Protein Alignment santa-maria and Scarb2

DIOPT Version :10

• Sequence 1: NP_609121.2
• Gene: santa-maria / 34024
• FlyBaseID: FBgn0025697
• Length: 563
• Species: Drosophila melanogaster
• Sequence 2: NP_031670.1
• Gene: Scarb2 / 12492
• MGIID: 1196458
• Length: 478
• Species: Mus musculus
• Alignment Length: 436
• Identity: 130/436 - (29%)
• Similarity: 228/436 - (52%)
• Gaps: 35/436 - (8%)

  Fly    42 DWIMHKEMALAPDTRVYENWKSPPIDLSLDIYLYNWTNPEDF--GNLSTKPILEQVGPYRFIERP 104
            |..:.|.|.|...|:|:.:|:.||:.:.:..|.:|.||||:.  |.:   |:||:||||.:.|..
Mouse    34 DQTIEKNMVLQNGTKVFNSWEKPPLPVYIQFYFFNVTNPEEILQGEI---PLLEEVGPYTYRELR 95

  Fly   105 DKVDIHWHPENASVTYRRRSLFYFDAAGSNGSLD-DEITTLNAVALSAAATAKYWPPVKRSLVDV 168
            :|.:|.:.....:::......:.|:...|.|..: |.|.|:|...|:....|:.  .:.|.|::.
Mouse    96 NKANIQFGENGTTISAVTNKAYVFERNQSVGDPNVDLIRTINIPLLTVVDLAQL--TLLRELIEA 158

  Fly   169 GLKMYGAEMSVQKSIDELLFTGYNDAMIDVAMAMPIFGDEVKVPFDKFGWFYTRNGSADLTGVFN 233
            .||.|..::.|..::.|||: ||.|.::.:   :.||..:|.   ..||.||.|||:.|  |.:.
Mouse   159 MLKAYQQKLFVIHTVHELLW-GYKDEILSL---VHIFKPDVS---PNFGLFYERNGTND--GEYV 214

  Fly   234 VFTGADQLAKLGQMHSWNYQENTGFFDS-YCGMTNGSAGE-FQPQHLKPGDSVGLFTPDMCRTIP 296
            ..||.|......::..||.:.:..::.: .|.|.||:.|: |.|. :...:.:.||..|:||::.
Mouse   215 FLTGEDNYLNFSKIVEWNGKTSLDWWTTDTCNMINGTDGDSFHPL-ISKDEVLYLFPSDLCRSVH 278

  Fly   297 LDYVETVDIEGLEGYKFSGGPRSVDNGTQYPENLCFC--GGQCVPSGVMNISSCRFGSPVFMSYP 359
            :.:....::|||..:::......:.|.:   ||..||  .|.|:.|||:|||.|:.|:|:.||:|
Mouse   279 ITFSSFENVEGLPAFRYKVPAEILANTS---ENAGFCIPEGNCMDSGVLNISICKNGAPIIMSFP 340

  Fly   360 HFFNADPYYPDQVEGLSPNQKDHEFYMVVQPSTGIPLEVAARFQVNMLVEPIQGISLYTGIPRIF 424
            ||:.||..:...::|:.||:::||.::.:.|.|||.|..|.|||:|..|..:........|..:.
Mouse   341 HFYQADEKFVSAIKGMHPNKEEHESFVDINPLTGIILRGAKRFQINTYVRKLDDFVETGDIRTMV 405

  Fly   425 FPLVWFEQKVRITPDMADQLKV----------LPIVMLSGHIFAGI 460
            ||:::..:.|.|..:.|:|||.          :|.::::..:|.|:
Mouse   406 FPVMYLNESVLIDKETANQLKSVINTTLVVTNIPYIIMALGVFFGL 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
santa-maria	NP_609121.2	CD36	21..476	CDD:460076	130/436 (30%)
Scarb2	NP_031670.1	CD36	28..457	CDD:460076	130/436 (30%)
		Important for interaction with GBA1	155..191		11/39 (28%)