||||||.|||..|..|| :...||.||||:..||.::::||||.
Human 518 VLKNAKQACQRLGQYRMPFAWAARTLFKDASGNLD----KNARFSAIYRQDSNKLSNDDMLKLLA 578
Fly 722 DYRKPEKLSKLTIIPGSLKMQMQFLDQTTPCGLSKSLAPLSTFSPSSKQSPTVEVAEFQSQSERD 786
|:|||||::||.:|.|:|.:.:..:....|..::.|..|...|...||...|.||.||.....:.
Human 579 DFRKPEKMAKLPVILGNLDITIDNVSSDFPNYVNSSYIPTKQFETCSKTPITFEVEEFVPCIPKH 643
Fly 787 AHPYTSFCNHLYVYPLSLQFDSQKLFSRARNITVVVELRDGDGEYSKPLKCIYGRPGQDLLVSQI 851
..|||.:.|||||||..|::||||.|::||||.:.:|.:|.|.|.|:||||||||||..:.....
Human 644 TQPYTIYTNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSA 708
Fly 852 ACPVLHHNVTPTWYEEIKLRLPLGLFPEHHLLFSFYHVSCNLS-----KKRDANAAFETPIGYAW 911
...||||:..|.:|:|||:.||..|..:||||.:|:||||:.| |||| ..||.:||:|
Human 709 FAAVLHHHQNPEFYDEIKIELPTQLHEKHHLLLTFFHVSCDNSSKGSTKKRD---VVETQVGYSW 770
Fly 912 LPLLQKNRICLEEQQLPVAATLPVGYLSIQPLGWGKGNCGPDIQWIDNQRNLYTVGLRLDSTVLT 976
||||:..|:...||.:||:|.||.|||..|.||.|: :.||:|:|:|..:.|..:...|.|||.|
Human 771 LPLLKDGRVVTSEQHIPVSANLPSGYLGYQELGMGR-HYGPEIKWVDGGKPLLKISTHLVSTVYT 834
Fly 977 ADQHLHNFFGHCERLLEGGKTGAVPAETETCKILKAAHAIDMKSLINYLPTVLNELFTLLVHTQS 1041
.||||||||.:|::. ::||.....|..|.||:.||::...:|.:|||:||:||.:|.....
Human 835 QDQHLHNFFQYCQKT----ESGAQALGNELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQ 895
Fly 1042 EEIGLNVIRLITNIIHLISDQAKRSDLLGAYVKYVFHA-PYYSQQTARQRTVHGELCRHLPYLLN 1105
||:.:||.|:|.:::....::...|. |.:||||.:.| ||.:.: .:|||.||.:.:..:|.
Human 896 EEVAVNVTRVIIHVVAQCHEEGLESH-LRSYVKYAYKAEPYVASE---YKTVHEELTKSMTTILK 956
Fly 1106 PSNPDFLIVNKFMRYSSIFFDLIIKSMAQHLLATGRIRMLRNERFPKEYGDRVEQLIKALMPYIT 1170
|| .|||..||.::||..|||::||||||||:...::::|||:|||..|...||.::..|||:||
Human 957 PS-ADFLTSNKLLKYSWFFFDVLIKSMAQHLIENSKVKLLRNQRFPASYHHAVETVVNMLMPHIT 1020
Fly 1171 TRFEDLSEETHLLNRSLAKFVRQCLSYMDRGFVFRLIRCYMGEFSPGNPRILHEYKFNFLQEICQ 1235
.:|.|..|.:...|.|||.|:::|.::|||||||:.|..|:..|:||:|:.|.||||.||:.:|.
Human 1021 QKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCN 1085
Fly 1236 HEHYVPLNL--PFVLNPKNRPPEMMQHFTLSEQFCRQHFLSGLLLQELKSSLNEVGHVRRHALGI 1298
||||:|||| ||......|..::...::|:::|||.|||.||||:|:.::|.|...||..|:.:
Human 1086 HEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISV 1150
Fly 1299 FKDLLAKHELDNRYQQKGQLSRIALLYVPWLGVVMDNIHRID--DLSESGACTPNGHVYADSASY 1361
.|:||.||..|:||..:...:|||.||:|..|::::|:.||: |:|. :..:|..
Human 1151 LKNLLIKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRDVSP----------FPVNAGM 1205
Fly 1362 TKRLSCSSSYVFSKDSSTFGSLTS-----TPRSKNRL--TMHCDQ-------ASPYRTSVHMKEH 1412
| .||.|. :|.: ||:..:.| ::|.|. ||||.||.
