DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5973 and Clvs1

DIOPT Version :9

Sequence 1:	NP_001162901.1	Gene:	CG5973 / 34023	FlyBaseID:	FBgn0031914	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_001342112.1	Gene:	Clvs1 / 74438	MGIID:	1921688	Length:	354	Species:	Mus musculus

Alignment Length:	282	Identity:	80/282 - (28%)
Similarity:	136/282 - (48%)	Gaps:	28/282 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LKKAQDELREVPGVKEQAIKELRELIQNEKYLN-LPLDDEYMMMFLRPTHYYPESALKRLKNFYH 99
            ::||:.||.|.|.:..|.|:::|::|.....:. |..||.:::.|||...::...|.:.|..::.
Mouse    35 IEKARLELNENPDILHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQ 99

  Fly   100 MK------LKYGAACENIIPSKLRNVFEANILNLLPQRDQHGRRLLVLEAGKKWKPSQVPLVDLF 158
            .:      .|...|.:..|...|.:.|.    .:|..||.:||::|:|.|. .|..|:....|:.
Mouse   100 YRQLNLDMFKNFKADDPGIKRALIDGFP----GVLENRDHYGRKILLLFAA-NWDQSRNSFTDIL 159

  Fly   159 RGIQLTVLGSMVEPYSQICGSVVIIDMEGLPLSHITQFTPSFAAMLLDYIQECICMRLKAVHIVN 223
            |.|.|::...:.:|..||.|.::|||.........::.|||...:.::.:|:....|...||.||
Mouse   160 RAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVN 224

  Fly   224 NSYIFNMLFAVFKPFIREKLRKRIFFHGKDYKSLISHIEAKALPPKYGGS------ATWELPHGK 282
            ..:..:.|:.:.|||:::|.|||||.||.:..||...|..:.||.::||:      .||.   ..
Mouse   225 QPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWA---RT 286

  Fly   283 VLGEFFECYSKDYELADSYGYT 304
            :||       .||...:.|.:|
Mouse   287 LLG-------PDYSDENDYTHT 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5973	NP_001162901.1	CRAL_TRIO_N	51..96	CDD:215024	12/45 (27%)
CG5973	NP_001162901.1	SEC14	116..272	CDD:238099	49/155 (32%)
Clvs1	NP_001342112.1	CRAL_TRIO_N	51..97	CDD:215024	12/45 (27%)
		CRAL_TRIO	125..274	CDD:366224	49/153 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59833
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8767
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.830