DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5973 and SEC14L5

DIOPT Version :9

Sequence 1:	NP_001162901.1	Gene:	CG5973 / 34023	FlyBaseID:	FBgn0031914	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_055507.1	Gene:	SEC14L5 / 9717	HGNCID:	29032	Length:	696	Species:	Homo sapiens

Alignment Length:	331	Identity:	71/331 - (21%)
Similarity:	138/331 - (41%)	Gaps:	54/331 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKA-ECISYDEHKL--PYID--LGSAQIRMEKEQAPEWALKKAQDELREVPGVKEQAIKELREL 60
            :|.| |.:|.|..||  .||:  ||                        .:..::|..:.:||..
Human   212 LGPALEAVSMDGDKLDADYIERCLG------------------------HLTPMQESCLIQLRHW 252

  Fly    61 IQNEKYLNLPLDDEYMMMFLRPTHYYPESALKRLKNFYHMKLKY--GAACENIIPSKLRNVFEAN 123
            :|......:| .||:::.|||...::.:.|.:.|:.....:.::  ....:...|..|...|.|.
Human   253 LQETHKGKIP-KDEHILRFLRAHDFHLDKAREMLRQSLSWRKQHQVDLLLQTWQPPALLEEFYAG 316

  Fly   124 ILNLLPQRDQHGRRLLVLEAGK---KWKPSQVPLVDLFRGI-------QLTVLGSMVEPYSQICG 178
            ..:   .:|..||.|.:|..|:   |.....|....|.|.:       |....||..:....|..
Human   317 GWH---YQDIDGRPLYILRLGQMDTKGLMKAVGEEALLRHVLSVNEEGQKRCEGSTRQLGRPISS 378

  Fly   179 SVVIIDMEGLPLSHITQFTPSFAAML--LDYIQECICMRLKAVHIVNNSYIFNMLFAVFKPFIRE 241
            ...::|:|||.:.|:  :.|...|:|  ::.:::.....|..:.||....:|.:|:.:..|||.|
Human   379 WTCLLDLEGLNMRHL--WRPGVKALLRMIEVVEDNYPETLGRLLIVRAPRVFPVLWTLISPFINE 441

  Fly   242 KLRKR-IFFHGKDYK---SLISHIEAKALPPKYGGSATWELPHGKVLGEFFECYSKDYELADS-Y 301
            ..|:: :.:.|.:|:   .|:.:::.:.:|...||.:...:|.|.::.:......::.|..|. :
Human   442 NTRRKFLIYSGSNYQGPGGLVDYLDREVIPDFLGGESVCNVPEGGLVPKSLYMTEEEQEHTDQLW 506

  Fly   302 GYTEGY 307
            .::|.|
Human   507 QWSETY 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5973	NP_001162901.1	CRAL_TRIO_N	51..96	CDD:215024	12/44 (27%)
CG5973	NP_001162901.1	SEC14	116..272	CDD:238099	39/171 (23%)
SEC14L5	NP_055507.1	PRELI	17..173	CDD:309720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214		0/1 (0%)
		CRAL_TRIO_N	243..288	CDD:215024	12/45 (27%)
		SEC14	306..479	CDD:214706	42/177 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820