Human 1206 T-----------VKDESL--ALPAVNPLVTPQKGSTLDNSLHKDLLGAISGIASPYTTST----- 1252
Fly 1413 NYLAAIAGQPISNGISNLSLNS---NTDSGHSQDTTTIGAYTNGDTDVALRNGHNRSVSVTHAQI 1474
|..|.:.|..... :||||:|... .|.:...:| :.|.:|.::.::.:
Human 1253 ---------PNINSVRNADSRGSLISTDSGNSLPE------RNSEKSNSL-DKHQQSSTLGNSVV 1301
Fly 1475 LSRCDKFSSVESKDLLLGFLFIIKHLSQEQMIGWWQNCNESETLQFLSILDLCLLQFRYVGKKSV 1539
||||....|.|.||:.||:|:|.:|.:.:..:|...:.||.:.|.:|.::||.||:|:||:.:
Human 1302 --RCDKLDQSEIKSLLMCFLYILKSMSDDALFTYWNKASTSELMDFFTISEVCLHQFQYMGKRYI 1364
Fly 1540 VITTETRQGRLA---KANTLPARTQPPTGLENGSQEQQPS---SGTLNQTREHLLEDIDTLARNQ 1598
....| ..|.:. |:.|||. ::..||:.:...:|..| |.|.|.:..| .|.|.|.:
Human 1365 ARNQE-GLGPIVHDRKSQTLPV-SRNRTGMMHARLQQLGSLDNSLTFNHSYGH--SDADVLHQ-- 1423
Fly 1599 LALYESNLATEVGMIILDCLGLYVLQFR-QLLAD---SLVLPKVARVYLRFLQLGQSERLSKHVF 1659
:|.|:|:||||.:..||.|.|:.|.|: ||||| :.::.||..|||.|||..|||...|:||
Human 1424 -SLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSETALKNVF 1487
Fly 1660 AALRAFINNYAVALFKGNAMLCGQMVYELLKACDSRLVEIRHESCAVLYLLMRSNFEFSGRKALT 1724
.|||:.|..:....::|.|.:|..:.||:||.|:|:|..||.|:..:||.|||:||:::|:|:..
Human 1488 TALRSLIYKFPSTFYEGRADMCAALCYEILKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFV 1552
Fly 1725 RVHLQVIISVSQMIGNVIGLNNARFQESLSIINSYANSDKAMKGTGFPMEVKDLTRRVRTVLMAT 1789
|.||||||||||:|.:|:|:...|||:||||||:.||||:.:|.|.|..:|||||:|:|||||||
Human 1553 RTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMAT 1617
Fly 1790 AQMQAHHMDPERLLELQYSLANSYASTPELRHTWLVTMARNHEQNGNLSEAACCHLHIAALMCEY 1854
|||:.|..|||.|::||||||.|||||||||.|||.:|||.|.:||:|||||.|::|:.||:.||
Human 1618 AQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEY 1682
Fly 1855 L----------------------RLKGGCTLSWSSTAFGKISTNIPLDEQGLKLDAGAQDSQYTE 1897
| |.:|| ......|||..|:.||. :|..:..|.|.||..:.|
Human 1683 LTRKEAVQWEPPLLPHSHSACLRRSRGG-VFRQGCTAFRVITPNID-EEASMMEDVGMQDVHFNE 1745
Fly 1898 QMLLEQLKLCADFLDRAERFECLGELYKLILPMYERDRSYQDLAHCYEHLTQAYNKIVEVNRSGK 1962
.:|:|.|:.|||.|.:|||:|.:.::||||:|:||:.|.::.|||.|:.|.:||:|:.||..||:
Human 1746 DVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGR 1810
Fly 1963 RMLGRFYRVVFYGLM--------------YFEEDHAIEFVYKEPKLTSLSEISERLAKQYKEKFG 2013
|:||.::||.|:|.. :||::...|::|||||||.|||||:||.|.|.:|||
Human 1811 RLLGTYFRVAFFGQAAQYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFG 1875
Fly 2014 ADVVKMIMDSSPVKVDELDAKLAYIQVTHVIPFFSKDELDQRLNEFEQNHDVDTFMYETPFTKSG 2078
::.||||.||..|...:||:|.||||||||||||.:.||.:|..|||::|::..||:|.|||::|
Human 1876 SENVKMIQDSGKVNPKDLDSKYAYIQVTHVIPFFDEKELQERKTEFERSHNIRRFMFEMPFTQTG 1940
Fly 2079 AARGSVEEQWKRKTVIKTQYSFPYVLKRIPVKSREIIELSPIEVAIDEMQSKVSELEEII-LPPA 2142
..:|.||||.||:|::...:.||||.|||||..:...:|:|||||||||..||:||.::. ....
Human 1941 KRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEV 2005
Fly 2143 DVKKLQLRLQGSVAVTVNAGPLAYAHAFLDAKVVNNFSMDRVGDLKDVFRDFIVVCQKALFLNER 2207
|:.||||:|||||:|.|||||||||.||||......:..::|..||:|||.|:..|.:||.:|||
Human 2006 DMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNER 2070
Fly 2208 IISADQKEYHHVLKENYEKLCQALSELLDDESFQPLGDDADSINQRNSMALFNAISGASHNSRPY 2272
:|..||.||...:|.||.::.:.|||:: .|...||.:....: .||:.:||||||...::
Human 2071 LIKEDQLEYQEEMKANYREMAKELSEIM-HEQICPLEEKTSVL--PNSLHIFNAISGTPTST--- 2129
Fly 2273 FVDQNTSNST 2282
.|...||:|:
Human 2130 MVHGMTSSSS 2139
| 
