DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5973 and CLVS1

DIOPT Version :9

Sequence 1:	NP_001162901.1	Gene:	CG5973 / 34023	FlyBaseID:	FBgn0031914	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_775790.1	Gene:	CLVS1 / 157807	HGNCID:	23139	Length:	354	Species:	Homo sapiens

Alignment Length:	287	Identity:	83/287 - (28%)
Similarity:	139/287 - (48%)	Gaps:	29/287 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 APEWALKKAQDELREVPGVKEQAIKELRELIQNEKYLN-LPLDDEYMMMFLRPTHYYPESALKRL 94
            :|| .::||:.||.|.|.|..|.|:::|::|.....:. |..||.:::.|||...::...|.:.|
Human    31 SPE-TIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLL 94

  Fly    95 KNFYHMK------LKYGAACENIIPSKLRNVFEANILNLLPQRDQHGRRLLVLEAGKKWKPSQVP 153
            ..::..:      .|...|.:..|...|.:.|.    .:|..||.:||::|:|.|. .|..|:..
Human    95 AQYFQYRQLNLDMFKNFKADDPGIKRALIDGFP----GVLENRDHYGRKILLLFAA-NWDQSRNS 154

  Fly   154 LVDLFRGIQLTVLGSMVEPYSQICGSVVIIDMEGLPLSHITQFTPSFAAMLLDYIQECICMRLKA 218
            ..|:.|.|.|::...:.:|..||.|.::|||.........::.|||...:.::.:|:....|...
Human   155 FTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGG 219

  Fly   219 VHIVNNSYIFNMLFAVFKPFIREKLRKRIFFHGKDYKSLISHIEAKALPPKYGGS------ATWE 277
            ||.||..:..:.|:.:.|||:::|.|||||.||.:..||...|..:.||.::||:      .||.
Human   220 VHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWA 284

  Fly   278 LPHGKVLGEFFECYSKDYELADSYGYT 304
               ..:||       .||...:.|.:|
Human   285 ---RTLLG-------PDYSDENDYTHT 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5973	NP_001162901.1	CRAL_TRIO_N	51..96	CDD:215024	12/45 (27%)
CG5973	NP_001162901.1	SEC14	116..272	CDD:238099	49/155 (32%)
CLVS1	NP_775790.1	CRAL_TRIO_N	51..97	CDD:215024	12/45 (27%)
		CRAL_TRIO	125..274	CDD:306996	49/153 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59833
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8539
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.830