DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment santa-maria and SCARB1

DIOPT Version :9

Sequence 1:	NP_609121.2	Gene:	santa-maria / 34024	FlyBaseID:	FBgn0025697	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_001354910.1	Gene:	SCARB1 / 949	HGNCID:	1664	Length:	552	Species:	Homo sapiens

Alignment Length:	548	Identity:	155/548 - (28%)
Similarity:	261/548 - (47%)	Gaps:	49/548 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LGLFGILCGMFWV-------DLFDWIMHKEMALAPDTRVYENWKSPPIDLSLDIYLYNWTNPEDF 83
            ||:.|:||.:...       .|....:.|.:.:.|.:..:..||..||...|.:|.::..||.:.
Human    14 LGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEI 78

  Fly    84 GNLSTKPILEQVGPYRFIERPDKVDIHWHPENASVTYRRRSLFYFDAAGSNGSLDDEITTLNAVA 148
            .. ..||.:.:.|||.:.|...|.:|.:: .|.:|::.....|.|..:.|:||..|.|...|.:.
Human    79 LK-GEKPQVRERGPYVYREFRHKSNITFN-NNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILV 141

  Fly   149 LSAAATAKYWPPVKRSLVDVGLKMYGAEMSVQKSIDELLFTGYNDAMID-VAMAMP-IFGDEVKV 211
            |.||...:..|...:.::.:.....|....:.:::.|::: ||.|.::: :....| :|
Human   142 LGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMW-GYKDPLVNLINKYFPGMF------ 199

  Fly   212 PF-DKFGWFYTRNGSADLTGVFNVFTGADQLAKLGQMHSWNYQENTGFFDS-YCGMTNGSAGEFQ 274
            || ||||.|...|.|.  :|:|.||||...::::..:..||......|:.| .|.|.||::|:..
Human   200 PFKDKFGLFAELNNSD--SGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMW 262

  Fly   275 PQHLKPGDSVGLFTPDMCRTIPLDYVETVDIEGLEGYKFSGGPRSVDNGTQYPENLCFCGGQCVP 339
            |..:.|..|:..::|:.||::.|.|.|:...||:..|:|........||:.||.|..||  .|:.
Human   263 PPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFC--PCLE 325

  Fly   340 SGVMNISSCRFGSPVFMSYPHFFNADPYYPDQVEGLSPNQKDHEFYMVVQPSTGIPLEVAARFQV 404
            ||:.|:|:|||.:|:|:|:|||.||||...:.|.||.|||:.|..::.:.|.||||:..:.:.|:
Human   326 SGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQL 390

  Fly   405 NMLVEPIQGISLYTGIPRIFFPLVWFEQKVRITPD----MADQLKVLPIVMLSGHIFAGICLIVG 465
            ::.::.:.||.....|..:..||:||.:...:..:    ...||.::|.||   |....:.|.:|
Human   391 SLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVM---HYAQYVLLALG 452

  Fly   466 ITLLCWTPVQILLASCRNRRYDLRTKTKTNGQYKSRSQFSSAEELKSKASTLVCEKSVKGSPDSS 530
            ..||. .||     .|:     :|::... ||..:|:...|.......||......:...||..:
Human   453 CVLLL-VPV-----ICQ-----IRSQVGA-GQRAARADSHSLACWGKGASDRTLWPTAAWSPPPA 505

  Fly   531 PLLEKGRKPTIIKSQTGESVATASTAIS 558
            .:|.      :.:|.:|......||..|
Human   506 AVLR------LCRSGSGHCWGLRSTLAS 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
santa-maria	NP_609121.2	CD36	23..474	CDD:279474	137/462 (30%)
SCARB1	NP_001354910.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148205
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45589
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860